Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0103-8478cr20180695 http://hdl.handle.net/11449/190340 |
Resumo: | Cigarette smoke in large centers is one of the most important causes of chronic inflammatory diseases in public health and is associated with a decrease in bone mass, consolidation process, and bone remodeling. Due to their ability to improve intestinal absorption and compete with pathogenic microorganisms, dietary supplementation with functional foods may contribute to improvement in bone quality. Therefore, the objective of this study was to evaluate the effects of functional, probiotic, prebiotic, or symbiotic food supplementation on mineral composition, histomorphometry, and bone biomechanical properties of rats in the growth phase, chronically exposed to cigarette smoke (T).Sixty-four young male rats were randomly assigned to eight groups (n=8): control (C) [standard diet (SD)]; probiotic (Pro) [SD + probiotic (Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum) (2–5 109 UFC each)]; prebiotic (Pre) [SD+ prebiotic (mannan oligosaccharide)]; symbiotic (Sym) (SD + probiotic + prebiotic); control smoking (SC) [(SD + exposure protocol to passive smoking (PS)]; probiotic smoking (ProS) (SD + probiotic + PS); prebiotic smoking (PreS) (SD + prebiotic + PS), and symbiotic smoking (SymS)(SD + prebiotic + probiotic + PS). The animals were euthanized after 189 days of the experimental protocol. Results showed that supplementation with probiotics, prebiotics, and symbiotics significantly improved (P<0.05) the parameters: P, Ca, Mg, BMD, BMC, strength, resilience, and size of area of the femoral diaphysis of the animals chronically exposed or not cigarette smoke. We concluded that functional food supplementation improved the bone health of rats chronically exposed or not to cigarette smoke. |
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Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical studyComposição mineral, histomorfometria e propriedades biomecânicas óssea são melhoradas com a suplementação de probióticos, prebióticos e simbióticos em ratos expostos cronicamente ao tabagismo passivo: Estudo pré-clínico randomizadoBone massCigarette smokeFemurFunctional foodsNutritionCigarette smoke in large centers is one of the most important causes of chronic inflammatory diseases in public health and is associated with a decrease in bone mass, consolidation process, and bone remodeling. Due to their ability to improve intestinal absorption and compete with pathogenic microorganisms, dietary supplementation with functional foods may contribute to improvement in bone quality. Therefore, the objective of this study was to evaluate the effects of functional, probiotic, prebiotic, or symbiotic food supplementation on mineral composition, histomorphometry, and bone biomechanical properties of rats in the growth phase, chronically exposed to cigarette smoke (T).Sixty-four young male rats were randomly assigned to eight groups (n=8): control (C) [standard diet (SD)]; probiotic (Pro) [SD + probiotic (Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum) (2–5 109 UFC each)]; prebiotic (Pre) [SD+ prebiotic (mannan oligosaccharide)]; symbiotic (Sym) (SD + probiotic + prebiotic); control smoking (SC) [(SD + exposure protocol to passive smoking (PS)]; probiotic smoking (ProS) (SD + probiotic + PS); prebiotic smoking (PreS) (SD + prebiotic + PS), and symbiotic smoking (SymS)(SD + prebiotic + probiotic + PS). The animals were euthanized after 189 days of the experimental protocol. Results showed that supplementation with probiotics, prebiotics, and symbiotics significantly improved (P<0.05) the parameters: P, Ca, Mg, BMD, BMC, strength, resilience, and size of area of the femoral diaphysis of the animals chronically exposed or not cigarette smoke. We concluded that functional food supplementation improved the bone health of rats chronically exposed or not to cigarette smoke.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Departamento de Ciências Funcionais Faculdade de Medicina Universidade do Oeste Paulista (UNOESTE)Departamento de Microbiologia Universidade do Oeste Paulista (UNOESTE)Departamento de Patologia Universidade de Santo Amaro (UNISA)Faculdade de Medicina Veterinária (FMVA) Universidade Estadual Paulista (UNESP)Faculdade de Medicina Veterinária (FMVA) Universidade Estadual Paulista (UNESP)Universidade do Oeste Paulista (UNOESTE)Universidade de Santo Amaro (UNISA)Universidade Estadual Paulista (Unesp)Louzada, Mario Jefferson Quirino [UNESP]Bremer-Neto, HermannTribst, Marcelo FernandesMagalhães, Leticia RochaSilva, Ricardo AugustoCaetano, Heliard Rodrigues Dos Santosde Oliveira, Weber Gutemberg AlvesRufino, Marcos NatalKeller, RogériaSanches, Osimar de Carvalho2019-10-06T17:09:58Z2019-10-06T17:09:58Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1590/0103-8478cr20180695Ciencia Rural, v. 49, n. 5, 2019.1678-45960103-8478http://hdl.handle.net/11449/19034010.1590/0103-8478cr20180695S0103-847820190005005512-s2.0-85065878390S0103-84782019000500551.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCiencia Ruralinfo:eu-repo/semantics/openAccess2024-09-04T19:15:38Zoai:repositorio.unesp.br:11449/190340Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:15:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study Composição mineral, histomorfometria e propriedades biomecânicas óssea são melhoradas com a suplementação de probióticos, prebióticos e simbióticos em ratos expostos cronicamente ao tabagismo passivo: Estudo pré-clínico randomizado |
