Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats

Detalhes bibliográficos
Autor(a) principal: Pelegrine, Andre Antonio
Data de Publicação: 2019
Outros Autores: Moy, Peter Karyen, Moshaverinia, Alireza, Amaral Escada, Ana Lucia do [UNESP], Calvo-Guirado, Jose Luis, Rosifini Alves Claro, Ana Paula [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/jcm8070954
http://hdl.handle.net/11449/184619
Resumo: This animal study evaluated the osseointegration level of a new nanotextured titanium surface produced by anodization. Ti-cp micro-implants (1.5 mm diameter by 2.5 mm in length) divided into two groups: titanium nanotextured surface treatment (Test Group) and acid etched surface treatment (Control Group). Surface characterization included morphology analysis using scanning electron microscopy and wettability by measuring contact angle. Sixteen Wistar rats were submitted to two micro implants surgical placement procedures. In each rat, one type of micro implant placed in each tibia. The animals sacrificed after two (T1) and six weeks (T2) post-implantation. After the euthanasia, tibias processed for histomorphometric analysis, which allowed the evaluation of bone to implant contact (BIC) and the bone area fraction occupancy between the threads (BAFO). Our surface analysis data showed that the Control Group exhibited an irregular and non-homogenous topography while the Test Group showed a nanotextured surface. The Test Group showed higher wettability (contact angle = 5.1 +/- 0.7 degrees) than the Control Group (contact angle = 75.5 +/- 4.6 degrees). Concerning the histomorphometric analysis results for T1, Control and Test groups showed BIC percentages of 41.3 +/- 15.2% and 63.1 +/- 8.7% (p < 0.05), respectively, and for BAFO, 28.7 +/- 13.7% and 54.8 +/- 7.5%, respectively (p < 0.05). For T2, the histomorphometric analysis for Control and Test groups showed BIC percentages of 51.2 +/- 11.4% and 64.8 +/- 7.4% (p < 0.05), respectively and for BAFO, 36.4 +/- 10.3% and 57.9 +/- 9.3% (p < 0.05), respectively. The findings of the current study confirmed that the novel nanotextured surface exhibited superior wettability, improved peri-implant bone formation, and expedited osseointegration.
id UNSP_8e9c4fdd20d2447e6e2a7b433b317f4b
oai_identifier_str oai:repositorio.unesp.br:11449/184619
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Ratsosseointegrationosteogenesistitaniumdental implantsThis animal study evaluated the osseointegration level of a new nanotextured titanium surface produced by anodization. Ti-cp micro-implants (1.5 mm diameter by 2.5 mm in length) divided into two groups: titanium nanotextured surface treatment (Test Group) and acid etched surface treatment (Control Group). Surface characterization included morphology analysis using scanning electron microscopy and wettability by measuring contact angle. Sixteen Wistar rats were submitted to two micro implants surgical placement procedures. In each rat, one type of micro implant placed in each tibia. The animals sacrificed after two (T1) and six weeks (T2) post-implantation. After the euthanasia, tibias processed for histomorphometric analysis, which allowed the evaluation of bone to implant contact (BIC) and the bone area fraction occupancy between the threads (BAFO). Our surface analysis data showed that the Control Group exhibited an irregular and non-homogenous topography while the Test Group showed a nanotextured surface. The Test Group showed higher wettability (contact angle = 5.1 +/- 0.7 degrees) than the Control Group (contact angle = 75.5 +/- 4.6 degrees). Concerning the histomorphometric analysis results for T1, Control and Test groups showed BIC percentages of 41.3 +/- 15.2% and 63.1 +/- 8.7% (p < 0.05), respectively, and for BAFO, 28.7 +/- 13.7% and 54.8 +/- 7.5%, respectively (p < 0.05). For T2, the histomorphometric analysis for Control and Test groups showed BIC percentages of 51.2 +/- 11.4% and 64.8 +/- 7.4% (p < 0.05), respectively and for BAFO, 36.4 +/- 10.3% and 57.9 +/- 9.3% (p < 0.05), respectively. The findings of the current study confirmed that the novel nanotextured surface exhibited superior wettability, improved peri-implant bone formation, and expedited osseointegration.