Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid

Detalhes bibliográficos
Autor(a) principal: Marona, Hérida R. N. [UNESP]
Data de Publicação: 2003
Outros Autores: Lopes, Cristiani C. G. O. [UNESP], Cardoso, Simone G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.latamjpharm.org/trabajos/22/4/LAJOP_22_4_2_1_BME2CBRX6V.pdf
http://hdl.handle.net/11449/67436
Resumo: An inexpensive, simple, precise and rapid method for the determination of fluoroquinolone gatifloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included the precision, recovery and accuracy. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay.
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spelling Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric AcidFluoroquinoloneGatifloxacinNon-aqueous titrationPharmaceutical analysisacetic acidcrystal violetexcipientgatifloxacinperchloric acidquinoline derived antiinfective agentaccuracyanalytic methoddrug determinationdrug formulationquantitative assaytablettitrimetryvalidation processweightAn inexpensive, simple, precise and rapid method for the determination of fluoroquinolone gatifloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included the precision, recovery and accuracy. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay.Prog. Pos-Graduacao Cie. Farmaceut. FCF UNESP, Araraquara, SPCentro de Ciencias da Saude UFSM, Santa Maria, RSProg. Pos-Graduacao Cie. Farmaceut. FCF UNESP, Araraquara, SPUniversidade Estadual Paulista (Unesp)Universidade Federal de Sergipe (UFS)Marona, Hérida R. N. [UNESP]Lopes, Cristiani C. G. O. [UNESP]Cardoso, Simone G.2014-05-27T11:20:55Z2014-05-27T11:20:55Z2003-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article339-342http://www.latamjpharm.org/trabajos/22/4/LAJOP_22_4_2_1_BME2CBRX6V.pdfActa Farmaceutica Bonaerense, v. 22, n. 4, p. 339-342, 2003.0326-2383http://hdl.handle.net/11449/674362-s2.0-0347123113Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Farmaceutica Bonaerense0.4010,152info:eu-repo/semantics/openAccess2021-10-23T11:33:42Zoai:repositorio.unesp.br:11449/67436Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:04:47.766150Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
title Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
spellingShingle Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
Marona, Hérida R. N. [UNESP]
Fluoroquinolone
Gatifloxacin
Non-aqueous titration
Pharmaceutical analysis
acetic acid
crystal violet
excipient
gatifloxacin
perchloric acid
quinoline derived antiinfective agent
accuracy
analytic method
drug determination
drug formulation
quantitative assay
tablet
titrimetry
validation process
weight
title_short Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
title_full Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
title_fullStr Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
title_full_unstemmed Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
title_sort Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
author Marona, Hérida R. N. [UNESP]
author_facet Marona, Hérida R. N. [UNESP]
Lopes, Cristiani C. G. O. [UNESP]
Cardoso, Simone G.
author_role author
author2 Lopes, Cristiani C. G. O. [UNESP]
Cardoso, Simone G.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Sergipe (UFS)
dc.contributor.author.fl_str_mv Marona, Hérida R. N. [UNESP]
Lopes, Cristiani C. G. O. [UNESP]
Cardoso, Simone G.
dc.subject.por.fl_str_mv Fluoroquinolone
Gatifloxacin
Non-aqueous titration
Pharmaceutical analysis
acetic acid
crystal violet
excipient
gatifloxacin
perchloric acid
quinoline derived antiinfective agent
accuracy
analytic method
drug determination
drug formulation
quantitative assay
tablet
titrimetry
validation process
weight
topic Fluoroquinolone
Gatifloxacin
Non-aqueous titration
Pharmaceutical analysis
acetic acid
crystal violet
excipient
gatifloxacin
perchloric acid
quinoline derived antiinfective agent
accuracy
analytic method
drug determination
drug formulation
quantitative assay
tablet
titrimetry
validation process
weight
description An inexpensive, simple, precise and rapid method for the determination of fluoroquinolone gatifloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included the precision, recovery and accuracy. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay.
publishDate 2003
dc.date.none.fl_str_mv 2003-10-01
2014-05-27T11:20:55Z
2014-05-27T11:20:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.latamjpharm.org/trabajos/22/4/LAJOP_22_4_2_1_BME2CBRX6V.pdf
Acta Farmaceutica Bonaerense, v. 22, n. 4, p. 339-342, 2003.
0326-2383
http://hdl.handle.net/11449/67436
2-s2.0-0347123113
url http://www.latamjpharm.org/trabajos/22/4/LAJOP_22_4_2_1_BME2CBRX6V.pdf
http://hdl.handle.net/11449/67436
identifier_str_mv Acta Farmaceutica Bonaerense, v. 22, n. 4, p. 339-342, 2003.
0326-2383
2-s2.0-0347123113
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Farmaceutica Bonaerense
0.401
0,152
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 339-342
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129390726348800

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