Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp.
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ijbiomac.2021.08.102 http://hdl.handle.net/11449/229397 |
Resumo: | Millions of people are burned worldwide every year and 265,000 of the cases are fatal. The development of burn treatment cannot consist only of the administration of a single drug. Due to the infection risk, antibiotics are used in conjunction with gels and damp bandages. In this work, an inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds. It was produced by the casting method. The infrared spectrum presented no interaction between drug and biopolymer. At the same time, electronic micrographs showed that the SS crystals are inserted on the polymeric dressing surface. Mechanical properties after the drug incorporation were considered suitable for dermal application. About 32.4% of loaded SS was released in 192 h by the dressings that also inhibited the growth of Candida albicans and Candida parapsilosis at 75.0 and 37.5 μg·mL−1, respectively. The curative proved to be biocompatible when applied to fibroblast cells, in addition to enhancing cellular proliferation and, in the hemocompatibility test, no hemolytic effects were observed. The good results in mechanical, antifungal and biological assays, combined with the average bandage cost of $0.10, represent an exciting alternative for treating burn wounds. |
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Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp.AntimicrobialBiomaterialBiopolymerDressingNatural rubber latexSilver sulfadiazineMillions of people are burned worldwide every year and 265,000 of the cases are fatal. The development of burn treatment cannot consist only of the administration of a single drug. Due to the infection risk, antibiotics are used in conjunction with gels and damp bandages. In this work, an inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds. It was produced by the casting method. The infrared spectrum presented no interaction between drug and biopolymer. At the same time, electronic micrographs showed that the SS crystals are inserted on the polymeric dressing surface. Mechanical properties after the drug incorporation were considered suitable for dermal application. About 32.4% of loaded SS was released in 192 h by the dressings that also inhibited the growth of Candida albicans and Candida parapsilosis at 75.0 and 37.5 μg·mL−1, respectively. The curative proved to be biocompatible when applied to fibroblast cells, in addition to enhancing cellular proliferation and, in the hemocompatibility test, no hemolytic effects were observed. The good results in mechanical, antifungal and biological assays, combined with the average bandage cost of $0.10, represent an exciting alternative for treating burn wounds.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Bioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú RoadDepartment of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú RoadDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú RoadArea of Exact Sciences and Engineering University of Caxias do Sul (UCS), 1130 Francisco Getúlio Vargas Street, Caxias do SulTerasaki Institute for Biomedical Innovation (TIBI), 1018 Westwood BlvdBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú RoadDepartment of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú RoadDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú RoadFAPESP: 2011/17411-8FAPESP: 2014/17526-8FAPESP: 2017/18388-6FAPESP: 2017/19603-Universidade Estadual Paulista (UNESP)University of Caxias do Sul (UCS)Terasaki Institute for Biomedical Innovation (TIBI)Tanaka, Jean Lucas [UNESP]Costa-Orlandi, Caroline Barcelos [UNESP]Burd, Betina Sayeg [UNESP]Pegorin, Giovana Sant'Ana [UNESP]da Silva, Thainá Venâncio [UNESP]Guerra, Nayrim BrizuelaMendes-Giannini, Maria José Soares [UNESP]Fusco-Almeida, Ana Marisa [UNESP]Herculano, Rondinelli Donizetti [UNESP]de Barros, Natan Roberto [UNESP]2022-04-29T08:32:15Z2022-04-29T08:32:15Z2021-10-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article597-606http://dx.doi.org/10.1016/j.ijbiomac.2021.08.102International Journal of Biological Macromolecules, v. 189, p. 597-606.1879-00030141-8130http://hdl.handle.net/11449/22939710.1016/j.ijbiomac.2021.08.1022-s2.0-85113446816Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Biological Macromoleculesinfo:eu-repo/semantics/openAccess2024-06-21T15:19:08Zoai:repositorio.unesp.br:11449/229397Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:07.248022Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp. |
