Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis

Detalhes bibliográficos
Autor(a) principal: Moriguchi, Sônia Marta [UNESP]
Data de Publicação: 2010
Outros Autores: De Luca, Laurival Antonio [UNESP], Griva, Beatriz Lotufo [UNESP], Koga, Katia Hiromoto [UNESP], Da Silva, Eduardo Tinois, Vespoli, Heloísa Maria de Luca [UNESP], Uemura, Gilberto [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3892/etm_00000033
http://hdl.handle.net/11449/11368
Resumo: Scintimammography using Tc-99m-sestamibi is a noninvasive and painless diagnostic imaging method that is used to detect breast cancer when mammography is inconclusive Because of the advantages of labeling v '7,ith Tc-99m-sestamibi and its high efficiency in detecting carcinomas, it is the most widespread agent for this purpose Its accumulation in the tumor has multifactorial causes and does not depend on the presence of architectural distortion or local or diffuse density variation in the breast The objective of tfiis study was to evaluate the accuracy of scintimammography 1 for detecting breast cancer One hundred and fifty-seven patients presenting 158 palpable and non-palpable breast nodules were evaluated Three patients were male and 154 were female, aged between 14 and 81 years All patients underwent scintimammography, and the nodule was subjected i to cytological or histological study, i e, the gold standard for diagnosing cancer One hundred and eleven malignant and 47 benign nodules were detected, with predominance of ductal carcinomas (n=94) and fibroadenoma/fibrocysiic condition (n=11/n=11), respectively The mean size was 3 11 cm (7-10 cm) among the malignant nodules and 2 07 cm among the benign nodules (0 5-10 cm) The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 89, 89, 95, 78 and 89%, respectively Analysis on the histological types showed that the technique was more effective on tumors that were more aggressive, such as ductal carcinoma In this study, Tc-99m-sestamibi scintim immography was shown to be an important tool for diagnosing breast cancer when mammography was inconclusive
id UNSP_8c6eb637998dcf286d1126edf1987814
oai_identifier_str oai:repositorio.unesp.br:11449/11368
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosisscintimammographybreast cancerTc-99m-sestamibiScintimammography using Tc-99m-sestamibi is a noninvasive and painless diagnostic imaging method that is used to detect breast cancer when mammography is inconclusive Because of the advantages of labeling v '7,ith Tc-99m-sestamibi and its high efficiency in detecting carcinomas, it is the most widespread agent for this purpose Its accumulation in the tumor has multifactorial causes and does not depend on the presence of architectural distortion or local or diffuse density variation in the breast The objective of tfiis study was to evaluate the accuracy of scintimammography 1 for detecting breast cancer One hundred and fifty-seven patients presenting 158 palpable and non-palpable breast nodules were evaluated Three patients were male and 154 were female, aged between 14 and 81 years All patients underwent scintimammography, and the nodule was subjected i to cytological or histological study, i e, the gold standard for diagnosing cancer One hundred and eleven malignant and 47 benign nodules were detected, with predominance of ductal carcinomas (n=94) and fibroadenoma/fibrocysiic condition (n=11/n=11), respectively The mean size was 3 11 cm (7-10 cm) among the malignant nodules and 2 07 cm among the benign nodules (0 5-10 cm) The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 89, 89, 95, 78 and 89%, respectively Analysis on the histological types showed that the technique was more effective on tumors that were more aggressive, such as ductal carcinoma In this study, Tc-99m-sestamibi scintim immography was shown to be an important tool for diagnosing breast cancer when mammography was inconclusiveBarretos Canc Hosp, Dept Nucl Med, BR-14784400 São Paulo, BrazilSão Paulo State Univ UNESP, Dept Nucl Med, Botucatu Med Sch, BR-18618970 São Paulo, BrazilSão Paulo State Univ UNESP, Dept Obstet & Gynecol, Botucatu Med Sch, BR-18618970 São Paulo, BrazilSão Paulo State Univ UNESP, Dept Nucl Med, Botucatu Med Sch, BR-18618970 São Paulo, BrazilSão Paulo State Univ UNESP, Dept Obstet & Gynecol, Botucatu Med Sch, BR-18618970 São Paulo, BrazilSpandidos Publ LtdBarretos Canc HospUniversidade Estadual Paulista (Unesp)Moriguchi, Sônia Marta [UNESP]De Luca, Laurival Antonio [UNESP]Griva, Beatriz Lotufo [UNESP]Koga, Katia Hiromoto [UNESP]Da Silva, Eduardo TinoisVespoli, Heloísa Maria de Luca [UNESP]Uemura, Gilberto [UNESP]2014-05-20T13:33:15Z2014-05-20T13:33:15Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article205-209http://dx.doi.org/10.3892/etm_00000033Experimental and Therapeutic Medicine. Athens: Spandidos Publ Ltd, v. 1, n. 1, p. 205-209, 2010.1792-0981http://hdl.handle.net/11449/1136810.3892/etm_00000033WOS:00028456210003398786481435771248550647632202059Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental and Therapeutic Medicine1.4100,510info:eu-repo/semantics/openAccess2024-08-16T14:12:51Zoai:repositorio.unesp.br:11449/11368Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis
title Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis
spellingShingle Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis
Moriguchi, Sônia Marta [UNESP]
scintimammography
breast cancer
Tc-99m-sestamibi
title_short Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis
title_full Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis
title_fullStr Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis
title_full_unstemmed Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis
title_sort Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis
author Moriguchi, Sônia Marta [UNESP]
author_facet Moriguchi, Sônia Marta [UNESP]
De Luca, Laurival Antonio [UNESP]
Griva, Beatriz Lotufo [UNESP]
Koga, Katia Hiromoto [UNESP]
Da Silva, Eduardo Tinois
Vespoli, Heloísa Maria de Luca [UNESP]
Uemura, Gilberto [UNESP]
author_role author
author2 De Luca, Laurival Antonio [UNESP]
Griva, Beatriz Lotufo [UNESP]
Koga, Katia Hiromoto [UNESP]
Da Silva, Eduardo Tinois
Vespoli, Heloísa Maria de Luca [UNESP]
Uemura, Gilberto [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Barretos Canc Hosp
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Moriguchi, Sônia Marta [UNESP]
De Luca, Laurival Antonio [UNESP]
Griva, Beatriz Lotufo [UNESP]
Koga, Katia Hiromoto [UNESP]
Da Silva, Eduardo Tinois
Vespoli, Heloísa Maria de Luca [UNESP]
Uemura, Gilberto [UNESP]
dc.subject.por.fl_str_mv scintimammography
breast cancer
Tc-99m-sestamibi
topic scintimammography
breast cancer
Tc-99m-sestamibi
description Scintimammography using Tc-99m-sestamibi is a noninvasive and painless diagnostic imaging method that is used to detect breast cancer when mammography is inconclusive Because of the advantages of labeling v '7,ith Tc-99m-sestamibi and its high efficiency in detecting carcinomas, it is the most widespread agent for this purpose Its accumulation in the tumor has multifactorial causes and does not depend on the presence of architectural distortion or local or diffuse density variation in the breast The objective of tfiis study was to evaluate the accuracy of scintimammography 1 for detecting breast cancer One hundred and fifty-seven patients presenting 158 palpable and non-palpable breast nodules were evaluated Three patients were male and 154 were female, aged between 14 and 81 years All patients underwent scintimammography, and the nodule was subjected i to cytological or histological study, i e, the gold standard for diagnosing cancer One hundred and eleven malignant and 47 benign nodules were detected, with predominance of ductal carcinomas (n=94) and fibroadenoma/fibrocysiic condition (n=11/n=11), respectively The mean size was 3 11 cm (7-10 cm) among the malignant nodules and 2 07 cm among the benign nodules (0 5-10 cm) The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 89, 89, 95, 78 and 89%, respectively Analysis on the histological types showed that the technique was more effective on tumors that were more aggressive, such as ductal carcinoma In this study, Tc-99m-sestamibi scintim immography was shown to be an important tool for diagnosing breast cancer when mammography was inconclusive
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2014-05-20T13:33:15Z
2014-05-20T13:33:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3892/etm_00000033
Experimental and Therapeutic Medicine. Athens: Spandidos Publ Ltd, v. 1, n. 1, p. 205-209, 2010.
1792-0981
http://hdl.handle.net/11449/11368
10.3892/etm_00000033
WOS:000284562100033
9878648143577124
8550647632202059
url http://dx.doi.org/10.3892/etm_00000033
http://hdl.handle.net/11449/11368
identifier_str_mv Experimental and Therapeutic Medicine. Athens: Spandidos Publ Ltd, v. 1, n. 1, p. 205-209, 2010.
1792-0981
10.3892/etm_00000033
WOS:000284562100033
9878648143577124
8550647632202059
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Experimental and Therapeutic Medicine
1.410
0,510
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 205-209
dc.publisher.none.fl_str_mv Spandidos Publ Ltd
publisher.none.fl_str_mv Spandidos Publ Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128199921500160