title |
Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study |
spellingShingle |
Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study Louzada, Mario Jefferson Quirino [UNESP] Bone mass Cigarette smoke Femur Functional foods Nutrition |
title_short |
Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study |
title_full |
Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study |
title_fullStr |
Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study |
title_full_unstemmed |
Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study |
title_sort |
Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study |
author |
Louzada, Mario Jefferson Quirino [UNESP] |
author_facet |
Louzada, Mario Jefferson Quirino [UNESP] Bremer-Neto, Hermann Tribst, Marcelo Fernandes Magalhães, Leticia Rocha Silva, Ricardo Augusto Caetano, Heliard Rodrigues Dos Santos de Oliveira, Weber Gutemberg Alves Rufino, Marcos Natal Keller, Rogéria Sanches, Osimar de Carvalho |
author_role |
author |
author2 |
Bremer-Neto, Hermann Tribst, Marcelo Fernandes Magalhães, Leticia Rocha Silva, Ricardo Augusto Caetano, Heliard Rodrigues Dos Santos de Oliveira, Weber Gutemberg Alves Rufino, Marcos Natal Keller, Rogéria Sanches, Osimar de Carvalho |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Oeste Paulista (UNOESTE) Universidade de Santo Amaro (UNISA) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Louzada, Mario Jefferson Quirino [UNESP] Bremer-Neto, Hermann Tribst, Marcelo Fernandes Magalhães, Leticia Rocha Silva, Ricardo Augusto Caetano, Heliard Rodrigues Dos Santos de Oliveira, Weber Gutemberg Alves Rufino, Marcos Natal Keller, Rogéria Sanches, Osimar de Carvalho |
dc.subject.por.fl_str_mv |
Bone mass Cigarette smoke Femur Functional foods Nutrition |
topic |
Bone mass Cigarette smoke Femur Functional foods Nutrition |
description |
Cigarette smoke in large centers is one of the most important causes of chronic inflammatory diseases in public health and is associated with a decrease in bone mass, consolidation process, and bone remodeling. Due to their ability to improve intestinal absorption and compete with pathogenic microorganisms, dietary supplementation with functional foods may contribute to improvement in bone quality. Therefore, the objective of this study was to evaluate the effects of functional, probiotic, prebiotic, or symbiotic food supplementation on mineral composition, histomorphometry, and bone biomechanical properties of rats in the growth phase, chronically exposed to cigarette smoke (T).Sixty-four young male rats were randomly assigned to eight groups (n=8): control (C) [standard diet (SD)]; probiotic (Pro) [SD + probiotic (Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum) (2–5 109 UFC each)]; prebiotic (Pre) [SD+ prebiotic (mannan oligosaccharide)]; symbiotic (Sym) (SD + probiotic + prebiotic); control smoking (SC) [(SD + exposure protocol to passive smoking (PS)]; probiotic smoking (ProS) (SD + probiotic + PS); prebiotic smoking (PreS) (SD + prebiotic + PS), and symbiotic smoking (SymS)(SD + prebiotic + probiotic + PS). The animals were euthanized after 189 days of the experimental protocol. Results showed that supplementation with probiotics, prebiotics, and symbiotics significantly improved (P<0.05) the parameters: P, Ca, Mg, BMD, BMC, strength, resilience, and size of area of the femoral diaphysis of the animals chronically exposed or not cigarette smoke. We concluded that functional food supplementation improved the bone health of rats chronically exposed or not to cigarette smoke. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:09:58Z 2019-10-06T17:09:58Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0103-8478cr20180695 Ciencia Rural, v. 49, n. 5, 2019. 1678-4596 0103-8478 http://hdl.handle.net/11449/190340 10.1590/0103-8478cr20180695 S0103-84782019000500551 2-s2.0-85065878390 S0103-84782019000500551.pdf |
url |
http://dx.doi.org/10.1590/0103-8478cr20180695 http://hdl.handle.net/11449/190340 |
identifier_str_mv |
Ciencia Rural, v. 49, n. 5, 2019. 1678-4596 0103-8478 10.1590/0103-8478cr20180695 S0103-84782019000500551 2-s2.0-85065878390 S0103-84782019000500551.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ciencia Rural |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021386948706304 |