Aqueous two-phase systems: Towards novel and more disruptive applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.fluid.2019.112341 http://hdl.handle.net/11449/198063 |
Resumo: | Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products. |
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Aqueous two-phase systems: Towards novel and more disruptive applicationsAqueous biphasic systemsAqueous two-phase systemsBioanalyticsBiomaterialsBioprintingBiotechnologyMicropatterningPurificationSeparationAqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Centro de Investigação em Materiais Cerâmicos e CompósitosFundação para a Ciência e a TecnologiaConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)European Regional Development FundMinistério da Ciência, Tecnologia e Ensino SuperiorDepartment of Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú/01, Campos VilleCICECO-Aveiro Institute of Materials Department of Chemistry University of AveiroDepartment of Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú/01, Campos VilleCAPES: 001Centro de Investigação em Materiais Cerâmicos e Compósitos: POCI-01-0145-FEDER-007679Fundação para a Ciência e a Tecnologia: POCI-01-0145-FEDER-030840Centro de Investigação em Materiais Cerâmicos e Compósitos: UID/CTM/50011/2019Universidade Estadual Paulista (Unesp)University of AveiroPereira, Jorge F.B. [UNESP]Freire, Mara G.Coutinho, João A.P.2020-12-12T00:58:00Z2020-12-12T00:58:00Z2020-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.fluid.2019.112341Fluid Phase Equilibria, v. 505.0378-3812http://hdl.handle.net/11449/19806310.1016/j.fluid.2019.1123412-s2.0-85074196376Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFluid Phase Equilibriainfo:eu-repo/semantics/openAccess2021-10-23T08:18:10Zoai:repositorio.unesp.br:11449/198063Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:54:58.282916Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title |
Aqueous two-phase systems: Towards novel and more disruptive applications |
spellingShingle |
Aqueous two-phase systems: Towards novel and more disruptive applications Pereira, Jorge F.B. [UNESP] Aqueous biphasic systems Aqueous two-phase systems Bioanalytics Biomaterials Bioprinting Biotechnology Micropatterning Purification Separation |
title_short |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title_full |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title_fullStr |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title_full_unstemmed |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title_sort |
Aqueous two-phase systems: Towards novel and more disruptive applications |
author |
Pereira, Jorge F.B. [UNESP] |
author_facet |
Pereira, Jorge F.B. [UNESP] Freire, Mara G. Coutinho, João A.P. |
author_role |
author |
author2 |
Freire, Mara G. Coutinho, João A.P. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Aveiro |
dc.contributor.author.fl_str_mv |
Pereira, Jorge F.B. [UNESP] Freire, Mara G. Coutinho, João A.P. |
dc.subject.por.fl_str_mv |
Aqueous biphasic systems Aqueous two-phase systems Bioanalytics Biomaterials Bioprinting Biotechnology Micropatterning Purification Separation |
topic |
Aqueous biphasic systems Aqueous two-phase systems Bioanalytics Biomaterials Bioprinting Biotechnology Micropatterning Purification Separation |
description |
Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T00:58:00Z 2020-12-12T00:58:00Z 2020-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.fluid.2019.112341 Fluid Phase Equilibria, v. 505. 0378-3812 http://hdl.handle.net/11449/198063 10.1016/j.fluid.2019.112341 2-s2.0-85074196376 |
url |
http://dx.doi.org/10.1016/j.fluid.2019.112341 http://hdl.handle.net/11449/198063 |
identifier_str_mv |
Fluid Phase Equilibria, v. 505. 0378-3812 10.1016/j.fluid.2019.112341 2-s2.0-85074196376 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fluid Phase Equilibria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129138557452288 |