Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.7 http://hdl.handle.net/11449/16608 |
Resumo: | The biological response following subcutaneous and bone implantation of beta-wollastonite(beta-W)-doped alpha-tricalcium phosphate bioceramics in rats was evaluated. Tested materials were: tricalciurn phosphate (TCP), consisting of a mixture of alpha- and beta-polymorphs; TCP doped with 5 wt. % of beta-W (TCP5W), composed of alpha-TCP as only crystalline phase; and TCP doped with 15 wt. % of beta-W (TCP15), containing crystalline alpha-TCP and beta-W. Cylinders of 2x1 mm were implanted in tibiae and backs of adult male Rattus norvegicus, Holtzman rats. After 7, 30 and 120 days, animals were sacrificed and the tissue blocks containing the implants were excised, fixed and processed for histological examination. TCP, TCP5W and TCP15W implants were biocompatible but neither bioactive nor biodegradable in rat subcutaneous tissue. They were not osteoinductive in connective tissue either. However, in rat bone tissue beta-W-doped alpha-TCP implants (TCP5W and TCP15W) were bioactive, biodegradable and osteoconductive. The rates of biodegradation and new bone formation observed for TCP5W and TCP15W implants in rat bone tissue were greater than for non-doped TCP. |
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Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in RatsCalcium phosphatewollastonitein vivo testbiocompatibilityThe biological response following subcutaneous and bone implantation of beta-wollastonite(beta-W)-doped alpha-tricalcium phosphate bioceramics in rats was evaluated. Tested materials were: tricalciurn phosphate (TCP), consisting of a mixture of alpha- and beta-polymorphs; TCP doped with 5 wt. % of beta-W (TCP5W), composed of alpha-TCP as only crystalline phase; and TCP doped with 15 wt. % of beta-W (TCP15), containing crystalline alpha-TCP and beta-W. Cylinders of 2x1 mm were implanted in tibiae and backs of adult male Rattus norvegicus, Holtzman rats. After 7, 30 and 120 days, animals were sacrificed and the tissue blocks containing the implants were excised, fixed and processed for histological examination. TCP, TCP5W and TCP15W implants were biocompatible but neither bioactive nor biodegradable in rat subcutaneous tissue. They were not osteoinductive in connective tissue either. However, in rat bone tissue beta-W-doped alpha-TCP implants (TCP5W and TCP15W) were bioactive, biodegradable and osteoconductive. The rates of biodegradation and new bone formation observed for TCP5W and TCP15W implants in rat bone tissue were greater than for non-doped TCP.UNESP, Fac Odontol Araraquara, Depto Morfol, BR-14801903 Araraquara, SP, BrazilUNESP, Fac Odontol Araraquara, Depto Morfol, BR-14801903 Araraquara, SP, BrazilTrans Tech Publications LtdUniversidade Estadual Paulista (Unesp)Minarelli Gaspar, A. M. [UNESP]Saska, S. [UNESP]Carrodeguas, R. G.De Aza, A. H.Pena, P.De Aza, P. N.De Aza, S.2014-05-20T13:46:51Z2014-05-20T13:46:51Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjecthttp://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.7Bioceramics 21. Stafa-zurich: Trans Tech Publications Ltd, v. 396-398, p. 7-10, 2009.1013-9826http://hdl.handle.net/11449/1660810.4028/www.scientific.net/KEM.396-398.7WOS:0002653063000028379925533335630Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioceramics 210,180info:eu-repo/semantics/openAccess2024-09-27T15:15:20Zoai:repositorio.unesp.br:11449/16608Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-27T15:15:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats |
title |
Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats |
spellingShingle |
Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats Minarelli Gaspar, A. M. [UNESP] Calcium phosphate wollastonite in vivo test biocompatibility |
title_short |
Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats |
title_full |
Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats |
title_fullStr |
Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats |
title_full_unstemmed |
Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats |
title_sort |
Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats |
author |
Minarelli Gaspar, A. M. [UNESP] |
author_facet |
Minarelli Gaspar, A. M. [UNESP] Saska, S. [UNESP] Carrodeguas, R. G. De Aza, A. H. Pena, P. De Aza, P. N. De Aza, S. |
author_role |
author |
author2 |
Saska, S. [UNESP] Carrodeguas, R. G. De Aza, A. H. Pena, P. De Aza, P. N. De Aza, S. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Minarelli Gaspar, A. M. [UNESP] Saska, S. [UNESP] Carrodeguas, R. G. De Aza, A. H. Pena, P. De Aza, P. N. De Aza, S. |
dc.subject.por.fl_str_mv |
Calcium phosphate wollastonite in vivo test biocompatibility |
topic |
Calcium phosphate wollastonite in vivo test biocompatibility |
description |
The biological response following subcutaneous and bone implantation of beta-wollastonite(beta-W)-doped alpha-tricalcium phosphate bioceramics in rats was evaluated. Tested materials were: tricalciurn phosphate (TCP), consisting of a mixture of alpha- and beta-polymorphs; TCP doped with 5 wt. % of beta-W (TCP5W), composed of alpha-TCP as only crystalline phase; and TCP doped with 15 wt. % of beta-W (TCP15), containing crystalline alpha-TCP and beta-W. Cylinders of 2x1 mm were implanted in tibiae and backs of adult male Rattus norvegicus, Holtzman rats. After 7, 30 and 120 days, animals were sacrificed and the tissue blocks containing the implants were excised, fixed and processed for histological examination. TCP, TCP5W and TCP15W implants were biocompatible but neither bioactive nor biodegradable in rat subcutaneous tissue. They were not osteoinductive in connective tissue either. However, in rat bone tissue beta-W-doped alpha-TCP implants (TCP5W and TCP15W) were bioactive, biodegradable and osteoconductive. The rates of biodegradation and new bone formation observed for TCP5W and TCP15W implants in rat bone tissue were greater than for non-doped TCP. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2014-05-20T13:46:51Z 2014-05-20T13:46:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.7 Bioceramics 21. Stafa-zurich: Trans Tech Publications Ltd, v. 396-398, p. 7-10, 2009. 1013-9826 http://hdl.handle.net/11449/16608 10.4028/www.scientific.net/KEM.396-398.7 WOS:000265306300002 8379925533335630 |
url |
http://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.7 http://hdl.handle.net/11449/16608 |
identifier_str_mv |
Bioceramics 21. Stafa-zurich: Trans Tech Publications Ltd, v. 396-398, p. 7-10, 2009. 1013-9826 10.4028/www.scientific.net/KEM.396-398.7 WOS:000265306300002 8379925533335630 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bioceramics 21 0,180 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Trans Tech Publications Ltd |
publisher.none.fl_str_mv |
Trans Tech Publications Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546400803192832 |