Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats

Detalhes bibliográficos
Autor(a) principal: Minarelli Gaspar, A. M. [UNESP]
Data de Publicação: 2009
Outros Autores: Saska, S. [UNESP], Carrodeguas, R. G., De Aza, A. H., Pena, P., De Aza, P. N., De Aza, S.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.7
http://hdl.handle.net/11449/16608
Resumo: The biological response following subcutaneous and bone implantation of beta-wollastonite(beta-W)-doped alpha-tricalcium phosphate bioceramics in rats was evaluated. Tested materials were: tricalciurn phosphate (TCP), consisting of a mixture of alpha- and beta-polymorphs; TCP doped with 5 wt. % of beta-W (TCP5W), composed of alpha-TCP as only crystalline phase; and TCP doped with 15 wt. % of beta-W (TCP15), containing crystalline alpha-TCP and beta-W. Cylinders of 2x1 mm were implanted in tibiae and backs of adult male Rattus norvegicus, Holtzman rats. After 7, 30 and 120 days, animals were sacrificed and the tissue blocks containing the implants were excised, fixed and processed for histological examination. TCP, TCP5W and TCP15W implants were biocompatible but neither bioactive nor biodegradable in rat subcutaneous tissue. They were not osteoinductive in connective tissue either. However, in rat bone tissue beta-W-doped alpha-TCP implants (TCP5W and TCP15W) were bioactive, biodegradable and osteoconductive. The rates of biodegradation and new bone formation observed for TCP5W and TCP15W implants in rat bone tissue were greater than for non-doped TCP.
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spelling Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in RatsCalcium phosphatewollastonitein vivo testbiocompatibilityThe biological response following subcutaneous and bone implantation of beta-wollastonite(beta-W)-doped alpha-tricalcium phosphate bioceramics in rats was evaluated. Tested materials were: tricalciurn phosphate (TCP), consisting of a mixture of alpha- and beta-polymorphs; TCP doped with 5 wt. % of beta-W (TCP5W), composed of alpha-TCP as only crystalline phase; and TCP doped with 15 wt. % of beta-W (TCP15), containing crystalline alpha-TCP and beta-W. Cylinders of 2x1 mm were implanted in tibiae and backs of adult male Rattus norvegicus, Holtzman rats. After 7, 30 and 120 days, animals were sacrificed and the tissue blocks containing the implants were excised, fixed and processed for histological examination. TCP, TCP5W and TCP15W implants were biocompatible but neither bioactive nor biodegradable in rat subcutaneous tissue. They were not osteoinductive in connective tissue either. However, in rat bone tissue beta-W-doped alpha-TCP implants (TCP5W and TCP15W) were bioactive, biodegradable and osteoconductive. The rates of biodegradation and new bone formation observed for TCP5W and TCP15W implants in rat bone tissue were greater than for non-doped TCP.UNESP, Fac Odontol Araraquara, Depto Morfol, BR-14801903 Araraquara, SP, BrazilUNESP, Fac Odontol Araraquara, Depto Morfol, BR-14801903 Araraquara, SP, BrazilTrans Tech Publications LtdUniversidade Estadual Paulista (Unesp)Minarelli Gaspar, A. M. [UNESP]Saska, S. [UNESP]Carrodeguas, R. G.De Aza, A. H.Pena, P.De Aza, P. N.De Aza, S.2014-05-20T13:46:51Z2014-05-20T13:46:51Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjecthttp://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.7Bioceramics 21. Stafa-zurich: Trans Tech Publications Ltd, v. 396-398, p. 7-10, 2009.1013-9826http://hdl.handle.net/11449/1660810.4028/www.scientific.net/KEM.396-398.7WOS:0002653063000028379925533335630Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioceramics 210,180info:eu-repo/semantics/openAccess2024-09-27T15:15:20Zoai:repositorio.unesp.br:11449/16608Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-27T15:15:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
title Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
spellingShingle Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
Minarelli Gaspar, A. M. [UNESP]
Calcium phosphate
wollastonite
in vivo test
biocompatibility
title_short Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
title_full Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
title_fullStr Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
title_full_unstemmed Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
title_sort Biological Response to Wollastonite Doped alpha-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
author Minarelli Gaspar, A. M. [UNESP]
author_facet Minarelli Gaspar, A. M. [UNESP]
Saska, S. [UNESP]
Carrodeguas, R. G.
De Aza, A. H.
Pena, P.
De Aza, P. N.
De Aza, S.
author_role author
author2 Saska, S. [UNESP]
Carrodeguas, R. G.
De Aza, A. H.
Pena, P.
De Aza, P. N.
De Aza, S.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Minarelli Gaspar, A. M. [UNESP]
Saska, S. [UNESP]
Carrodeguas, R. G.
De Aza, A. H.
Pena, P.
De Aza, P. N.
De Aza, S.
dc.subject.por.fl_str_mv Calcium phosphate
wollastonite
in vivo test
biocompatibility
topic Calcium phosphate
wollastonite
in vivo test
biocompatibility
description The biological response following subcutaneous and bone implantation of beta-wollastonite(beta-W)-doped alpha-tricalcium phosphate bioceramics in rats was evaluated. Tested materials were: tricalciurn phosphate (TCP), consisting of a mixture of alpha- and beta-polymorphs; TCP doped with 5 wt. % of beta-W (TCP5W), composed of alpha-TCP as only crystalline phase; and TCP doped with 15 wt. % of beta-W (TCP15), containing crystalline alpha-TCP and beta-W. Cylinders of 2x1 mm were implanted in tibiae and backs of adult male Rattus norvegicus, Holtzman rats. After 7, 30 and 120 days, animals were sacrificed and the tissue blocks containing the implants were excised, fixed and processed for histological examination. TCP, TCP5W and TCP15W implants were biocompatible but neither bioactive nor biodegradable in rat subcutaneous tissue. They were not osteoinductive in connective tissue either. However, in rat bone tissue beta-W-doped alpha-TCP implants (TCP5W and TCP15W) were bioactive, biodegradable and osteoconductive. The rates of biodegradation and new bone formation observed for TCP5W and TCP15W implants in rat bone tissue were greater than for non-doped TCP.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
2014-05-20T13:46:51Z
2014-05-20T13:46:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.7
Bioceramics 21. Stafa-zurich: Trans Tech Publications Ltd, v. 396-398, p. 7-10, 2009.
1013-9826
http://hdl.handle.net/11449/16608
10.4028/www.scientific.net/KEM.396-398.7
WOS:000265306300002
8379925533335630
url http://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.7
http://hdl.handle.net/11449/16608
identifier_str_mv Bioceramics 21. Stafa-zurich: Trans Tech Publications Ltd, v. 396-398, p. 7-10, 2009.
1013-9826
10.4028/www.scientific.net/KEM.396-398.7
WOS:000265306300002
8379925533335630
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bioceramics 21
0,180
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Trans Tech Publications Ltd
publisher.none.fl_str_mv Trans Tech Publications Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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