Epstein-Barr Virus microRNAs in the pathogenesis of human cancers

Detalhes bibliográficos
Autor(a) principal: Caetano, Brunno Felipe Ramos
Data de Publicação: 2020
Outros Autores: Jorge, Beatrice Adrianne Silva, Müller-Coan, Bárbara Grasiele, Oliveira, Deilson Elgui de [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/202118
Resumo: The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection.
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spelling Epstein-Barr Virus microRNAs in the pathogenesis of human cancersEBV mir-BARTsEBV mir-BHRF1EBERsNasopharyngeal carcinomasLymphomasGastric carcinomasThe Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)PreprintSão Paulo State University (UNESP), Medical School of BotucatuSão Paulo State University (UNESP), Institute of Biosciences of BotucatuSão Paulo State University (UNESP), Institute of Biotechnology (IBTEC)FAPESP 2017/20352-0 (DR scholarship), 2017/22312-5 (DR scholarship), 2017/233393-9 (Research Grant), 2018/12164-1 (MSc scholarship), 2019/03804-0 (BEPE DR scholarship), 2019/05061-4 (BEPE MS scholarship)CNPq 142294/2017-9 (DR scholarship)ElsevierUniversidade Estadual Paulista (Unesp)Caetano, Brunno Felipe RamosJorge, Beatrice Adrianne SilvaMüller-Coan, Bárbara GrasieleOliveira, Deilson Elgui de [UNESP]2020-12-14T13:16:31Z2020-12-14T13:16:31Z2020-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf0304-3835http://hdl.handle.net/11449/20211810.1016/j.canlet.2020.11.01952409985698680810000-0001-5562-9648engCancer Lettersinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2024-09-03T13:15:27Zoai:repositorio.unesp.br:11449/202118Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
title Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
spellingShingle Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
Caetano, Brunno Felipe Ramos
EBV mir-BARTs
EBV mir-BHRF1
EBERs
Nasopharyngeal carcinomas
Lymphomas
Gastric carcinomas
title_short Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
title_full Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
title_fullStr Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
title_full_unstemmed Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
title_sort Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
author Caetano, Brunno Felipe Ramos
author_facet Caetano, Brunno Felipe Ramos
Jorge, Beatrice Adrianne Silva
Müller-Coan, Bárbara Grasiele
Oliveira, Deilson Elgui de [UNESP]
author_role author
author2 Jorge, Beatrice Adrianne Silva
Müller-Coan, Bárbara Grasiele
Oliveira, Deilson Elgui de [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Caetano, Brunno Felipe Ramos
Jorge, Beatrice Adrianne Silva
Müller-Coan, Bárbara Grasiele
Oliveira, Deilson Elgui de [UNESP]
dc.subject.por.fl_str_mv EBV mir-BARTs
EBV mir-BHRF1
EBERs
Nasopharyngeal carcinomas
Lymphomas
Gastric carcinomas
topic EBV mir-BARTs
EBV mir-BHRF1
EBERs
Nasopharyngeal carcinomas
Lymphomas
Gastric carcinomas
description The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-14T13:16:31Z
2020-12-14T13:16:31Z
2020-11
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 0304-3835
http://hdl.handle.net/11449/202118
10.1016/j.canlet.2020.11.019
5240998569868081
0000-0001-5562-9648
identifier_str_mv 0304-3835
10.1016/j.canlet.2020.11.019
5240998569868081
0000-0001-5562-9648
url http://hdl.handle.net/11449/202118
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cancer Letters
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1810021390064025600

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