title |
Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp. |
spellingShingle |
Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp. Tanaka, Jean Lucas [UNESP] Antimicrobial Biomaterial Biopolymer Dressing Natural rubber latex Silver sulfadiazine |
title_short |
Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp. |
title_full |
Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp. |
title_fullStr |
Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp. |
title_full_unstemmed |
Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp. |
title_sort |
Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp. |
author |
Tanaka, Jean Lucas [UNESP] |
author_facet |
Tanaka, Jean Lucas [UNESP] Costa-Orlandi, Caroline Barcelos [UNESP] Burd, Betina Sayeg [UNESP] Pegorin, Giovana Sant'Ana [UNESP] da Silva, Thainá Venâncio [UNESP] Guerra, Nayrim Brizuela Mendes-Giannini, Maria José Soares [UNESP] Fusco-Almeida, Ana Marisa [UNESP] Herculano, Rondinelli Donizetti [UNESP] de Barros, Natan Roberto [UNESP] |
author_role |
author |
author2 |
Costa-Orlandi, Caroline Barcelos [UNESP] Burd, Betina Sayeg [UNESP] Pegorin, Giovana Sant'Ana [UNESP] da Silva, Thainá Venâncio [UNESP] Guerra, Nayrim Brizuela Mendes-Giannini, Maria José Soares [UNESP] Fusco-Almeida, Ana Marisa [UNESP] Herculano, Rondinelli Donizetti [UNESP] de Barros, Natan Roberto [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) University of Caxias do Sul (UCS) Terasaki Institute for Biomedical Innovation (TIBI) |
dc.contributor.author.fl_str_mv |
Tanaka, Jean Lucas [UNESP] Costa-Orlandi, Caroline Barcelos [UNESP] Burd, Betina Sayeg [UNESP] Pegorin, Giovana Sant'Ana [UNESP] da Silva, Thainá Venâncio [UNESP] Guerra, Nayrim Brizuela Mendes-Giannini, Maria José Soares [UNESP] Fusco-Almeida, Ana Marisa [UNESP] Herculano, Rondinelli Donizetti [UNESP] de Barros, Natan Roberto [UNESP] |
dc.subject.por.fl_str_mv |
Antimicrobial Biomaterial Biopolymer Dressing Natural rubber latex Silver sulfadiazine |
topic |
Antimicrobial Biomaterial Biopolymer Dressing Natural rubber latex Silver sulfadiazine |
description |
Millions of people are burned worldwide every year and 265,000 of the cases are fatal. The development of burn treatment cannot consist only of the administration of a single drug. Due to the infection risk, antibiotics are used in conjunction with gels and damp bandages. In this work, an inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds. It was produced by the casting method. The infrared spectrum presented no interaction between drug and biopolymer. At the same time, electronic micrographs showed that the SS crystals are inserted on the polymeric dressing surface. Mechanical properties after the drug incorporation were considered suitable for dermal application. About 32.4% of loaded SS was released in 192 h by the dressings that also inhibited the growth of Candida albicans and Candida parapsilosis at 75.0 and 37.5 μg·mL−1, respectively. The curative proved to be biocompatible when applied to fibroblast cells, in addition to enhancing cellular proliferation and, in the hemocompatibility test, no hemolytic effects were observed. The good results in mechanical, antifungal and biological assays, combined with the average bandage cost of $0.10, represent an exciting alternative for treating burn wounds. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-31 2022-04-29T08:32:15Z 2022-04-29T08:32:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ijbiomac.2021.08.102 International Journal of Biological Macromolecules, v. 189, p. 597-606. 1879-0003 0141-8130 http://hdl.handle.net/11449/229397 10.1016/j.ijbiomac.2021.08.102 2-s2.0-85113446816 |
url |
http://dx.doi.org/10.1016/j.ijbiomac.2021.08.102 http://hdl.handle.net/11449/229397 |
identifier_str_mv |
International Journal of Biological Macromolecules, v. 189, p. 597-606. 1879-0003 0141-8130 10.1016/j.ijbiomac.2021.08.102 2-s2.0-85113446816 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Biological Macromolecules |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
597-606 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129134249902080 |