Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.mito.2017.02.001 http://hdl.handle.net/11449/162831 |
Resumo: | We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A +T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype. (C) 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved. |
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Repositório Institucional da UNESP |
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Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in DrosophilaMitochondrial DNAHaplotypeCybridRespirationSupercomplexesWe evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A +T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype. (C) 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.Academy of FinlandNational Institutes of HealthMarie Curie International Incoming Fellowship ProgramFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Tampere, Inst Biosci & Med Technol, FI-331014 Tampere, FinlandMichigan State Univ, Dept Biochem & Mol Biol, Ctr Mitochondrial Sci & Med, E Lansing, MI 48824 USAUniv Estadual Paulista, Dept Tecnol, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, BrazilUniv Helsinki, Inst Biotechnol, FI-00014 Helsinki, FinlandUniv Estadual Paulista, Dept Tecnol, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, BrazilNational Institutes of Health: GM45295Marie Curie International Incoming Fellowship Program: 328988FAPESP: 2014/02253-6Elsevier B.V.Univ TampereMichigan State UnivUniversidade Estadual Paulista (Unesp)Univ HelsinkiSalminen, Tiina S.Oliveira, Marcos T. [UNESP]Cannino, GiuseppeLillsunde, PaiviJacobs, Howard T.Kaguni, Laurie S.2018-11-26T17:33:01Z2018-11-26T17:33:01Z2017-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article75-83application/pdfhttp://dx.doi.org/10.1016/j.mito.2017.02.001Mitochondrion. Oxford: Elsevier Sci Ltd, v. 34, p. 75-83, 2017.1567-7249http://hdl.handle.net/11449/16283110.1016/j.mito.2017.02.001WOS:000402023900011WOS000402023900011.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMitochondrion1,666info:eu-repo/semantics/openAccess2024-06-07T15:32:49Zoai:repositorio.unesp.br:11449/162831Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:05:54.278946Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila |
title |
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila |
spellingShingle |
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila Salminen, Tiina S. Mitochondrial DNA Haplotype Cybrid Respiration Supercomplexes |
title_short |
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila |
title_full |
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila |
title_fullStr |
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila |
title_full_unstemmed |
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila |
title_sort |
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila |
author |
Salminen, Tiina S. |
author_facet |
Salminen, Tiina S. Oliveira, Marcos T. [UNESP] Cannino, Giuseppe Lillsunde, Paivi Jacobs, Howard T. Kaguni, Laurie S. |
author_role |
author |
author2 |
Oliveira, Marcos T. [UNESP] Cannino, Giuseppe Lillsunde, Paivi Jacobs, Howard T. Kaguni, Laurie S. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Univ Tampere Michigan State Univ Universidade Estadual Paulista (Unesp) Univ Helsinki |
dc.contributor.author.fl_str_mv |
Salminen, Tiina S. Oliveira, Marcos T. [UNESP] Cannino, Giuseppe Lillsunde, Paivi Jacobs, Howard T. Kaguni, Laurie S. |
dc.subject.por.fl_str_mv |
Mitochondrial DNA Haplotype Cybrid Respiration Supercomplexes |
topic |
Mitochondrial DNA Haplotype Cybrid Respiration Supercomplexes |
description |
We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A +T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype. (C) 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-01 2018-11-26T17:33:01Z 2018-11-26T17:33:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.mito.2017.02.001 Mitochondrion. Oxford: Elsevier Sci Ltd, v. 34, p. 75-83, 2017. 1567-7249 http://hdl.handle.net/11449/162831 10.1016/j.mito.2017.02.001 WOS:000402023900011 WOS000402023900011.pdf |
url |
http://dx.doi.org/10.1016/j.mito.2017.02.001 http://hdl.handle.net/11449/162831 |
identifier_str_mv |
Mitochondrion. Oxford: Elsevier Sci Ltd, v. 34, p. 75-83, 2017. 1567-7249 10.1016/j.mito.2017.02.001 WOS:000402023900011 WOS000402023900011.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mitochondrion 1,666 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
75-83 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129582473150464 |