Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1413-81232023286.16112022 http://hdl.handle.net/11449/248912 |
Resumo: | Brazil has a huge number of cases and deaths due to coronavirus disease 2019 (COVID-19); however, few studies have dealt with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among familial contacts in Brazil. Here, we report our findings on transmission in a family-based study in Bauru, São Paulo, Brazil. The study, conducted from July to November 2020, comprised 974 individuals with 233 index patients and 741 familial contacts. Familial contacts were evaluated using the rapid COVID-19 Ag ECO and reverse transcription-polymerase chain reaction (RT-PCR) tests immediately after the index patient diagnosis. The antigen-based rapid test was validated in 121 individuals using RT-PCR as the gold standard. Additionally, 30 days later, familial contacts were evaluated for IgM and IgG antibodies against SARS-CoV-2. We found 333 cases of COVID-19 among familial contacts (44.9%). A positive correlation was observed between the time elapsed from the onset of symptoms until the index patient’s COVID-19 testing and the number of family contacts infected by SARS-CoV-2. Early SARSCoV-2 testing and familial contact evaluation are relevant strategies to contain transmission. |
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Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2Tempo entre o início dos sintomas e a testagem está relacionado à maior transmissão de SARS-CoV-2 entre contatos familiaresCOVID-19PandemicSARS-CoV-2Brazil has a huge number of cases and deaths due to coronavirus disease 2019 (COVID-19); however, few studies have dealt with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among familial contacts in Brazil. Here, we report our findings on transmission in a family-based study in Bauru, São Paulo, Brazil. The study, conducted from July to November 2020, comprised 974 individuals with 233 index patients and 741 familial contacts. Familial contacts were evaluated using the rapid COVID-19 Ag ECO and reverse transcription-polymerase chain reaction (RT-PCR) tests immediately after the index patient diagnosis. The antigen-based rapid test was validated in 121 individuals using RT-PCR as the gold standard. Additionally, 30 days later, familial contacts were evaluated for IgM and IgG antibodies against SARS-CoV-2. We found 333 cases of COVID-19 among familial contacts (44.9%). A positive correlation was observed between the time elapsed from the onset of symptoms until the index patient’s COVID-19 testing and the number of family contacts infected by SARS-CoV-2. Early SARSCoV-2 testing and familial contact evaluation are relevant strategies to contain transmission.Instituto Lauro de Souza Lima Secretaria de Estado da Saúde, Rod. Cmte. João Ribeiro de Barros s/n, Distrito Industrial Marcus Vinícius Feliz Machado, SPPrograma de PósGraduação em Doenças Tropicais Faculdade de Medicina de Botucatu Universidade Estadual Paulista “Julio de Mesquita Filho” (Unesp), SPDepartamento de Infectologia Faculdade de Medicina de Botucatu Unesp, SPPrograma de PósGraduação em Doenças Tropicais Faculdade de Medicina de Botucatu Universidade Estadual Paulista “Julio de Mesquita Filho” (Unesp), SPDepartamento de Infectologia Faculdade de Medicina de Botucatu Unesp, SPSecretaria de Estado da SaúdeUniversidade Estadual Paulista (UNESP)Menezes, Daiane Cabrera [UNESP]Perico, Jonatas [UNESP]Martins, Bruna Letícia [UNESP]Belone, Andrea de Faria FernandesFortaleza, Carlos Magno Castelo Branco [UNESP]Santana, Fabiana Covolo de SouzaLatini, Ana Carla Pereira [UNESP]de Souza, Vania Nieto Brito [UNESP]2023-07-29T13:57:09Z2023-07-29T13:57:09Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1751-1756http://dx.doi.org/10.1590/1413-81232023286.16112022Ciencia e Saude Coletiva, v. 28, n. 6, p. 1751-1756, 2023.1678-45611413-8123http://hdl.handle.net/11449/24891210.1590/1413-81232023286.161120222-s2.0-85160617116Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCiencia e Saude Coletivainfo:eu-repo/semantics/openAccess2024-08-15T15:23:01Zoai:repositorio.unesp.br:11449/248912Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2 Tempo entre o início dos sintomas e a testagem está relacionado à maior transmissão de SARS-CoV-2 entre contatos familiares |
