Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/jcm8070954 http://hdl.handle.net/11449/184619 |
Resumo: | This animal study evaluated the osseointegration level of a new nanotextured titanium surface produced by anodization. Ti-cp micro-implants (1.5 mm diameter by 2.5 mm in length) divided into two groups: titanium nanotextured surface treatment (Test Group) and acid etched surface treatment (Control Group). Surface characterization included morphology analysis using scanning electron microscopy and wettability by measuring contact angle. Sixteen Wistar rats were submitted to two micro implants surgical placement procedures. In each rat, one type of micro implant placed in each tibia. The animals sacrificed after two (T1) and six weeks (T2) post-implantation. After the euthanasia, tibias processed for histomorphometric analysis, which allowed the evaluation of bone to implant contact (BIC) and the bone area fraction occupancy between the threads (BAFO). Our surface analysis data showed that the Control Group exhibited an irregular and non-homogenous topography while the Test Group showed a nanotextured surface. The Test Group showed higher wettability (contact angle = 5.1 +/- 0.7 degrees) than the Control Group (contact angle = 75.5 +/- 4.6 degrees). Concerning the histomorphometric analysis results for T1, Control and Test groups showed BIC percentages of 41.3 +/- 15.2% and 63.1 +/- 8.7% (p < 0.05), respectively, and for BAFO, 28.7 +/- 13.7% and 54.8 +/- 7.5%, respectively (p < 0.05). For T2, the histomorphometric analysis for Control and Test groups showed BIC percentages of 51.2 +/- 11.4% and 64.8 +/- 7.4% (p < 0.05), respectively and for BAFO, 36.4 +/- 10.3% and 57.9 +/- 9.3% (p < 0.05), respectively. The findings of the current study confirmed that the novel nanotextured surface exhibited superior wettability, improved peri-implant bone formation, and expedited osseointegration. |
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Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Ratsosseointegrationosteogenesistitaniumdental implantsThis animal study evaluated the osseointegration level of a new nanotextured titanium surface produced by anodization. Ti-cp micro-implants (1.5 mm diameter by 2.5 mm in length) divided into two groups: titanium nanotextured surface treatment (Test Group) and acid etched surface treatment (Control Group). Surface characterization included morphology analysis using scanning electron microscopy and wettability by measuring contact angle. Sixteen Wistar rats were submitted to two micro implants surgical placement procedures. In each rat, one type of micro implant placed in each tibia. The animals sacrificed after two (T1) and six weeks (T2) post-implantation. After the euthanasia, tibias processed for histomorphometric analysis, which allowed the evaluation of bone to implant contact (BIC) and the bone area fraction occupancy between the threads (BAFO). Our surface analysis data showed that the Control Group exhibited an irregular and non-homogenous topography while the Test Group showed a nanotextured surface. The Test Group showed higher wettability (contact angle = 5.1 +/- 0.7 degrees) than the Control Group (contact angle = 75.5 +/- 4.6 degrees). Concerning the histomorphometric analysis results for T1, Control and Test groups showed BIC percentages of 41.3 +/- 15.2% and 63.1 +/- 8.7% (p < 0.05), respectively, and for BAFO, 28.7 +/- 13.7% and 54.8 +/- 7.5%, respectively (p < 0.05). For T2, the histomorphometric analysis for Control and Test groups showed BIC percentages of 51.2 +/- 11.4% and 64.8 +/- 7.4% (p < 0.05), respectively and for BAFO, 36.4 +/- 10.3% and 57.9 +/- 9.3% (p < 0.05), respectively. The findings of the current study confirmed that the novel nanotextured surface exhibited superior wettability, improved peri-implant bone formation, and expedited osseointegration.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fac Sao Leopoldo Mandic, Dept Res, BR-13045755 Campinas, SP, BrazilUniv Calif Los Angeles, Dept Adv Prosthodont, Los Angeles, CA 90095 USASao Paulo State Univ, Sch Engn, Guaratingueta Campus, BR-516410 Sao Paulo, BrazilUniv Catolica San Antonio Murcia, Dept Oral & Implant Surg, Murcia 30107, SpainSao Paulo State Univ, Sch Engn, Guaratingueta Campus, BR-516410 Sao Paulo, BrazilCAPES: 001MdpiFac Sao Leopoldo MandicUniv Calif Los AngelesUniversidade Estadual Paulista (Unesp)Univ Catolica San Antonio MurciaPelegrine, Andre AntonioMoy, Peter KaryenMoshaverinia, AlirezaAmaral Escada, Ana Lucia do [UNESP]Calvo-Guirado, Jose LuisRosifini Alves Claro, Ana Paula [UNESP]2019-10-04T12:15:16Z2019-10-04T12:15:16Z2019-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12http://dx.doi.org/10.3390/jcm8070954Journal Of Clinical Medicine. Basel: Mdpi, v. 8, n. 7, 12 p., 2019.2077-0383http://hdl.handle.net/11449/18461910.3390/jcm8070954WOS:000479003300040Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Clinical Medicineinfo:eu-repo/semantics/openAccess2021-10-23T00:00:10Zoai:repositorio.unesp.br:11449/184619Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:02:48.143247Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats |
