Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/173687 |
Resumo: | OBJECTIVES: The aim of this study was to determine whether a restrictive compared to a liberal fluid therapy will increase postoperative acute kidney injury (AKI) in patients with severe preeclampsia. METHODS: A total of 46 patients (mean age, 32 years; standard deviation, 6.8 years) with severe preeclampsia were randomized to liberal (1500 ml of lactated Ringer’s, n=23) or restrictive (250 ml of lactated Ringer’s, n=23) intravenous fluid regimen during cesarean section. The primary outcome was the development of a postoperative renal dysfunction defined by AKI Network stage X1. Serum cystatin C and neutrophil gelatinaseassociated lipocalin (NGAL) were evaluated at postoperative days 1 and 2. ClinicalTrials.gov: NCT02214186. RESULTS: The rate of postoperative AKI was 43.5% in the liberal fluid group and 43.5% in the restrictive fluid group (p=1.0). Intraoperative urine output was higher in the liberal (116 ml/h, IQR 69-191) than in the restrictive fluid group (80 ml/h, IQR 37-110, po0.05). In both groups, serum cystatin C did not change from postoperative day 1 compared to the preoperative period and significantly decreased on postoperative day 2 compared to postoperative day 1 (po0.05). In the restrictive fluid group, NGAL levels increased on postoperative day 1 compared to the preoperative period (po0.05) and decreased on postoperative day 2 compared to postoperative day 1 (po0.05). CONCLUSION: Among patients with severe preeclampsia, a restrictive fluid regimen during cesarean section was not associated with increased postoperative AKI. |
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Clinics |
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Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical TrialPreeclampsiaAcute Kidney InjuryCesarean SectionFluid TherapyOBJECTIVES: The aim of this study was to determine whether a restrictive compared to a liberal fluid therapy will increase postoperative acute kidney injury (AKI) in patients with severe preeclampsia. METHODS: A total of 46 patients (mean age, 32 years; standard deviation, 6.8 years) with severe preeclampsia were randomized to liberal (1500 ml of lactated Ringer’s, n=23) or restrictive (250 ml of lactated Ringer’s, n=23) intravenous fluid regimen during cesarean section. The primary outcome was the development of a postoperative renal dysfunction defined by AKI Network stage X1. Serum cystatin C and neutrophil gelatinaseassociated lipocalin (NGAL) were evaluated at postoperative days 1 and 2. ClinicalTrials.gov: NCT02214186. RESULTS: The rate of postoperative AKI was 43.5% in the liberal fluid group and 43.5% in the restrictive fluid group (p=1.0). Intraoperative urine output was higher in the liberal (116 ml/h, IQR 69-191) than in the restrictive fluid group (80 ml/h, IQR 37-110, po0.05). In both groups, serum cystatin C did not change from postoperative day 1 compared to the preoperative period and significantly decreased on postoperative day 2 compared to postoperative day 1 (po0.05). In the restrictive fluid group, NGAL levels increased on postoperative day 1 compared to the preoperative period (po0.05) and decreased on postoperative day 2 compared to postoperative day 1 (po0.05). CONCLUSION: Among patients with severe preeclampsia, a restrictive fluid regimen during cesarean section was not associated with increased postoperative AKI.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/17368710.6061/clinics/2020/e1797Clinics; Vol. 75 (2020); e1797Clinics; v. 75 (2020); e1797Clinics; Vol. 75 (2020); e17971980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/173687/162768https://www.revistas.usp.br/clinics/article/view/173687/162769Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessSilva, Wallace Andrino daVarela, Carlo Victor A.Pinheiro, Aline MacedoScherer, Paula CastroFrancisco, Rossana P.V.Torres, Marcelo Luis AbramidesCarmona, Maria José C.Bliacheriene, FernandoAndrade, Lúcia C.Pelosi, PaoloMalbouisson, Luiz Marcelo S.2020-08-15T14:31:00Zoai:revistas.usp.br:article/173687Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-08-15T14:31Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial |
title |
Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial |
spellingShingle |
Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial Silva, Wallace Andrino da Preeclampsia Acute Kidney Injury Cesarean Section Fluid Therapy |
title_short |
Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial |
title_full |
Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial |
title_fullStr |
Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial |
title_full_unstemmed |
Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial |
title_sort |
Restrictive versus Liberal Fluid Therapy for PostCesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial |
author |
Silva, Wallace Andrino da |
author_facet |
Silva, Wallace Andrino da Varela, Carlo Victor A. Pinheiro, Aline Macedo Scherer, Paula Castro Francisco, Rossana P.V. Torres, Marcelo Luis Abramides Carmona, Maria José C. Bliacheriene, Fernando Andrade, Lúcia C. Pelosi, Paolo Malbouisson, Luiz Marcelo S. |
author_role |
author |
author2 |
Varela, Carlo Victor A. Pinheiro, Aline Macedo Scherer, Paula Castro Francisco, Rossana P.V. Torres, Marcelo Luis Abramides Carmona, Maria José C. Bliacheriene, Fernando Andrade, Lúcia C. Pelosi, Paolo Malbouisson, Luiz Marcelo S. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Wallace Andrino da Varela, Carlo Victor A. Pinheiro, Aline Macedo Scherer, Paula Castro Francisco, Rossana P.V. Torres, Marcelo Luis Abramides Carmona, Maria José C. Bliacheriene, Fernando Andrade, Lúcia C. Pelosi, Paolo Malbouisson, Luiz Marcelo S. |
dc.subject.por.fl_str_mv |
Preeclampsia Acute Kidney Injury Cesarean Section Fluid Therapy |
topic |
Preeclampsia Acute Kidney Injury Cesarean Section Fluid Therapy |
description |
OBJECTIVES: The aim of this study was to determine whether a restrictive compared to a liberal fluid therapy will increase postoperative acute kidney injury (AKI) in patients with severe preeclampsia. METHODS: A total of 46 patients (mean age, 32 years; standard deviation, 6.8 years) with severe preeclampsia were randomized to liberal (1500 ml of lactated Ringer’s, n=23) or restrictive (250 ml of lactated Ringer’s, n=23) intravenous fluid regimen during cesarean section. The primary outcome was the development of a postoperative renal dysfunction defined by AKI Network stage X1. Serum cystatin C and neutrophil gelatinaseassociated lipocalin (NGAL) were evaluated at postoperative days 1 and 2. ClinicalTrials.gov: NCT02214186. RESULTS: The rate of postoperative AKI was 43.5% in the liberal fluid group and 43.5% in the restrictive fluid group (p=1.0). Intraoperative urine output was higher in the liberal (116 ml/h, IQR 69-191) than in the restrictive fluid group (80 ml/h, IQR 37-110, po0.05). In both groups, serum cystatin C did not change from postoperative day 1 compared to the preoperative period and significantly decreased on postoperative day 2 compared to postoperative day 1 (po0.05). In the restrictive fluid group, NGAL levels increased on postoperative day 1 compared to the preoperative period (po0.05) and decreased on postoperative day 2 compared to postoperative day 1 (po0.05). CONCLUSION: Among patients with severe preeclampsia, a restrictive fluid regimen during cesarean section was not associated with increased postoperative AKI. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/173687 10.6061/clinics/2020/e1797 |
url |
https://www.revistas.usp.br/clinics/article/view/173687 |
identifier_str_mv |
10.6061/clinics/2020/e1797 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/173687/162768 https://www.revistas.usp.br/clinics/article/view/173687/162769 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 75 (2020); e1797 Clinics; v. 75 (2020); e1797 Clinics; Vol. 75 (2020); e1797 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222765187334144 |