Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila

Detalhes bibliográficos
Autor(a) principal: Salminen, Tiina S.
Data de Publicação: 2017
Outros Autores: Oliveira, Marcos T. [UNESP], Cannino, Giuseppe, Lillsunde, Paivi, Jacobs, Howard T., Kaguni, Laurie S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.mito.2017.02.001
http://hdl.handle.net/11449/162831
Resumo: We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A +T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype. (C) 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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spelling Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in DrosophilaMitochondrial DNAHaplotypeCybridRespirationSupercomplexesWe evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A +T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype. (C) 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.Academy of FinlandNational Institutes of HealthMarie Curie International Incoming Fellowship ProgramFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Tampere, Inst Biosci & Med Technol, FI-331014 Tampere, FinlandMichigan State Univ, Dept Biochem & Mol Biol, Ctr Mitochondrial Sci & Med, E Lansing, MI 48824 USAUniv Estadual Paulista, Dept Tecnol, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, BrazilUniv Helsinki, Inst Biotechnol, FI-00014 Helsinki, FinlandUniv Estadual Paulista, Dept Tecnol, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, BrazilNational Institutes of Health: GM45295Marie Curie International Incoming Fellowship Program: 328988FAPESP: 2014/02253-6Elsevier B.V.Univ TampereMichigan State UnivUniversidade Estadual Paulista (Unesp)Univ HelsinkiSalminen, Tiina S.Oliveira, Marcos T. [UNESP]Cannino, GiuseppeLillsunde, PaiviJacobs, Howard T.Kaguni, Laurie S.2018-11-26T17:33:01Z2018-11-26T17:33:01Z2017-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article75-83application/pdfhttp://dx.doi.org/10.1016/j.mito.2017.02.001Mitochondrion. Oxford: Elsevier Sci Ltd, v. 34, p. 75-83, 2017.1567-7249http://hdl.handle.net/11449/16283110.1016/j.mito.2017.02.001WOS:000402023900011WOS000402023900011.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMitochondrion1,666info:eu-repo/semantics/openAccess2024-01-27T06:57:38Zoai:repositorio.unesp.br:11449/162831Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-27T06:57:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
title Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
spellingShingle Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
Salminen, Tiina S.
Mitochondrial DNA
Haplotype
Cybrid
Respiration
Supercomplexes
title_short Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
title_full Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
title_fullStr Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
title_full_unstemmed Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
title_sort Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
author Salminen, Tiina S.
author_facet Salminen, Tiina S.
Oliveira, Marcos T. [UNESP]
Cannino, Giuseppe
Lillsunde, Paivi
Jacobs, Howard T.
Kaguni, Laurie S.
author_role author
author2 Oliveira, Marcos T. [UNESP]
Cannino, Giuseppe
Lillsunde, Paivi
Jacobs, Howard T.
Kaguni, Laurie S.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Tampere
Michigan State Univ
Universidade Estadual Paulista (Unesp)
Univ Helsinki
dc.contributor.author.fl_str_mv Salminen, Tiina S.
Oliveira, Marcos T. [UNESP]
Cannino, Giuseppe
Lillsunde, Paivi
Jacobs, Howard T.
Kaguni, Laurie S.
dc.subject.por.fl_str_mv Mitochondrial DNA
Haplotype
Cybrid
Respiration
Supercomplexes
topic Mitochondrial DNA
Haplotype
Cybrid
Respiration
Supercomplexes
description We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A +T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype. (C) 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
publishDate 2017
dc.date.none.fl_str_mv 2017-05-01
2018-11-26T17:33:01Z
2018-11-26T17:33:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.mito.2017.02.001
Mitochondrion. Oxford: Elsevier Sci Ltd, v. 34, p. 75-83, 2017.
1567-7249
http://hdl.handle.net/11449/162831
10.1016/j.mito.2017.02.001
WOS:000402023900011
WOS000402023900011.pdf
url http://dx.doi.org/10.1016/j.mito.2017.02.001
http://hdl.handle.net/11449/162831
identifier_str_mv Mitochondrion. Oxford: Elsevier Sci Ltd, v. 34, p. 75-83, 2017.
1567-7249
10.1016/j.mito.2017.02.001
WOS:000402023900011
WOS000402023900011.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mitochondrion
1,666
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 75-83
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965741961707520

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