Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial

Detalhes bibliográficos
Autor(a) principal: Silva, Wallace Andrino da
Data de Publicação: 2020
Outros Autores: Varela, Carlo Victor A., Pinheiro, Aline Macedo, Scherer, Paula Castro, Francisco, Rossana P.V., Torres, Marcelo Luis Abramides, Carmona, Maria José C., Bliacheriene, Fernando, Andrade, Lúcia C., Pelosi, Paolo, Malbouisson, Luiz Marcelo S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/173687
Resumo: OBJECTIVES: The aim of this study was to determine whether a restrictive compared to a liberal fluid therapy will increase postoperative acute kidney injury (AKI) in patients with severe preeclampsia. METHODS: A total of 46 patients (mean age, 32 years; standard deviation, 6.8 years) with severe preeclampsia were randomized to liberal (1500 ml of lactated Ringer’s, n=23) or restrictive (250 ml of lactated Ringer’s, n=23) intravenous fluid regimen during cesarean section. The primary outcome was the development of a postoperative renal dysfunction defined by AKI Network stage X1. Serum cystatin C and neutrophil gelatinaseassociated lipocalin (NGAL) were evaluated at postoperative days 1 and 2. ClinicalTrials.gov: NCT02214186. RESULTS: The rate of postoperative AKI was 43.5% in the liberal fluid group and 43.5% in the restrictive fluid group (p=1.0). Intraoperative urine output was higher in the liberal (116 ml/h, IQR 69-191) than in the restrictive fluid group (80 ml/h, IQR 37-110, po0.05). In both groups, serum cystatin C did not change from postoperative day 1 compared to the preoperative period and significantly decreased on postoperative day 2 compared to postoperative day 1 (po0.05). In the restrictive fluid group, NGAL levels increased on postoperative day 1 compared to the preoperative period (po0.05) and decreased on postoperative day 2 compared to postoperative day 1 (po0.05). CONCLUSION: Among patients with severe preeclampsia, a restrictive fluid regimen during cesarean section was not associated with increased postoperative AKI.
id USP-19_ac08ada10ffe0e7fda282b99794d8755
oai_identifier_str oai:revistas.usp.br:article/173687
network_acronym_str USP-19
network_name_str Clinics
repository_id_str
spelling Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical TrialPreeclampsiaAcute Kidney InjuryCesarean SectionFluid TherapyOBJECTIVES: The aim of this study was to determine whether a restrictive compared to a liberal fluid therapy will increase postoperative acute kidney injury (AKI) in patients with severe preeclampsia. METHODS: A total of 46 patients (mean age, 32 years; standard deviation, 6.8 years) with severe preeclampsia were randomized to liberal (1500 ml of lactated Ringer’s, n=23) or restrictive (250 ml of lactated Ringer’s, n=23) intravenous fluid regimen during cesarean section. The primary outcome was the development of a postoperative renal dysfunction defined by AKI Network stage X1. Serum cystatin C and neutrophil gelatinaseassociated lipocalin (NGAL) were evaluated at postoperative days 1 and 2. ClinicalTrials.gov: NCT02214186. RESULTS: The rate of postoperative AKI was 43.5% in the liberal fluid group and 43.5% in the restrictive fluid group (p=1.0). Intraoperative urine output was higher in the liberal (116 ml/h, IQR 69-191) than in the restrictive fluid group (80 ml/h, IQR 37-110, po0.05). In both groups, serum cystatin C did not change from postoperative day 1 compared to the preoperative period and significantly decreased on postoperative day 2 compared to postoperative day 1 (po0.05). In the restrictive fluid group, NGAL levels increased on postoperative day 1 compared to the preoperative period (po0.05) and decreased on postoperative day 2 compared to postoperative day 1 (po0.05). CONCLUSION: Among patients with severe preeclampsia, a restrictive fluid regimen during cesarean section was not associated with increased postoperative AKI.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/17368710.6061/clinics/2020/e1797Clinics; Vol. 75 (2020); e1797Clinics; v. 75 (2020); e1797Clinics; Vol. 75 (2020); e17971980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/173687/162768https://www.revistas.usp.br/clinics/article/view/173687/162769Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessSilva, Wallace Andrino daVarela, Carlo Victor A.Pinheiro, Aline MacedoScherer, Paula CastroFrancisco, Rossana P.V.Torres, Marcelo Luis AbramidesCarmona, Maria José C.Bliacheriene, FernandoAndrade, Lúcia C.Pelosi, PaoloMalbouisson, Luiz Marcelo S.2020-08-15T14:31:00Zoai:revistas.usp.br:article/173687Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-08-15T14:31Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
title Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
spellingShingle Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
Silva, Wallace Andrino da
Preeclampsia
Acute Kidney Injury
Cesarean Section
Fluid Therapy
title_short Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
title_full Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
title_fullStr Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
title_full_unstemmed Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
title_sort Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
author Silva, Wallace Andrino da
author_facet Silva, Wallace Andrino da
Varela, Carlo Victor A.
