Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis

Detalhes bibliográficos
Autor(a) principal: Andrade, Gisele Braziliano
Data de Publicação: 2014
Outros Autores: Gomes Barreto, Wanessa Teixeira, Santos, Luciana Ladislau dos, Rios Ribeiro, Laura Raquel, Macedo, Gabriel Carvalho de, Marques de Sousa, Keyla Carstens [UNESP], Andre, Marcos Rogerio [UNESP], Machado, Rosangela Zacarias [UNESP], Herrera, Heitor Miraglia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612014000400509&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/130285
Resumo: Different parasites that commonly occur concomitantly can influence one another, sometimes with unpredictable effects. We evaluated pathological aspects of dogs naturally co-infected with Leishmania infantum and Ehrlichia canis. The health status of the dogs was investigated based on histopathological, hematological and biochemical analyses of 21 animals infected solely with L. infantum and 22 dogs co-infected with L. infantum and E. canis. The skin of both groups showed chronic, predominantly lymphohistioplasmacytic inflammatory reaction. The plasmacytosis in the lymphoid tissues was likely related with the hypergammaglobulinemia detected in all the dogs. The disorganization of extracellular matrix found in the reticular dermis of the inguinal region and ear, characterized by the substitution of thick collagen fibers for thin fibers, was attributed to the degree of inflammatory reaction, irrespective of the presence of parasites. In addition, the histopathological analysis revealed that twice as many dogs in the co-infected group presented Leishmania amastigotes in the ear skin than those infected solely with Leishmania, increasing the possibility of becoming infected through sand fly vectors. Our findings highlight the fact that the health of dogs infected concomitantly with L. infantum and E. canis is severely compromised due to their high levels of total plasma protein, globulins, alkaline phosphatase and creatine kinase, and severe anemia.
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spelling Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canisPatologia de cães naturalmente coinfectados por Leishmania infantum e Ehrlichia canisem Campo Grande, MS, BrasilCanine leishmaniasiscanine ehrlichiosishistopathologyconcomitant infectionsLeishmaniose caninaErliquiose caninaHistopatologiaInfecções concomitantesDifferent parasites that commonly occur concomitantly can influence one another, sometimes with unpredictable effects. We evaluated pathological aspects of dogs naturally co-infected with Leishmania infantum and Ehrlichia canis. The health status of the dogs was investigated based on histopathological, hematological and biochemical analyses of 21 animals infected solely with L. infantum and 22 dogs co-infected with L. infantum and E. canis. The skin of both groups showed chronic, predominantly lymphohistioplasmacytic inflammatory reaction. The plasmacytosis in the lymphoid tissues was likely related with the hypergammaglobulinemia detected in all the dogs. The disorganization of extracellular matrix found in the reticular dermis of the inguinal region and ear, characterized by the substitution of thick collagen fibers for thin fibers, was attributed to the degree of inflammatory reaction, irrespective of the presence of parasites. In addition, the histopathological analysis revealed that twice as many dogs in the co-infected group presented Leishmania amastigotes in the ear skin than those infected solely with Leishmania, increasing the possibility of becoming infected through sand fly vectors. Our findings highlight the fact that the health of dogs infected concomitantly with L. infantum and E. canis is severely compromised due to their high levels of total plasma protein, globulins, alkaline phosphatase and creatine kinase, and severe anemia.A infecção simultânea por parasitas de diferentes espécies pode resultar em alterações imprevisíveis. O presente estudo avaliou a patologia de cães naturalmente coinfectados por Leishmania infantum e Ehrlichia canis. A saúde dos cães foi investigada pelas análises histopatológicas, hematológicas e bioquímicas de 21 cães infectados somente por L. infantum e 22 cães coinfectados por L. infantum e E. canis. Observou-se uma reação inflamatória crônica, predominantemente linfohistioplasmocítica, na pele dos dois grupos. A plasmocitose, encontrada nos tecidos linfóides, provavelmente estava relacionada com a hipergamaglobulinemia observada em todos os cães amostrados. A desorganização da matriz extracelular da derme da região inguinal e da orelha, demonstrada pela substituição das fibras de colágeno espessas por fibras finas, foi relacionada com o grau de reação inflamatória, independente da presença de parasitas. Ainda, observamos duas vezes mais animais do grupo coinfectado apresentando formas amastigotas na pele de orelha pela histopatologia comparado ao número de cães infectados apenas por Leishmania, tornando-os desta forma mais infectivos aos vetores. Nossos resultados ressaltam que a saúde de cães coinfectados estava severamente comprometida devido aos altos níveis de proteína plasmática total, globulinas, fosfatase alcalina, creatina quinase e anemia acentuada.Univ Catolica Dom Bosco, BR-79117900 Campo Grande, MS, BrazilUniv Estadual Paulista, UNESP, Fac Ciencias Agr &Vet, Jaboticabal, SP, BrazilUniv Estadual Paulista, UNESP, Fac Ciencias Agr &Vet, Jaboticabal, SP, BrazilBrazilian Coll Veterinary ParasitologyUniv Catolica Dom BoscoUniversidade Estadual Paulista (Unesp)Andrade, Gisele BrazilianoGomes Barreto, Wanessa TeixeiraSantos, Luciana Ladislau dosRios Ribeiro, Laura RaquelMacedo, Gabriel Carvalho deMarques de Sousa, Keyla Carstens [UNESP]Andre, Marcos Rogerio [UNESP]Machado, Rosangela Zacarias [UNESP]Herrera, Heitor Miraglia2015-11-03T18:06:12Z2015-11-03T18:06:12Z2014-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article509-515application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612014000400509&lng=en&nrm=iso&tlng=enRevista Brasileira De Parasitologia Veterinaria. Sao Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 4, p. 509-515, 2014.1984-2961http://hdl.handle.net/11449/13028510.1590/S1984-29612014081S1984-29612014000400509WOS:000346470000014S1984-29612014000400509.pdf3254990612451836Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira De Parasitologia Veterinaria1.090info:eu-repo/semantics/openAccess2024-06-07T13:02:17Zoai:repositorio.unesp.br:11449/130285Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:31:21.255665Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis
Patologia de cães naturalmente coinfectados por Leishmania infantum e Ehrlichia canisem Campo Grande, MS, Brasil
title Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis
spellingShingle Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis
Andrade, Gisele Braziliano
Canine leishmaniasis
canine ehrlichiosis
histopathology
concomitant infections
Leishmaniose canina
Erliquiose canina
Histopatologia
Infecções concomitantes
title_short Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis
title_full Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis
title_fullStr Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis
title_full_unstemmed Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis
title_sort Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis
author Andrade, Gisele Braziliano
author_facet Andrade, Gisele Braziliano
Gomes Barreto, Wanessa Teixeira
Santos, Luciana Ladislau dos
Rios Ribeiro, Laura Raquel
Macedo, Gabriel Carvalho de
Marques de Sousa, Keyla Carstens [UNESP]
Andre, Marcos Rogerio [UNESP]
Machado, Rosangela Zacarias [UNESP]
Herrera, Heitor Miraglia
author_role author
author2 Gomes Barreto, Wanessa Teixeira
Santos, Luciana Ladislau dos
Rios Ribeiro, Laura Raquel
Macedo, Gabriel Carvalho de
Marques de Sousa, Keyla Carstens [UNESP]
Andre, Marcos Rogerio [UNESP]
Machado, Rosangela Zacarias [UNESP]
Herrera, Heitor Miraglia
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Catolica Dom Bosco
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Andrade, Gisele Braziliano
Gomes Barreto, Wanessa Teixeira
Santos, Luciana Ladislau dos
Rios Ribeiro, Laura Raquel
Macedo, Gabriel Carvalho de
Marques de Sousa, Keyla Carstens [UNESP]
Andre, Marcos Rogerio [UNESP]
Machado, Rosangela Zacarias [UNESP]
Herrera, Heitor Miraglia
dc.subject.por.fl_str_mv Canine leishmaniasis
canine ehrlichiosis
histopathology
concomitant infections
Leishmaniose canina
Erliquiose canina
Histopatologia
Infecções concomitantes
topic Canine leishmaniasis
canine ehrlichiosis
histopathology
concomitant infections
Leishmaniose canina
Erliquiose canina
Histopatologia
Infecções concomitantes
description Different parasites that commonly occur concomitantly can influence one another, sometimes with unpredictable effects. We evaluated pathological aspects of dogs naturally co-infected with Leishmania infantum and Ehrlichia canis. The health status of the dogs was investigated based on histopathological, hematological and biochemical analyses of 21 animals infected solely with L. infantum and 22 dogs co-infected with L. infantum and E. canis. The skin of both groups showed chronic, predominantly lymphohistioplasmacytic inflammatory reaction. The plasmacytosis in the lymphoid tissues was likely related with the hypergammaglobulinemia detected in all the dogs. The disorganization of extracellular matrix found in the reticular dermis of the inguinal region and ear, characterized by the substitution of thick collagen fibers for thin fibers, was attributed to the degree of inflammatory reaction, irrespective of the presence of parasites. In addition, the histopathological analysis revealed that twice as many dogs in the co-infected group presented Leishmania amastigotes in the ear skin than those infected solely with Leishmania, increasing the possibility of becoming infected through sand fly vectors. Our findings highlight the fact that the health of dogs infected concomitantly with L. infantum and E. canis is severely compromised due to their high levels of total plasma protein, globulins, alkaline phosphatase and creatine kinase, and severe anemia.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
2015-11-03T18:06:12Z
2015-11-03T18:06:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612014000400509&lng=en&nrm=iso&tlng=en
Revista Brasileira De Parasitologia Veterinaria. Sao Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 4, p. 509-515, 2014.
1984-2961
http://hdl.handle.net/11449/130285
10.1590/S1984-29612014081
S1984-29612014000400509
WOS:000346470000014
S1984-29612014000400509.pdf
3254990612451836
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612014000400509&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/130285
identifier_str_mv Revista Brasileira De Parasitologia Veterinaria. Sao Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 4, p. 509-515, 2014.
1984-2961
10.1590/S1984-29612014081
S1984-29612014000400509
WOS:000346470000014
S1984-29612014000400509.pdf
3254990612451836
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira De Parasitologia Veterinaria
1.090
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 509-515
application/pdf
dc.publisher.none.fl_str_mv Brazilian Coll Veterinary Parasitology
publisher.none.fl_str_mv Brazilian Coll Veterinary Parasitology
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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