Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1292/jvms.20-0730 http://hdl.handle.net/11449/207799 |
Resumo: | This prospective, comparative, randomized, horizontal, and double-blind clinical study investigated the clinical efficacy of leucocyte-poor platelet-rich plasma (PRP, n=8) or allogeneic adipose-derived stem cells (ADSC, n=8) in dogs with bilateral degenerative hip joint disease (DHJD). Sixteen dogs were treated with two intra-articular injections of PRP or ADSCs, within a 30-day interval. The Canine Brief Pain Inventory (CBPI), the Helsinki Chronic Pain Index (HCPI), and Visual Analogue Scales for pain (VAS-pain) and locomotion (VAS-loc) were assessed by the dog owners. Analysis-of-gait using a force plate, response to palpation (VAS-palp), and the descriptive numerical scale for pain (DNS) were measured by a veterinarian. The assessments were performed before (baseline), 30 and 60 days after the first treatment. Data were analyzed using the unpaired t test, paired Wilcoxon test, Fisher’s exact test, and Mann-Whitney and Friedman tests (P<0.05). Compared with baseline HCPI, CBPI, VAS-pain, and VAS-palp scores reduced 41%, 52%, 51%, and 48% (P=0.0001–0.03) at 60 days in the ADSC group. In PRP-treated dogs, CBPI, VAS-loc, and DNS scores decreased by 43%, 43%, and 33% at 60 days, respectively (P=0.0003–0.011). Based on CBPI data, the rate of success at 60 days was 75% and 25% in the ADSC and PRP groups (P=0.13), respectively. Both therapies were apparently safe and effective to reduce chronic pain in dogs with bilateral DHJD during a 60-day period. However, a trend towards greater improvement was provided by the ADSC treatment. |
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Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cellsCanineHip dysplasiaMesenchymal stem cellsOsteoarthritisPlatelet-rich plasmaThis prospective, comparative, randomized, horizontal, and double-blind clinical study investigated the clinical efficacy of leucocyte-poor platelet-rich plasma (PRP, n=8) or allogeneic adipose-derived stem cells (ADSC, n=8) in dogs with bilateral degenerative hip joint disease (DHJD). Sixteen dogs were treated with two intra-articular injections of PRP or ADSCs, within a 30-day interval. The Canine Brief Pain Inventory (CBPI), the Helsinki Chronic Pain Index (HCPI), and Visual Analogue Scales for pain (VAS-pain) and locomotion (VAS-loc) were assessed by the dog owners. Analysis-of-gait using a force plate, response to palpation (VAS-palp), and the descriptive numerical scale for pain (DNS) were measured by a veterinarian. The assessments were performed before (baseline), 30 and 60 days after the first treatment. Data were analyzed using the unpaired t test, paired Wilcoxon test, Fisher’s exact test, and Mann-Whitney and Friedman tests (P<0.05). Compared with baseline HCPI, CBPI, VAS-pain, and VAS-palp scores reduced 41%, 52%, 51%, and 48% (P=0.0001–0.03) at 60 days in the ADSC group. In PRP-treated dogs, CBPI, VAS-loc, and DNS scores decreased by 43%, 43%, and 33% at 60 days, respectively (P=0.0003–0.011). Based on CBPI data, the rate of success at 60 days was 75% and 25% in the ADSC and PRP groups (P=0.13), respectively. Both therapies were apparently safe and effective to reduce chronic pain in dogs with bilateral DHJD during a 60-day period. However, a trend towards greater improvement was provided by the ADSC treatment.Department of Veterinary Surgery and Animal Reproduction Department of Veterinary Clinics São Paulo State University (Unesp) School of Veterinary Medicine and Animal ScienceDepartment of Veterinary Surgery and Anesthesiology Faculty of Veterinary Medicine Universidade do Oeste PaulistaDepartment of Veterinary Surgery and Animal Reproduction Department of Veterinary Clinics São Paulo State University (Unesp) School of Veterinary Medicine and Animal ScienceUniversidade Estadual Paulista (Unesp)Universidade do Oeste PaulistaOkamoto-Okubo, Celina Emiko [UNESP]Cassu, Renata NavarroJoaquim, Jean Guilherme Fernandes [UNESP]Dos Reis Mesquita, Luciane [UNESP]Rahal, Sheila Canevese [UNESP]Oliveira, Hugo S Salvador [UNESP]Takahira, Regina [UNESP]Arruda, Isadora [UNESP]Maia, Leandro [UNESP]da CRUZ LANDIM, Fernanda [UNESP]Luna, Stelio Pacca Loureiro [UNESP]2021-06-25T11:01:15Z2021-06-25T11:01:15Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article881-888http://dx.doi.org/10.1292/jvms.20-0730Journal of Veterinary Medical Science, v. 83, n. 5, p. 881-888, 2021.1347-74390916-7250http://hdl.handle.net/11449/20779910.1292/jvms.20-07302-s2.0-85106882302Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Veterinary Medical Scienceinfo:eu-repo/semantics/openAccess2024-09-09T14:00:56Zoai:repositorio.unesp.br:11449/207799Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:00:56Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells |
