Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach

Detalhes bibliográficos
Autor(a) principal: Guiraldello, Rafael T. [UNESP]
Data de Publicação: 2016
Outros Autores: Martins, Marcelo L., Mancera, Paulo F. A. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.physa.2016.03.019
http://hdl.handle.net/11449/161543
Resumo: We present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two chemotherapeutic protocols, Maximum Tolerated Dose (MTD) and metronomic, as well as two methods of drug delivery. Concerning therapeutic outcomes, the metronomic protocol proves more effective in prolonging the patient's life than MTD. Moreover, a uniform drug delivery method combined with the metronomic protocol is the most efficient strategy to reduce tumor density. (C) 2016 Elsevier B.V. All rights reserved.
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spelling Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approachMathematical oncologyCancerTumor-induced angiogenesisChemotherapyWe present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two chemotherapeutic protocols, Maximum Tolerated Dose (MTD) and metronomic, as well as two methods of drug delivery. Concerning therapeutic outcomes, the metronomic protocol proves more effective in prolonging the patient's life than MTD. Moreover, a uniform drug delivery method combined with the metronomic protocol is the most efficient strategy to reduce tumor density. (C) 2016 Elsevier B.V. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação para o Desenvolvimento da UNESP (FUNDUNESP)Univ Estadual Paulista, Dept Bioestat, BR-18618689 Botucatu, SP, BrazilUniv Fed Vicosa, Dept Fis, BR-36570900 Vicosa, MG, BrazilUniv Estadual Paulista, Dept Bioestat, BR-18618689 Botucatu, SP, BrazilFAPESP: 2013/08133-0FAPESP: 2009/15098-0FAPEMIG: APQ-04232-10CNPq: 306024/2013-6FUNDUNESP: 1886/009-13Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade Federal de Viçosa (UFV)Guiraldello, Rafael T. [UNESP]Martins, Marcelo L.Mancera, Paulo F. A. [UNESP]2018-11-26T16:33:10Z2018-11-26T16:33:10Z2016-08-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article145-156application/pdfhttp://dx.doi.org/10.1016/j.physa.2016.03.019Physica A-statistical Mechanics And Its Applications. Amsterdam: Elsevier Science Bv, v. 456, p. 145-156, 2016.0378-4371http://hdl.handle.net/11449/16154310.1016/j.physa.2016.03.019WOS:000376693500015WOS000376693500015.pdf82322894121087230000-0002-2080-8053Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysica A-statistical Mechanics And Its Applications0,773info:eu-repo/semantics/openAccess2023-10-02T06:04:33Zoai:repositorio.unesp.br:11449/161543Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:45:50.618493Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
title Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
spellingShingle Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
Guiraldello, Rafael T. [UNESP]
Mathematical oncology
Cancer
Tumor-induced angiogenesis
Chemotherapy
title_short Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
title_full Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
title_fullStr Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
title_full_unstemmed Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
title_sort Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
author Guiraldello, Rafael T. [UNESP]
author_facet Guiraldello, Rafael T. [UNESP]
Martins, Marcelo L.
Mancera, Paulo F. A. [UNESP]
author_role author
author2 Martins, Marcelo L.
Mancera, Paulo F. A. [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Viçosa (UFV)
dc.contributor.author.fl_str_mv Guiraldello, Rafael T. [UNESP]
Martins, Marcelo L.
Mancera, Paulo F. A. [UNESP]
dc.subject.por.fl_str_mv Mathematical oncology
Cancer
Tumor-induced angiogenesis
Chemotherapy
topic Mathematical oncology
Cancer
Tumor-induced angiogenesis
Chemotherapy
description We present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two chemotherapeutic protocols, Maximum Tolerated Dose (MTD) and metronomic, as well as two methods of drug delivery. Concerning therapeutic outcomes, the metronomic protocol proves more effective in prolonging the patient's life than MTD. Moreover, a uniform drug delivery method combined with the metronomic protocol is the most efficient strategy to reduce tumor density. (C) 2016 Elsevier B.V. All rights reserved.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-15
2018-11-26T16:33:10Z
2018-11-26T16:33:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.physa.2016.03.019
Physica A-statistical Mechanics And Its Applications. Amsterdam: Elsevier Science Bv, v. 456, p. 145-156, 2016.
0378-4371
http://hdl.handle.net/11449/161543
10.1016/j.physa.2016.03.019
WOS:000376693500015
WOS000376693500015.pdf
8232289412108723
0000-0002-2080-8053
url http://dx.doi.org/10.1016/j.physa.2016.03.019
http://hdl.handle.net/11449/161543
identifier_str_mv Physica A-statistical Mechanics And Its Applications. Amsterdam: Elsevier Science Bv, v. 456, p. 145-156, 2016.
0378-4371
10.1016/j.physa.2016.03.019
WOS:000376693500015
WOS000376693500015.pdf
8232289412108723
0000-0002-2080-8053
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Physica A-statistical Mechanics And Its Applications
0,773
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 145-156
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128273204379648

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