Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.17807/orbital.v7i3.739 http://hdl.handle.net/11449/160636 |
Resumo: | Thyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology. |
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Repositório Institucional da UNESP |
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Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulatorsthyroid hormonesnuclear receptorligandssynthesisThyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed ABC, Ctr Ciencias Nat & Humanas, Rua Santa Adelia 166, BR-09210170 Santo Andre, SP, BrazilUniv Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP, BrazilUniv Estadual Paulista, Fac Engn, Dept Fis & Quim, BR-15385000 Ilha Solteira, SP, BrazilUniv Sao Paulo, Inst Fis Sao Carlos, Dept Fis & Informat, BR-13566590 Sao Carlos, SP, BrazilUniv Estadual Paulista, Fac Engn, Dept Fis & Quim, BR-15385000 Ilha Solteira, SP, BrazilUniv Federal Mato Grosso Sul, Dept QuimicaUniversidade Federal do ABC (UFABC)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Castro, Guilherme Vieira deRomero Rocha, Carlos MuriloSanches, Vitor LacerdaZana Ribeiro, Pedro H.Donate, Paulo Marcoslaurentiz, Rosangela da Silva de [UNESP]Polikarpov, IgorSairre, Mirela I.2018-11-26T16:05:25Z2018-11-26T16:05:25Z2015-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article282-291application/pdfhttp://dx.doi.org/10.17807/orbital.v7i3.739Orbital-the Electronic Journal Of Chemistry. Campo Grande: Univ Federal Mato Grosso Sul, Dept Quimica, v. 7, n. 3, p. 282-291, 2015.1984-6428http://hdl.handle.net/11449/16063610.17807/orbital.v7i3.739WOS:000219762300011WOS000219762300011.pdf79898377279107590000-0002-5240-4870Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOrbital-the Electronic Journal Of Chemistryinfo:eu-repo/semantics/openAccess2024-07-10T14:07:29Zoai:repositorio.unesp.br:11449/160636Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:45:17.364398Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
title |
Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
spellingShingle |
Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators Castro, Guilherme Vieira de thyroid hormones nuclear receptor ligands synthesis |
title_short |
Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
title_full |
Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
title_fullStr |
Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
title_full_unstemmed |
Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
title_sort |
Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
author |
Castro, Guilherme Vieira de |
author_facet |
Castro, Guilherme Vieira de Romero Rocha, Carlos Murilo Sanches, Vitor Lacerda Zana Ribeiro, Pedro H. Donate, Paulo Marcos laurentiz, Rosangela da Silva de [UNESP] Polikarpov, Igor Sairre, Mirela I. |
author_role |
author |
author2 |
Romero Rocha, Carlos Murilo Sanches, Vitor Lacerda Zana Ribeiro, Pedro H. Donate, Paulo Marcos laurentiz, Rosangela da Silva de [UNESP] Polikarpov, Igor Sairre, Mirela I. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do ABC (UFABC) Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Castro, Guilherme Vieira de Romero Rocha, Carlos Murilo Sanches, Vitor Lacerda Zana Ribeiro, Pedro H. Donate, Paulo Marcos laurentiz, Rosangela da Silva de [UNESP] Polikarpov, Igor Sairre, Mirela I. |
dc.subject.por.fl_str_mv |
thyroid hormones nuclear receptor ligands synthesis |
topic |
thyroid hormones nuclear receptor ligands synthesis |
description |
Thyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-01 2018-11-26T16:05:25Z 2018-11-26T16:05:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.17807/orbital.v7i3.739 Orbital-the Electronic Journal Of Chemistry. Campo Grande: Univ Federal Mato Grosso Sul, Dept Quimica, v. 7, n. 3, p. 282-291, 2015. 1984-6428 http://hdl.handle.net/11449/160636 10.17807/orbital.v7i3.739 WOS:000219762300011 WOS000219762300011.pdf 7989837727910759 0000-0002-5240-4870 |
url |
http://dx.doi.org/10.17807/orbital.v7i3.739 http://hdl.handle.net/11449/160636 |
identifier_str_mv |
Orbital-the Electronic Journal Of Chemistry. Campo Grande: Univ Federal Mato Grosso Sul, Dept Quimica, v. 7, n. 3, p. 282-291, 2015. 1984-6428 10.17807/orbital.v7i3.739 WOS:000219762300011 WOS000219762300011.pdf 7989837727910759 0000-0002-5240-4870 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Orbital-the Electronic Journal Of Chemistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
282-291 application/pdf |
dc.publisher.none.fl_str_mv |
Univ Federal Mato Grosso Sul, Dept Quimica |
publisher.none.fl_str_mv |
Univ Federal Mato Grosso Sul, Dept Quimica |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128696227201024 |