title |
Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells |
spellingShingle |
Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells Okamoto-Okubo, Celina Emiko [UNESP] Canine Hip dysplasia Mesenchymal stem cells Osteoarthritis Platelet-rich plasma |
title_short |
Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells |
title_full |
Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells |
title_fullStr |
Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells |
title_full_unstemmed |
Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells |
title_sort |
Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells |
author |
Okamoto-Okubo, Celina Emiko [UNESP] |
author_facet |
Okamoto-Okubo, Celina Emiko [UNESP] Cassu, Renata Navarro Joaquim, Jean Guilherme Fernandes [UNESP] Dos Reis Mesquita, Luciane [UNESP] Rahal, Sheila Canevese [UNESP] Oliveira, Hugo S Salvador [UNESP] Takahira, Regina [UNESP] Arruda, Isadora [UNESP] Maia, Leandro [UNESP] da CRUZ LANDIM, Fernanda [UNESP] Luna, Stelio Pacca Loureiro [UNESP] |
author_role |
author |
author2 |
Cassu, Renata Navarro Joaquim, Jean Guilherme Fernandes [UNESP] Dos Reis Mesquita, Luciane [UNESP] Rahal, Sheila Canevese [UNESP] Oliveira, Hugo S Salvador [UNESP] Takahira, Regina [UNESP] Arruda, Isadora [UNESP] Maia, Leandro [UNESP] da CRUZ LANDIM, Fernanda [UNESP] Luna, Stelio Pacca Loureiro [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade do Oeste Paulista |
dc.contributor.author.fl_str_mv |
Okamoto-Okubo, Celina Emiko [UNESP] Cassu, Renata Navarro Joaquim, Jean Guilherme Fernandes [UNESP] Dos Reis Mesquita, Luciane [UNESP] Rahal, Sheila Canevese [UNESP] Oliveira, Hugo S Salvador [UNESP] Takahira, Regina [UNESP] Arruda, Isadora [UNESP] Maia, Leandro [UNESP] da CRUZ LANDIM, Fernanda [UNESP] Luna, Stelio Pacca Loureiro [UNESP] |
dc.subject.por.fl_str_mv |
Canine Hip dysplasia Mesenchymal stem cells Osteoarthritis Platelet-rich plasma |
topic |
Canine Hip dysplasia Mesenchymal stem cells Osteoarthritis Platelet-rich plasma |
description |
This prospective, comparative, randomized, horizontal, and double-blind clinical study investigated the clinical efficacy of leucocyte-poor platelet-rich plasma (PRP, n=8) or allogeneic adipose-derived stem cells (ADSC, n=8) in dogs with bilateral degenerative hip joint disease (DHJD). Sixteen dogs were treated with two intra-articular injections of PRP or ADSCs, within a 30-day interval. The Canine Brief Pain Inventory (CBPI), the Helsinki Chronic Pain Index (HCPI), and Visual Analogue Scales for pain (VAS-pain) and locomotion (VAS-loc) were assessed by the dog owners. Analysis-of-gait using a force plate, response to palpation (VAS-palp), and the descriptive numerical scale for pain (DNS) were measured by a veterinarian. The assessments were performed before (baseline), 30 and 60 days after the first treatment. Data were analyzed using the unpaired t test, paired Wilcoxon test, Fisher’s exact test, and Mann-Whitney and Friedman tests (P<0.05). Compared with baseline HCPI, CBPI, VAS-pain, and VAS-palp scores reduced 41%, 52%, 51%, and 48% (P=0.0001–0.03) at 60 days in the ADSC group. In PRP-treated dogs, CBPI, VAS-loc, and DNS scores decreased by 43%, 43%, and 33% at 60 days, respectively (P=0.0003–0.011). Based on CBPI data, the rate of success at 60 days was 75% and 25% in the ADSC and PRP groups (P=0.13), respectively. Both therapies were apparently safe and effective to reduce chronic pain in dogs with bilateral DHJD during a 60-day period. However, a trend towards greater improvement was provided by the ADSC treatment. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:01:15Z 2021-06-25T11:01:15Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1292/jvms.20-0730 Journal of Veterinary Medical Science, v. 83, n. 5, p. 881-888, 2021. 1347-7439 0916-7250 http://hdl.handle.net/11449/207799 10.1292/jvms.20-0730 2-s2.0-85106882302 |
url |
http://dx.doi.org/10.1292/jvms.20-0730 http://hdl.handle.net/11449/207799 |
identifier_str_mv |
Journal of Veterinary Medical Science, v. 83, n. 5, p. 881-888, 2021. 1347-7439 0916-7250 10.1292/jvms.20-0730 2-s2.0-85106882302 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Veterinary Medical Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
881-888 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546564592861184 |