Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jep.2022.116018 http://hdl.handle.net/11449/249515 |
Resumo: | Ethnopharmacological relevance: Serjania marginata Casar (Sapindaceae Family) Leaves are popularly used against abdominal pain. Antiulcer properties of S. marginata were scientifically described, however rare studies showed the antinociceptive effects of this plant. Aim of study: In this study, we investigated the antinociceptive and anti-inflammatory effects of aqueous extract obtained from Serjania marginata leaves (AESM) in nociception/inflammation models. Material and methods: AESM was analyzed in FIA-ESI-IT-MS and Mass spectrometer LTQ XL. AESM oral administration (p.o.) (30, 100 and 300 mg/kg), dexamethasone subcutaneous injection (1 mg/kg, s.c.) and morphine (5 mg/kg, s.c.) were tested against the acetic acid-induced nociception, carrageenan-induced acute inflammatory paw edema/hyperalgesia, formalin-induced nociception and carrageenan-induced pleurisy in Swiss mice. Results: Flavonoids rutin was detected in the phytochemical analysis of this extract. Oral treatment of AESM 300 mg/kg significantly reduced the number of acetic acid-induced abdominal writhing. AESM (100 and 300 mg/kg) significantly inhibited formalin-induced nociception, mechanical hyperalgesia and paw edema in carrageenan-model. Furthermore, AESM significantly inhibited leukocyte migration and protein exudation in the carrageenan-induced pleurisy test. Conclusion: This study confirms the antinociceptive, and anti-inflammatory activity of AESM, which may explain, in part, the popular use of this plant as a natural antinociceptive agent. This pharmacological action can be caused by flavonoids such as rutin and other compounds present in AESM. |
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Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leavescipó-timbóCipó-uvaInflammationRutinStomach painEthnopharmacological relevance: Serjania marginata Casar (Sapindaceae Family) Leaves are popularly used against abdominal pain. Antiulcer properties of S. marginata were scientifically described, however rare studies showed the antinociceptive effects of this plant. Aim of study: In this study, we investigated the antinociceptive and anti-inflammatory effects of aqueous extract obtained from Serjania marginata leaves (AESM) in nociception/inflammation models. Material and methods: AESM was analyzed in FIA-ESI-IT-MS and Mass spectrometer LTQ XL. AESM oral administration (p.o.) (30, 100 and 300 mg/kg), dexamethasone subcutaneous injection (1 mg/kg, s.c.) and morphine (5 mg/kg, s.c.) were tested against the acetic acid-induced nociception, carrageenan-induced acute inflammatory paw edema/hyperalgesia, formalin-induced nociception and carrageenan-induced pleurisy in Swiss mice. Results: Flavonoids rutin was detected in the phytochemical analysis of this extract. Oral treatment of AESM 300 mg/kg significantly reduced the number of acetic acid-induced abdominal writhing. AESM (100 and 300 mg/kg) significantly inhibited formalin-induced nociception, mechanical hyperalgesia and paw edema in carrageenan-model. Furthermore, AESM significantly inhibited leukocyte migration and protein exudation in the carrageenan-induced pleurisy test. Conclusion: This study confirms the antinociceptive, and anti-inflammatory activity of AESM, which may explain, in part, the popular use of this plant as a natural antinociceptive agent. This pharmacological action can be caused by flavonoids such as rutin and other compounds present in AESM.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do SulFederal University of Grande Dourados Faculty of Health Sciences, Mato Grosso do Sul StateSchool of Health Sciences Unigran Capital University Center, Mato Grosso do Sul StatePharmaceutical Sciences Food and Nutrition College Federal University of Mato Grosso Do Sul, Mato Grosso do Sul StateDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, São Paulo StateEnvironment and Regional Development Postgraduate Program Anhanguera-Uniderp University, Mato Grosso do Sul StateCenter of Studies in Natural Resources State University of Mato Grosso do Sul, Mato Grosso do Sul StateDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, São Paulo StateFaculty of Health SciencesUnigran Capital University CenterFederal University of Mato Grosso Do SulUniversidade Estadual Paulista (UNESP)Anhanguera-Uniderp UniversityState University of Mato Grosso do SulMatos Leitão, MaiconEuclides Silva-Filho, SauloArena, Arielle Cristina [UNESP]Heredia-Vieira, Silvia CristinaCardoso, Cláudia Andrea LimaKassuya, Cândida Aparecida Leite2023-07-29T16:01:48Z2023-07-29T16:01:48Z2023-03-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jep.2022.116018Journal of Ethnopharmacology, v. 304.1872-75730378-8741http://hdl.handle.net/11449/24951510.1016/j.jep.2022.1160182-s2.0-85144962627Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Ethnopharmacologyinfo:eu-repo/semantics/openAccess2023-07-29T16:01:49Zoai:repositorio.unesp.br:11449/249515Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T16:01:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves |
title |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves |
spellingShingle |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves Matos Leitão, Maicon cipó-timbó Cipó-uva Inflammation Rutin Stomach pain |
title_short |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves |
title_full |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves |
title_fullStr |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves |
title_full_unstemmed |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves |
title_sort |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves |
author |
Matos Leitão, Maicon |
author_facet |
Matos Leitão, Maicon Euclides Silva-Filho, Saulo Arena, Arielle Cristina [UNESP] Heredia-Vieira, Silvia Cristina Cardoso, Cláudia Andrea Lima Kassuya, Cândida Aparecida Leite |
author_role |
author |
author2 |
Euclides Silva-Filho, Saulo Arena, Arielle Cristina [UNESP] Heredia-Vieira, Silvia Cristina Cardoso, Cláudia Andrea Lima Kassuya, Cândida Aparecida Leite |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Faculty of Health Sciences Unigran Capital University Center Federal University of Mato Grosso Do Sul Universidade Estadual Paulista (UNESP) Anhanguera-Uniderp University State University of Mato Grosso do Sul |
dc.contributor.author.fl_str_mv |
Matos Leitão, Maicon Euclides Silva-Filho, Saulo Arena, Arielle Cristina [UNESP] Heredia-Vieira, Silvia Cristina Cardoso, Cláudia Andrea Lima Kassuya, Cândida Aparecida Leite |
dc.subject.por.fl_str_mv |
cipó-timbó Cipó-uva Inflammation Rutin Stomach pain |
topic |
cipó-timbó Cipó-uva Inflammation Rutin Stomach pain |
description |
Ethnopharmacological relevance: Serjania marginata Casar (Sapindaceae Family) Leaves are popularly used against abdominal pain. Antiulcer properties of S. marginata were scientifically described, however rare studies showed the antinociceptive effects of this plant. Aim of study: In this study, we investigated the antinociceptive and anti-inflammatory effects of aqueous extract obtained from Serjania marginata leaves (AESM) in nociception/inflammation models. Material and methods: AESM was analyzed in FIA-ESI-IT-MS and Mass spectrometer LTQ XL. AESM oral administration (p.o.) (30, 100 and 300 mg/kg), dexamethasone subcutaneous injection (1 mg/kg, s.c.) and morphine (5 mg/kg, s.c.) were tested against the acetic acid-induced nociception, carrageenan-induced acute inflammatory paw edema/hyperalgesia, formalin-induced nociception and carrageenan-induced pleurisy in Swiss mice. Results: Flavonoids rutin was detected in the phytochemical analysis of this extract. Oral treatment of AESM 300 mg/kg significantly reduced the number of acetic acid-induced abdominal writhing. AESM (100 and 300 mg/kg) significantly inhibited formalin-induced nociception, mechanical hyperalgesia and paw edema in carrageenan-model. Furthermore, AESM significantly inhibited leukocyte migration and protein exudation in the carrageenan-induced pleurisy test. Conclusion: This study confirms the antinociceptive, and anti-inflammatory activity of AESM, which may explain, in part, the popular use of this plant as a natural antinociceptive agent. This pharmacological action can be caused by flavonoids such as rutin and other compounds present in AESM. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T16:01:48Z 2023-07-29T16:01:48Z 2023-03-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jep.2022.116018 Journal of Ethnopharmacology, v. 304. 1872-7573 0378-8741 http://hdl.handle.net/11449/249515 10.1016/j.jep.2022.116018 2-s2.0-85144962627 |
url |
http://dx.doi.org/10.1016/j.jep.2022.116018 http://hdl.handle.net/11449/249515 |
identifier_str_mv |
Journal of Ethnopharmacology, v. 304. 1872-7573 0378-8741 10.1016/j.jep.2022.116018 2-s2.0-85144962627 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Ethnopharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797790156986515456 |