Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats

Detalhes bibliográficos
Autor(a) principal: de Morais Oliveira, Diego Augusto [UNESP]
Data de Publicação: 2021
Outros Autores: Lupi, Luiz Antonio [UNESP], Silveira, Henrique Spaulonci [UNESP], de Almeida Chuffa, Luiz Gustavo [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/iep.12388
http://hdl.handle.net/11449/206044
Resumo: In a large part of the population inefficient ingestion of proteins, whether for cultural, aesthetic or economic reasons, is a global concern. Low-protein diets can cause severe functional complications, mainly during the development and maturation of organs and systems, including the female reproductive system. The present study investigated the effect of nutritional protein restriction during puberty on the oestrous cycle and expression of sex steroid receptors (AR, ERα e ERβ) in ovarian and uterine tissues of adult rats. Protein restriction promoted lower body weight gain, feed efficiency and higher caloric intake. There was an increase in the oestrus phase arrest without changing the total length of the oestrous cycle. The consumption of low-protein diet also reduced the thickness of the uterine endometrium (uterine epithelium and endometrial stroma) in addition to increasing the number of primary and atretic follicles in the ovaries. Furthermore, the low-protein diet reduced the levels of androgen receptor (AR) and increased the oestrogen receptor β (ERβ) in the ovary, while no significant changes were observed in the uterus. Our study reinforces the importance of adequate protein intake during puberty, since physiological changes in this developmental period interfere with the histomorphometry of the ovaries and uteri, possibly resulting in impaired folliculogenesis and fertility in the reproductive period.
id UNSP_8cc6136c432463d973b2bd553c82de36
oai_identifier_str oai:repositorio.unesp.br:11449/206044
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in ratslow-protein dietnutritional parametersovaryprotein restrictionsex steroid receptorsuterusIn a large part of the population inefficient ingestion of proteins, whether for cultural, aesthetic or economic reasons, is a global concern. Low-protein diets can cause severe functional complications, mainly during the development and maturation of organs and systems, including the female reproductive system. The present study investigated the effect of nutritional protein restriction during puberty on the oestrous cycle and expression of sex steroid receptors (AR, ERα e ERβ) in ovarian and uterine tissues of adult rats. Protein restriction promoted lower body weight gain, feed efficiency and higher caloric intake. There was an increase in the oestrus phase arrest without changing the total length of the oestrous cycle. The consumption of low-protein diet also reduced the thickness of the uterine endometrium (uterine epithelium and endometrial stroma) in addition to increasing the number of primary and atretic follicles in the ovaries. Furthermore, the low-protein diet reduced the levels of androgen receptor (AR) and increased the oestrogen receptor β (ERβ) in the ovary, while no significant changes were observed in the uterus. Our study reinforces the importance of adequate protein intake during puberty, since physiological changes in this developmental period interfere with the histomorphometry of the ovaries and uteri, possibly resulting in impaired folliculogenesis and fertility in the reproductive period.Department of Structural and Functional Biology Institute of Biosciences UNESP - São Paulo State UniversityGraduate Program in Nutrition Institute of Biosciences of Botucatu UNESPDepartment of Structural and Functional Biology Institute of Biosciences UNESP - São Paulo State UniversityGraduate Program in Nutrition Institute of Biosciences of Botucatu UNESPUniversidade Estadual Paulista (Unesp)de Morais Oliveira, Diego Augusto [UNESP]Lupi, Luiz Antonio [UNESP]Silveira, Henrique Spaulonci [UNESP]de Almeida Chuffa, Luiz Gustavo [UNESP]2021-06-25T10:25:35Z2021-06-25T10:25:35Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article93-104http://dx.doi.org/10.1111/iep.12388International Journal of Experimental Pathology, v. 102, n. 2, p. 93-104, 2021.1365-26130959-9673http://hdl.handle.net/11449/20604410.1111/iep.123882-s2.0-85102554122Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Experimental Pathologyinfo:eu-repo/semantics/openAccess2021-10-22T20:42:51Zoai:repositorio.unesp.br:11449/206044Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:45:37.156255Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats
title Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats
spellingShingle Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats
de Morais Oliveira, Diego Augusto [UNESP]
low-protein diet
nutritional parameters
ovary
protein restriction
sex steroid receptors
uterus
title_short Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats
title_full Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats
title_fullStr Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats
title_full_unstemmed Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats
title_sort Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats
author de Morais Oliveira, Diego Augusto [UNESP]
author_facet de Morais Oliveira, Diego Augusto [UNESP]
Lupi, Luiz Antonio [UNESP]
Silveira, Henrique Spaulonci [UNESP]
de Almeida Chuffa, Luiz Gustavo [UNESP]
author_role author
author2 Lupi, Luiz Antonio [UNESP]
Silveira, Henrique Spaulonci [UNESP]
de Almeida Chuffa, Luiz Gustavo [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Morais Oliveira, Diego Augusto [UNESP]
Lupi, Luiz Antonio [UNESP]
Silveira, Henrique Spaulonci [UNESP]
de Almeida Chuffa, Luiz Gustavo [UNESP]
dc.subject.por.fl_str_mv low-protein diet
nutritional parameters
ovary
protein restriction
sex steroid receptors
uterus
topic low-protein diet
nutritional parameters
ovary
protein restriction
sex steroid receptors
uterus
description In a large part of the population inefficient ingestion of proteins, whether for cultural, aesthetic or economic reasons, is a global concern. Low-protein diets can cause severe functional complications, mainly during the development and maturation of organs and systems, including the female reproductive system. The present study investigated the effect of nutritional protein restriction during puberty on the oestrous cycle and expression of sex steroid receptors (AR, ERα e ERβ) in ovarian and uterine tissues of adult rats. Protein restriction promoted lower body weight gain, feed efficiency and higher caloric intake. There was an increase in the oestrus phase arrest without changing the total length of the oestrous cycle. The consumption of low-protein diet also reduced the thickness of the uterine endometrium (uterine epithelium and endometrial stroma) in addition to increasing the number of primary and atretic follicles in the ovaries. Furthermore, the low-protein diet reduced the levels of androgen receptor (AR) and increased the oestrogen receptor β (ERβ) in the ovary, while no significant changes were observed in the uterus. Our study reinforces the importance of adequate protein intake during puberty, since physiological changes in this developmental period interfere with the histomorphometry of the ovaries and uteri, possibly resulting in impaired folliculogenesis and fertility in the reproductive period.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:25:35Z
2021-06-25T10:25:35Z
2021-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/iep.12388
International Journal of Experimental Pathology, v. 102, n. 2, p. 93-104, 2021.
1365-2613
0959-9673
http://hdl.handle.net/11449/206044
10.1111/iep.12388
2-s2.0-85102554122
url http://dx.doi.org/10.1111/iep.12388
http://hdl.handle.net/11449/206044
identifier_str_mv International Journal of Experimental Pathology, v. 102, n. 2, p. 93-104, 2021.
1365-2613
0959-9673
10.1111/iep.12388
2-s2.0-85102554122
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Experimental Pathology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 93-104
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128974628323328