title |
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2 |
spellingShingle |
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2 Menezes, Daiane Cabrera [UNESP] COVID-19 Pandemic SARS-CoV-2 |
title_short |
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2 |
title_full |
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2 |
title_fullStr |
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2 |
title_full_unstemmed |
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2 |
title_sort |
Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2 |
author |
Menezes, Daiane Cabrera [UNESP] |
author_facet |
Menezes, Daiane Cabrera [UNESP] Perico, Jonatas [UNESP] Martins, Bruna Letícia [UNESP] Belone, Andrea de Faria Fernandes Fortaleza, Carlos Magno Castelo Branco [UNESP] Santana, Fabiana Covolo de Souza Latini, Ana Carla Pereira [UNESP] de Souza, Vania Nieto Brito [UNESP] |
author_role |
author |
author2 |
Perico, Jonatas [UNESP] Martins, Bruna Letícia [UNESP] Belone, Andrea de Faria Fernandes Fortaleza, Carlos Magno Castelo Branco [UNESP] Santana, Fabiana Covolo de Souza Latini, Ana Carla Pereira [UNESP] de Souza, Vania Nieto Brito [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Secretaria de Estado da Saúde Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Menezes, Daiane Cabrera [UNESP] Perico, Jonatas [UNESP] Martins, Bruna Letícia [UNESP] Belone, Andrea de Faria Fernandes Fortaleza, Carlos Magno Castelo Branco [UNESP] Santana, Fabiana Covolo de Souza Latini, Ana Carla Pereira [UNESP] de Souza, Vania Nieto Brito [UNESP] |
dc.subject.por.fl_str_mv |
COVID-19 Pandemic SARS-CoV-2 |
topic |
COVID-19 Pandemic SARS-CoV-2 |
description |
Brazil has a huge number of cases and deaths due to coronavirus disease 2019 (COVID-19); however, few studies have dealt with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among familial contacts in Brazil. Here, we report our findings on transmission in a family-based study in Bauru, São Paulo, Brazil. The study, conducted from July to November 2020, comprised 974 individuals with 233 index patients and 741 familial contacts. Familial contacts were evaluated using the rapid COVID-19 Ag ECO and reverse transcription-polymerase chain reaction (RT-PCR) tests immediately after the index patient diagnosis. The antigen-based rapid test was validated in 121 individuals using RT-PCR as the gold standard. Additionally, 30 days later, familial contacts were evaluated for IgM and IgG antibodies against SARS-CoV-2. We found 333 cases of COVID-19 among familial contacts (44.9%). A positive correlation was observed between the time elapsed from the onset of symptoms until the index patient’s COVID-19 testing and the number of family contacts infected by SARS-CoV-2. Early SARSCoV-2 testing and familial contact evaluation are relevant strategies to contain transmission. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:57:09Z 2023-07-29T13:57:09Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1413-81232023286.16112022 Ciencia e Saude Coletiva, v. 28, n. 6, p. 1751-1756, 2023. 1678-4561 1413-8123 http://hdl.handle.net/11449/248912 10.1590/1413-81232023286.16112022 2-s2.0-85160617116 |
url |
http://dx.doi.org/10.1590/1413-81232023286.16112022 http://hdl.handle.net/11449/248912 |
identifier_str_mv |
Ciencia e Saude Coletiva, v. 28, n. 6, p. 1751-1756, 2023. 1678-4561 1413-8123 10.1590/1413-81232023286.16112022 2-s2.0-85160617116 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ciencia e Saude Coletiva |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1751-1756 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128163866214400 |