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fac Sao Leopoldo Mandic, Dept Res, BR-13045755 Campinas, SP, BrazilUniv Calif Los Angeles, Dept Adv Prosthodont, Los Angeles, CA 90095 USASao Paulo State Univ, Sch Engn, Guaratingueta Campus, BR-516410 Sao Paulo, BrazilUniv Catolica San Antonio Murcia, Dept Oral & Implant Surg, Murcia 30107, SpainSao Paulo State Univ, Sch Engn, Guaratingueta Campus, BR-516410 Sao Paulo, BrazilCAPES: 001MdpiFac Sao Leopoldo MandicUniv Calif Los AngelesUniversidade Estadual Paulista (Unesp)Univ Catolica San Antonio MurciaPelegrine, Andre AntonioMoy, Peter KaryenMoshaverinia, AlirezaAmaral Escada, Ana Lucia do [UNESP]Calvo-Guirado, Jose LuisRosifini Alves Claro, Ana Paula [UNESP]2019-10-04T12:15:16Z2019-10-04T12:15:16Z2019-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12http://dx.doi.org/10.3390/jcm8070954Journal Of Clinical Medicine. Basel: Mdpi, v. 8, n. 7, 12 p., 2019.2077-0383http://hdl.handle.net/11449/18461910.3390/jcm8070954WOS:000479003300040Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Clinical Medicineinfo:eu-repo/semantics/openAccess2021-10-23T00:00:10Zoai:repositorio.unesp.br:11449/184619Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:02:48.143247Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
title Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
spellingShingle Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
Pelegrine, Andre Antonio
osseointegration
osteogenesis
titanium
dental implants
title_short Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
title_full Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
title_fullStr Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
title_full_unstemmed Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
title_sort Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats
author Pelegrine, Andre Antonio
author_facet Pelegrine, Andre Antonio
Moy, Peter Karyen
Moshaverinia, Alireza
Amaral Escada, Ana Lucia do [UNESP]
Calvo-Guirado, Jose Luis
Rosifini Alves Claro, Ana Paula [UNESP]
author_role author
author2 Moy, Peter Karyen
Moshaverinia, Alireza
Amaral Escada, Ana Lucia do [UNESP]
Calvo-Guirado, Jose Luis
Rosifini Alves Claro, Ana Paula [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Fac Sao Leopoldo Mandic
Univ Calif Los Angeles
Universidade Estadual Paulista (Unesp)
Univ Catolica San Antonio Murcia
dc.contributor.author.fl_str_mv Pelegrine, Andre Antonio
Moy, Peter Karyen
Moshaverinia, Alireza
Amaral Escada, Ana Lucia do [UNESP]
Calvo-Guirado, Jose Luis
Rosifini Alves Claro, Ana Paula [UNESP]
dc.subject.por.fl_str_mv osseointegration
osteogenesis
titanium
dental implants
topic osseointegration
osteogenesis
titanium
dental implants
description This animal study evaluated the osseointegration level of a new nanotextured titanium surface produced by anodization. Ti-cp micro-implants (1.5 mm diameter by 2.5 mm in length) divided into two groups: titanium nanotextured surface treatment (Test Group) and acid etched surface treatment (Control Group). Surface characterization included morphology analysis using scanning electron microscopy and wettability by measuring contact angle. Sixteen Wistar rats were submitted to two micro implants surgical placement procedures. In each rat, one type of micro implant placed in each tibia. The animals sacrificed after two (T1) and six weeks (T2) post-implantation. After the euthanasia, tibias processed for histomorphometric analysis, which allowed the evaluation of bone to implant contact (BIC) and the bone area fraction occupancy between the threads (BAFO). Our surface analysis data showed that the Control Group exhibited an irregular and non-homogenous topography while the Test Group showed a nanotextured surface. The Test Group showed higher wettability (contact angle = 5.1 +/- 0.7 degrees) than the Control Group (contact angle = 75.5 +/- 4.6 degrees). Concerning the histomorphometric analysis results for T1, Control and Test groups showed BIC percentages of 41.3 +/- 15.2% and 63.1 +/- 8.7% (p < 0.05), respectively, and for BAFO, 28.7 +/- 13.7% and 54.8 +/- 7.5%, respectively (p < 0.05). For T2, the histomorphometric analysis for Control and Test groups showed BIC percentages of 51.2 +/- 11.4% and 64.8 +/- 7.4% (p < 0.05), respectively and for BAFO, 36.4 +/- 10.3% and 57.9 +/- 9.3% (p < 0.05), respectively. The findings of the current study confirmed that the novel nanotextured surface exhibited superior wettability, improved peri-implant bone formation, and expedited osseointegration.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T12:15:16Z
2019-10-04T12:15:16Z
2019-07-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/jcm8070954
Journal Of Clinical Medicine. Basel: Mdpi, v. 8, n. 7, 12 p., 2019.
2077-0383
http://hdl.handle.net/11449/184619
10.3390/jcm8070954
WOS:000479003300040
url http://dx.doi.org/10.3390/jcm8070954
http://hdl.handle.net/11449/184619
identifier_str_mv Journal Of Clinical Medicine. Basel: Mdpi, v. 8, n. 7, 12 p., 2019.
2077-0383
10.3390/jcm8070954
WOS:000479003300040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Clinical Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
dc.publisher.none.fl_str_mv Mdpi
publisher.none.fl_str_mv Mdpi
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129387029069824