Aqueous two-phase systems: Towards novel and more disruptive applications

Detalhes bibliográficos
Autor(a) principal: Pereira, Jorge F.B.
Data de Publicação: 2020
Outros Autores: Freire, Mara G., Coutinho, João A.P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/28213
Resumo: Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products.
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spelling Aqueous two-phase systems: Towards novel and more disruptive applicationsAqueous two-phase systemsAqueous biphasic systemsBiotechnologySeparationPurification; separationBioanalyticsBiomaterialsBioprintingMicropatterningAqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products.Elsevier2020-04-08T09:20:57Z2020-02-01T00:00:00Z2020-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/28213eng0378-381210.1016/j.fluid.2019.112341Pereira, Jorge F.B.Freire, Mara G.Coutinho, João A.P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:54:34Zoai:ria.ua.pt:10773/28213Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:48.407867Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Aqueous two-phase systems: Towards novel and more disruptive applications
title Aqueous two-phase systems: Towards novel and more disruptive applications
spellingShingle Aqueous two-phase systems: Towards novel and more disruptive applications
Pereira, Jorge F.B.
Aqueous two-phase systems
Aqueous biphasic systems
Biotechnology
Separation
Purification; separation
Bioanalytics
Biomaterials
Bioprinting
Micropatterning
title_short Aqueous two-phase systems: Towards novel and more disruptive applications
title_full Aqueous two-phase systems: Towards novel and more disruptive applications
title_fullStr Aqueous two-phase systems: Towards novel and more disruptive applications
title_full_unstemmed Aqueous two-phase systems: Towards novel and more disruptive applications
title_sort Aqueous two-phase systems: Towards novel and more disruptive applications
author Pereira, Jorge F.B.
author_facet Pereira, Jorge F.B.
Freire, Mara G.
Coutinho, João A.P.
author_role author
author2 Freire, Mara G.
Coutinho, João A.P.
author2_role author
author
dc.contributor.author.fl_str_mv Pereira, Jorge F.B.
Freire, Mara G.
Coutinho, João A.P.
dc.subject.por.fl_str_mv Aqueous two-phase systems
Aqueous biphasic systems
Biotechnology
Separation
Purification; separation
Bioanalytics
Biomaterials
Bioprinting
Micropatterning
topic Aqueous two-phase systems
Aqueous biphasic systems
Biotechnology
Separation
Purification; separation
Bioanalytics
Biomaterials
Bioprinting
Micropatterning
description Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-08T09:20:57Z
2020-02-01T00:00:00Z
2020-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/28213
url http://hdl.handle.net/10773/28213
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0378-3812
10.1016/j.fluid.2019.112341
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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