title |
Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats |
spellingShingle |
Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats Pelegrine, Andre Antonio osseointegration osteogenesis titanium dental implants |
title_short |
Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats |
title_full |
Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats |
title_fullStr |
Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats |
title_full_unstemmed |
Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats |
title_sort |
Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats |
author |
Pelegrine, Andre Antonio |
author_facet |
Pelegrine, Andre Antonio Moy, Peter Karyen Moshaverinia, Alireza Amaral Escada, Ana Lucia do [UNESP] Calvo-Guirado, Jose Luis Rosifini Alves Claro, Ana Paula [UNESP] |
author_role |
author |
author2 |
Moy, Peter Karyen Moshaverinia, Alireza Amaral Escada, Ana Lucia do [UNESP] Calvo-Guirado, Jose Luis Rosifini Alves Claro, Ana Paula [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Fac Sao Leopoldo Mandic Univ Calif Los Angeles Universidade Estadual Paulista (Unesp) Univ Catolica San Antonio Murcia |
dc.contributor.author.fl_str_mv |
Pelegrine, Andre Antonio Moy, Peter Karyen Moshaverinia, Alireza Amaral Escada, Ana Lucia do [UNESP] Calvo-Guirado, Jose Luis Rosifini Alves Claro, Ana Paula [UNESP] |
dc.subject.por.fl_str_mv |
osseointegration osteogenesis titanium dental implants |
topic |
osseointegration osteogenesis titanium dental implants |
description |
This animal study evaluated the osseointegration level of a new nanotextured titanium surface produced by anodization. Ti-cp micro-implants (1.5 mm diameter by 2.5 mm in length) divided into two groups: titanium nanotextured surface treatment (Test Group) and acid etched surface treatment (Control Group). Surface characterization included morphology analysis using scanning electron microscopy and wettability by measuring contact angle. Sixteen Wistar rats were submitted to two micro implants surgical placement procedures. In each rat, one type of micro implant placed in each tibia. The animals sacrificed after two (T1) and six weeks (T2) post-implantation. After the euthanasia, tibias processed for histomorphometric analysis, which allowed the evaluation of bone to implant contact (BIC) and the bone area fraction occupancy between the threads (BAFO). Our surface analysis data showed that the Control Group exhibited an irregular and non-homogenous topography while the Test Group showed a nanotextured surface. The Test Group showed higher wettability (contact angle = 5.1 +/- 0.7 degrees) than the Control Group (contact angle = 75.5 +/- 4.6 degrees). Concerning the histomorphometric analysis results for T1, Control and Test groups showed BIC percentages of 41.3 +/- 15.2% and 63.1 +/- 8.7% (p < 0.05), respectively, and for BAFO, 28.7 +/- 13.7% and 54.8 +/- 7.5%, respectively (p < 0.05). For T2, the histomorphometric analysis for Control and Test groups showed BIC percentages of 51.2 +/- 11.4% and 64.8 +/- 7.4% (p < 0.05), respectively and for BAFO, 36.4 +/- 10.3% and 57.9 +/- 9.3% (p < 0.05), respectively. The findings of the current study confirmed that the novel nanotextured surface exhibited superior wettability, improved peri-implant bone formation, and expedited osseointegration. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:15:16Z 2019-10-04T12:15:16Z 2019-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/jcm8070954 Journal Of Clinical Medicine. Basel: Mdpi, v. 8, n. 7, 12 p., 2019. 2077-0383 http://hdl.handle.net/11449/184619 10.3390/jcm8070954 WOS:000479003300040 |
url |
http://dx.doi.org/10.3390/jcm8070954 http://hdl.handle.net/11449/184619 |
identifier_str_mv |
Journal Of Clinical Medicine. Basel: Mdpi, v. 8, n. 7, 12 p., 2019. 2077-0383 10.3390/jcm8070954 WOS:000479003300040 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Clinical Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 |
dc.publisher.none.fl_str_mv |
Mdpi |
publisher.none.fl_str_mv |
Mdpi |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129387029069824 |