Aqueous two-phase systems: Towards novel and more disruptive applications

Detalhes bibliográficos
Autor(a) principal: Pereira, Jorge F.B. [UNESP]
Data de Publicação: 2020
Outros Autores: Freire, Mara G., Coutinho, João A.P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.fluid.2019.112341
http://hdl.handle.net/11449/198063
Resumo: Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products.
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spelling Aqueous two-phase systems: Towards novel and more disruptive applicationsAqueous biphasic systemsAqueous two-phase systemsBioanalyticsBiomaterialsBioprintingBiotechnologyMicropatterningPurificationSeparationAqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Centro de Investigação em Materiais Cerâmicos e CompósitosFundação para a Ciência e a TecnologiaConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)European Regional Development FundMinistério da Ciência, Tecnologia e Ensino SuperiorDepartment of Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú/01, Campos VilleCICECO-Aveiro Institute of Materials Department of Chemistry University of AveiroDepartment of Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú/01, Campos VilleCAPES: 001Centro de Investigação em Materiais Cerâmicos e Compósitos: POCI-01-0145-FEDER-007679Fundação para a Ciência e a Tecnologia: POCI-01-0145-FEDER-030840Centro de Investigação em Materiais Cerâmicos e Compósitos: UID/CTM/50011/2019Universidade Estadual Paulista (Unesp)University of AveiroPereira, Jorge F.B. [UNESP]Freire, Mara G.Coutinho, João A.P.2020-12-12T00:58:00Z2020-12-12T00:58:00Z2020-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.fluid.2019.112341Fluid Phase Equilibria, v. 505.0378-3812http://hdl.handle.net/11449/19806310.1016/j.fluid.2019.1123412-s2.0-85074196376Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFluid Phase Equilibriainfo:eu-repo/semantics/openAccess2021-10-23T08:18:10Zoai:repositorio.unesp.br:11449/198063Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:54:58.282916Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Aqueous two-phase systems: Towards novel and more disruptive applications
title Aqueous two-phase systems: Towards novel and more disruptive applications
spellingShingle Aqueous two-phase systems: Towards novel and more disruptive applications
Pereira, Jorge F.B. [UNESP]
Aqueous biphasic systems
Aqueous two-phase systems
Bioanalytics
Biomaterials
Bioprinting
Biotechnology
Micropatterning
Purification
Separation
title_short Aqueous two-phase systems: Towards novel and more disruptive applications
title_full Aqueous two-phase systems: Towards novel and more disruptive applications
title_fullStr Aqueous two-phase systems: Towards novel and more disruptive applications
title_full_unstemmed Aqueous two-phase systems: Towards novel and more disruptive applications
title_sort Aqueous two-phase systems: Towards novel and more disruptive applications
author Pereira, Jorge F.B. [UNESP]
author_facet Pereira, Jorge F.B. [UNESP]
Freire, Mara G.
Coutinho, João A.P.
author_role author
author2 Freire, Mara G.
Coutinho, João A.P.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
University of Aveiro
dc.contributor.author.fl_str_mv Pereira, Jorge F.B. [UNESP]
Freire, Mara G.
Coutinho, João A.P.
dc.subject.por.fl_str_mv Aqueous biphasic systems
Aqueous two-phase systems
Bioanalytics
Biomaterials
Bioprinting
Biotechnology
Micropatterning
Purification
Separation
topic Aqueous biphasic systems
Aqueous two-phase systems
Bioanalytics
Biomaterials
Bioprinting
Biotechnology
Micropatterning
Purification
Separation
description Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T00:58:00Z
2020-12-12T00:58:00Z
2020-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.fluid.2019.112341
Fluid Phase Equilibria, v. 505.
0378-3812
http://hdl.handle.net/11449/198063
10.1016/j.fluid.2019.112341
2-s2.0-85074196376
url http://dx.doi.org/10.1016/j.fluid.2019.112341
http://hdl.handle.net/11449/198063
identifier_str_mv Fluid Phase Equilibria, v. 505.
0378-3812
10.1016/j.fluid.2019.112341
2-s2.0-85074196376
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fluid Phase Equilibria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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