Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos

Detalhes bibliográficos
Autor(a) principal: Bonfietti, Luiz Henrique Ferreira dos Santos [UNESP]
Data de Publicação: 2013
Tipo de documento: Trabalho de conclusão de curso
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/149611
http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-30/000856477.pdf
Resumo: The aim of this study is to evaluate histomorphometrically, the use of sodium alendronate (SA) as adjunctive therapy for the treatment of mechanical scaling and root planing (SRP) periodontal disease (PD) in rats. The DP was induced by placing a ligature thread around the first molars of 90 male rats . After 7 days of placing the ligature, the animals were divided into 3 groups of 30 animals and following treatments: Group ST - Only the removal of the ligature; SRP Group - Removal of ligature followed by SRP and irrigation with 1 ml of saline solution; and Group SRP + SA - Removal of ligatur followed by SRP and irrigation with 1 mL of SA ( 10 - 5M ) . Ten animals from each group were euthanized at 7, 15 and 30 days after removal of the ligature. To analyze the results obtained were semi -serial sections with a thickness of 4 mμ for histomorphometric analysis. In the ST group at 7 days, an intense inflammatory infiltrate was present and all specimens showed spicules of necrotic bone in the furcation area with great osteoclastic activity. At 15 and 30 days was still intense inflammation and bone interradicular still had osteoclastic activity and resorptive areas in the cement. In SRP Group to 7 days, the tissue showed less inflammatory infiltrate compared to the ST Group . At 15 and 30 days there was a reduction in the volume occupied by the inflammatory infiltrate progressively. RAR + AS Group, at 7 days, the inflammatory infiltrate was fairly discreet, the septum interradicular showed up with a regular outline and rare osteoclasts were observed . At 15 and 30 days showed the tissue was free of inflammation with collagen, including those which fell within the cementum and alveolar bone. The septum interradicular presented fairly regular with vital osteocytes and osteoclasts were rare. Areas of active resorption were observed...
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spelling Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratosDoenças periodontaisAlendronatoRaspagem dentáriaPeriodontal diseasesThe aim of this study is to evaluate histomorphometrically, the use of sodium alendronate (SA) as adjunctive therapy for the treatment of mechanical scaling and root planing (SRP) periodontal disease (PD) in rats. The DP was induced by placing a ligature thread around the first molars of 90 male rats . After 7 days of placing the ligature, the animals were divided into 3 groups of 30 animals and following treatments: Group ST - Only the removal of the ligature; SRP Group - Removal of ligature followed by SRP and irrigation with 1 ml of saline solution; and Group SRP + SA - Removal of ligatur followed by SRP and irrigation with 1 mL of SA ( 10 - 5M ) . Ten animals from each group were euthanized at 7, 15 and 30 days after removal of the ligature. To analyze the results obtained were semi -serial sections with a thickness of 4 mμ for histomorphometric analysis. In the ST group at 7 days, an intense inflammatory infiltrate was present and all specimens showed spicules of necrotic bone in the furcation area with great osteoclastic activity. At 15 and 30 days was still intense inflammation and bone interradicular still had osteoclastic activity and resorptive areas in the cement. In SRP Group to 7 days, the tissue showed less inflammatory infiltrate compared to the ST Group . At 15 and 30 days there was a reduction in the volume occupied by the inflammatory infiltrate progressively. RAR + AS Group, at 7 days, the inflammatory infiltrate was fairly discreet, the septum interradicular showed up with a regular outline and rare osteoclasts were observed . At 15 and 30 days showed the tissue was free of inflammation with collagen, including those which fell within the cementum and alveolar bone. The septum interradicular presented fairly regular with vital osteocytes and osteoclasts were rare. Areas of active resorption were observed...Constitui propósito do presente estudo avaliar histomorfometricamente, o uso do alendronato de sódio como terapia coadjuvante ao tratamento mecânico de Raspagem e Alisamento Radicular (RAR) da doença periodontal (DP) experimental em ratos. A DP foi induzida pela adaptação de um fio de algodão ao redor dos primeiros molares inferiores de 90 ratos machos. Decorridos 7 dias, a ligadura foi removida e os animais foram divididos em 3 grupos experimentais de 30 animais e submetidos aos seguintes procedimentos: Grupo ST - sem tratamento periodontal local; Grupo RAR - RAR e irrigação com 1 ml de soro fisiológico; Grupo RAR + AS - RAR e irrigação com 1 ml de alendronato de sódio (10-5M). Dez animais de cada grupo foram eutanasiados aos 7, 15 e 30 dias após remoção da ligadura. As hemimandíbulas foram submetidas ao processamento histológico para análise histológica e histométrica da porcentagem de osso na região de furca (POF). No Grupo ST aos 7 dias, um intenso infiltrado inflamatório estava presente e todos os espécimes apresentavam espículas de osso necrosado na região de furca com grande atividade osteoclástica. Aos 15 e 30 dias a inflamação ainda era intensa e o tecido ósseo interradicular ainda apresentava atividade osteoclástica e áreas reabsortivas no cemento. No Grupo RAR aos 7 dias, o tecido conjuntivo apresentou menor infiltrado inflamatório comparado ao grupo ST. Aos 15 e 30 dias houve uma redução progressiva do volume ocupado pelo infiltrado inflamatório. No grupo RAR + AS, aos 7 dias, o infiltrado inflamatório mostrou-se bastante discreto, o septo interradicular mostrou-se com um contorno regular e raros foram os osteoclastos observados. Aos 15 e 30 dias, o tecido conjuntivo mostrou-se isento de inflamação, com grande quantidade de fibras colágenas, incluindo aquelas que...Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista (Unesp)Almeida, Juliano Milanezi de [UNESP]Miyahara, Glauco Issamu [UNESP]Universidade Estadual Paulista (Unesp)Bonfietti, Luiz Henrique Ferreira dos Santos [UNESP]2017-03-14T14:47:24Z2017-03-14T14:47:24Z2013-09-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesis49 f.application/pdfBONFIETTI, Luiz Henrique Ferreira dos Santos. Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos. 2013. 49 f. Trabalho de conclusão de curso (bacharelado - Odontologia) - Universidade Estadual Paulista Julio de Mesquita Filho, Faculdade de Odontologia de Araçatuba, 2013.http://hdl.handle.net/11449/149611000856477http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-30/000856477.pdf4146341015030248Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2023-12-26T06:22:44Zoai:repositorio.unesp.br:11449/149611Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-26T06:22:44Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos
title Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos
spellingShingle Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos
Bonfietti, Luiz Henrique Ferreira dos Santos [UNESP]
Doenças periodontais
Alendronato
Raspagem dentária
Periodontal diseases
title_short Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos
title_full Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos
title_fullStr Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos
title_full_unstemmed Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos
title_sort Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos
author Bonfietti, Luiz Henrique Ferreira dos Santos [UNESP]
author_facet Bonfietti, Luiz Henrique Ferreira dos Santos [UNESP]
author_role author
dc.contributor.none.fl_str_mv Almeida, Juliano Milanezi de [UNESP]
Miyahara, Glauco Issamu [UNESP]
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Bonfietti, Luiz Henrique Ferreira dos Santos [UNESP]
dc.subject.por.fl_str_mv Doenças periodontais
Alendronato
Raspagem dentária
Periodontal diseases
topic Doenças periodontais
Alendronato
Raspagem dentária
Periodontal diseases
description The aim of this study is to evaluate histomorphometrically, the use of sodium alendronate (SA) as adjunctive therapy for the treatment of mechanical scaling and root planing (SRP) periodontal disease (PD) in rats. The DP was induced by placing a ligature thread around the first molars of 90 male rats . After 7 days of placing the ligature, the animals were divided into 3 groups of 30 animals and following treatments: Group ST - Only the removal of the ligature; SRP Group - Removal of ligature followed by SRP and irrigation with 1 ml of saline solution; and Group SRP + SA - Removal of ligatur followed by SRP and irrigation with 1 mL of SA ( 10 - 5M ) . Ten animals from each group were euthanized at 7, 15 and 30 days after removal of the ligature. To analyze the results obtained were semi -serial sections with a thickness of 4 mμ for histomorphometric analysis. In the ST group at 7 days, an intense inflammatory infiltrate was present and all specimens showed spicules of necrotic bone in the furcation area with great osteoclastic activity. At 15 and 30 days was still intense inflammation and bone interradicular still had osteoclastic activity and resorptive areas in the cement. In SRP Group to 7 days, the tissue showed less inflammatory infiltrate compared to the ST Group . At 15 and 30 days there was a reduction in the volume occupied by the inflammatory infiltrate progressively. RAR + AS Group, at 7 days, the inflammatory infiltrate was fairly discreet, the septum interradicular showed up with a regular outline and rare osteoclasts were observed . At 15 and 30 days showed the tissue was free of inflammation with collagen, including those which fell within the cementum and alveolar bone. The septum interradicular presented fairly regular with vital osteocytes and osteoclasts were rare. Areas of active resorption were observed...
publishDate 2013
dc.date.none.fl_str_mv 2013-09-13
2017-03-14T14:47:24Z
2017-03-14T14:47:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv BONFIETTI, Luiz Henrique Ferreira dos Santos. Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos. 2013. 49 f. Trabalho de conclusão de curso (bacharelado - Odontologia) - Universidade Estadual Paulista Julio de Mesquita Filho, Faculdade de Odontologia de Araçatuba, 2013.
http://hdl.handle.net/11449/149611
000856477
http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-30/000856477.pdf
4146341015030248
identifier_str_mv BONFIETTI, Luiz Henrique Ferreira dos Santos. Terapia coadjuvante com alendronato de sódio no tratamento da doença periodontal experimental em ratos. 2013. 49 f. Trabalho de conclusão de curso (bacharelado - Odontologia) - Universidade Estadual Paulista Julio de Mesquita Filho, Faculdade de Odontologia de Araçatuba, 2013.
000856477
4146341015030248
url http://hdl.handle.net/11449/149611
http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-30/000856477.pdf
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv 49 f.
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dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.source.none.fl_str_mv Aleph
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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instname_str Universidade Estadual Paulista (UNESP)
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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