Aqueous two-phase systems: Towards novel and more disruptive applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/28213 |
Resumo: | Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products. |
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Aqueous two-phase systems: Towards novel and more disruptive applicationsAqueous two-phase systemsAqueous biphasic systemsBiotechnologySeparationPurification; separationBioanalyticsBiomaterialsBioprintingMicropatterningAqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products.Elsevier2020-04-08T09:20:57Z2020-02-01T00:00:00Z2020-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/28213eng0378-381210.1016/j.fluid.2019.112341Pereira, Jorge F.B.Freire, Mara G.Coutinho, João A.P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:54:34Zoai:ria.ua.pt:10773/28213Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:48.407867Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title |
Aqueous two-phase systems: Towards novel and more disruptive applications |
spellingShingle |
Aqueous two-phase systems: Towards novel and more disruptive applications Pereira, Jorge F.B. Aqueous two-phase systems Aqueous biphasic systems Biotechnology Separation Purification; separation Bioanalytics Biomaterials Bioprinting Micropatterning |
title_short |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title_full |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title_fullStr |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title_full_unstemmed |
Aqueous two-phase systems: Towards novel and more disruptive applications |
title_sort |
Aqueous two-phase systems: Towards novel and more disruptive applications |
author |
Pereira, Jorge F.B. |
author_facet |
Pereira, Jorge F.B. Freire, Mara G. Coutinho, João A.P. |
author_role |
author |
author2 |
Freire, Mara G. Coutinho, João A.P. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Pereira, Jorge F.B. Freire, Mara G. Coutinho, João A.P. |
dc.subject.por.fl_str_mv |
Aqueous two-phase systems Aqueous biphasic systems Biotechnology Separation Purification; separation Bioanalytics Biomaterials Bioprinting Micropatterning |
topic |
Aqueous two-phase systems Aqueous biphasic systems Biotechnology Separation Purification; separation Bioanalytics Biomaterials Bioprinting Micropatterning |
description |
Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04-08T09:20:57Z 2020-02-01T00:00:00Z 2020-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/28213 |
url |
http://hdl.handle.net/10773/28213 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0378-3812 10.1016/j.fluid.2019.112341 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137663820759040 |