Pinheiro, Aline Macedo
Scherer, Paula Castro
Francisco, Rossana P.V.
Torres, Marcelo Luis Abramides
Carmona, Maria José C.
Bliacheriene, Fernando
Andrade, Lúcia C.
Pelosi, Paolo
Malbouisson, Luiz Marcelo S.
author_role author
author2 Varela, Carlo Victor A.
Pinheiro, Aline Macedo
Scherer, Paula Castro
Francisco, Rossana P.V.
Torres, Marcelo Luis Abramides
Carmona, Maria José C.
Bliacheriene, Fernando
Andrade, Lúcia C.
Pelosi, Paolo
Malbouisson, Luiz Marcelo S.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Wallace Andrino da
Varela, Carlo Victor A.
Pinheiro, Aline Macedo
Scherer, Paula Castro
Francisco, Rossana P.V.
Torres, Marcelo Luis Abramides
Carmona, Maria José C.
Bliacheriene, Fernando
Andrade, Lúcia C.
Pelosi, Paolo
Malbouisson, Luiz Marcelo S.
dc.subject.por.fl_str_mv Preeclampsia
Acute Kidney Injury
Cesarean Section
Fluid Therapy
topic Preeclampsia
Acute Kidney Injury
Cesarean Section
Fluid Therapy
description OBJECTIVES: The aim of this study was to determine whether a restrictive compared to a liberal fluid therapy will increase postoperative acute kidney injury (AKI) in patients with severe preeclampsia. METHODS: A total of 46 patients (mean age, 32 years; standard deviation, 6.8 years) with severe preeclampsia were randomized to liberal (1500 ml of lactated Ringer’s, n=23) or restrictive (250 ml of lactated Ringer’s, n=23) intravenous fluid regimen during cesarean section. The primary outcome was the development of a postoperative renal dysfunction defined by AKI Network stage X1. Serum cystatin C and neutrophil gelatinaseassociated lipocalin (NGAL) were evaluated at postoperative days 1 and 2. ClinicalTrials.gov: NCT02214186. RESULTS: The rate of postoperative AKI was 43.5% in the liberal fluid group and 43.5% in the restrictive fluid group (p=1.0). Intraoperative urine output was higher in the liberal (116 ml/h, IQR 69-191) than in the restrictive fluid group (80 ml/h, IQR 37-110, po0.05). In both groups, serum cystatin C did not change from postoperative day 1 compared to the preoperative period and significantly decreased on postoperative day 2 compared to postoperative day 1 (po0.05). In the restrictive fluid group, NGAL levels increased on postoperative day 1 compared to the preoperative period (po0.05) and decreased on postoperative day 2 compared to postoperative day 1 (po0.05). CONCLUSION: Among patients with severe preeclampsia, a restrictive fluid regimen during cesarean section was not associated with increased postoperative AKI.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/173687
10.6061/clinics/2020/e1797
url https://www.revistas.usp.br/clinics/article/view/173687
identifier_str_mv 10.6061/clinics/2020/e1797
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/173687/162768
https://www.revistas.usp.br/clinics/article/view/173687/162769
dc.rights.driver.fl_str_mv Copyright (c) 2020 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/xml
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 75 (2020); e1797
Clinics; v. 75 (2020); e1797
Clinics; Vol. 75 (2020); e1797
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
_version_ 1800222765187334144