Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/202118 |
Resumo: | The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection. |
id |
UNSP_93647b76de02c88cfa2f585b21a540ec |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/202118 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancersEBV mir-BARTsEBV mir-BHRF1EBERsNasopharyngeal carcinomasLymphomasGastric carcinomasThe Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)PreprintSão Paulo State University (UNESP), Medical School of BotucatuSão Paulo State University (UNESP), Institute of Biosciences of BotucatuSão Paulo State University (UNESP), Institute of Biotechnology (IBTEC)FAPESP 2017/20352-0 (DR scholarship), 2017/22312-5 (DR scholarship), 2017/233393-9 (Research Grant), 2018/12164-1 (MSc scholarship), 2019/03804-0 (BEPE DR scholarship), 2019/05061-4 (BEPE MS scholarship)CNPq 142294/2017-9 (DR scholarship)ElsevierUniversidade Estadual Paulista (Unesp)Caetano, Brunno Felipe RamosJorge, Beatrice Adrianne SilvaMüller-Coan, Bárbara GrasieleOliveira, Deilson Elgui de [UNESP]2020-12-14T13:16:31Z2020-12-14T13:16:31Z2020-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf0304-3835http://hdl.handle.net/11449/20211810.1016/j.canlet.2020.11.01952409985698680810000-0001-5562-9648engCancer Lettersinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2024-09-03T13:15:27Zoai:repositorio.unesp.br:11449/202118Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancers |
title |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancers |
spellingShingle |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancers Caetano, Brunno Felipe Ramos EBV mir-BARTs EBV mir-BHRF1 EBERs Nasopharyngeal carcinomas Lymphomas Gastric carcinomas |
title_short |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancers |
title_full |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancers |
title_fullStr |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancers |
title_full_unstemmed |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancers |
title_sort |
Epstein-Barr Virus microRNAs in the pathogenesis of human cancers |
author |
Caetano, Brunno Felipe Ramos |
author_facet |
Caetano, Brunno Felipe Ramos Jorge, Beatrice Adrianne Silva Müller-Coan, Bárbara Grasiele Oliveira, Deilson Elgui de [UNESP] |
author_role |
author |
author2 |
Jorge, Beatrice Adrianne Silva Müller-Coan, Bárbara Grasiele Oliveira, Deilson Elgui de [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Caetano, Brunno Felipe Ramos Jorge, Beatrice Adrianne Silva Müller-Coan, Bárbara Grasiele Oliveira, Deilson Elgui de [UNESP] |
dc.subject.por.fl_str_mv |
EBV mir-BARTs EBV mir-BHRF1 EBERs Nasopharyngeal carcinomas Lymphomas Gastric carcinomas |
topic |
EBV mir-BARTs EBV mir-BHRF1 EBERs Nasopharyngeal carcinomas Lymphomas Gastric carcinomas |
description |
The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-14T13:16:31Z 2020-12-14T13:16:31Z 2020-11 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
0304-3835 http://hdl.handle.net/11449/202118 10.1016/j.canlet.2020.11.019 5240998569868081 0000-0001-5562-9648 |
identifier_str_mv |
0304-3835 10.1016/j.canlet.2020.11.019 5240998569868081 0000-0001-5562-9648 |
url |
http://hdl.handle.net/11449/202118 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cancer Letters |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021390064025600 |