Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study

Detalhes bibliográficos
Autor(a) principal: Louzada, Mario Jefferson Quirino [UNESP]
Data de Publicação: 2019
Outros Autores: Bremer-Neto, Hermann, Tribst, Marcelo Fernandes, Magalhães, Leticia Rocha, Silva, Ricardo Augusto, Caetano, Heliard Rodrigues Dos Santos, de Oliveira, Weber Gutemberg Alves, Rufino, Marcos Natal, Keller, Rogéria, Sanches, Osimar de Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/0103-8478cr20180695
http://hdl.handle.net/11449/190340
Resumo: Cigarette smoke in large centers is one of the most important causes of chronic inflammatory diseases in public health and is associated with a decrease in bone mass, consolidation process, and bone remodeling. Due to their ability to improve intestinal absorption and compete with pathogenic microorganisms, dietary supplementation with functional foods may contribute to improvement in bone quality. Therefore, the objective of this study was to evaluate the effects of functional, probiotic, prebiotic, or symbiotic food supplementation on mineral composition, histomorphometry, and bone biomechanical properties of rats in the growth phase, chronically exposed to cigarette smoke (T).Sixty-four young male rats were randomly assigned to eight groups (n=8): control (C) [standard diet (SD)]; probiotic (Pro) [SD + probiotic (Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum) (2–5 109 UFC each)]; prebiotic (Pre) [SD+ prebiotic (mannan oligosaccharide)]; symbiotic (Sym) (SD + probiotic + prebiotic); control smoking (SC) [(SD + exposure protocol to passive smoking (PS)]; probiotic smoking (ProS) (SD + probiotic + PS); prebiotic smoking (PreS) (SD + prebiotic + PS), and symbiotic smoking (SymS)(SD + prebiotic + probiotic + PS). The animals were euthanized after 189 days of the experimental protocol. Results showed that supplementation with probiotics, prebiotics, and symbiotics significantly improved (P<0.05) the parameters: P, Ca, Mg, BMD, BMC, strength, resilience, and size of area of the femoral diaphysis of the animals chronically exposed or not cigarette smoke. We concluded that functional food supplementation improved the bone health of rats chronically exposed or not to cigarette smoke.
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spelling Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical studyComposição mineral, histomorfometria e propriedades biomecânicas óssea são melhoradas com a suplementação de probióticos, prebióticos e simbióticos em ratos expostos cronicamente ao tabagismo passivo: Estudo pré-clínico randomizadoBone massCigarette smokeFemurFunctional foodsNutritionCigarette smoke in large centers is one of the most important causes of chronic inflammatory diseases in public health and is associated with a decrease in bone mass, consolidation process, and bone remodeling. Due to their ability to improve intestinal absorption and compete with pathogenic microorganisms, dietary supplementation with functional foods may contribute to improvement in bone quality. Therefore, the objective of this study was to evaluate the effects of functional, probiotic, prebiotic, or symbiotic food supplementation on mineral composition, histomorphometry, and bone biomechanical properties of rats in the growth phase, chronically exposed to cigarette smoke (T).Sixty-four young male rats were randomly assigned to eight groups (n=8): control (C) [standard diet (SD)]; probiotic (Pro) [SD + probiotic (Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum) (2–5 109 UFC each)]; prebiotic (Pre) [SD+ prebiotic (mannan oligosaccharide)]; symbiotic (Sym) (SD + probiotic + prebiotic); control smoking (SC) [(SD + exposure protocol to passive smoking (PS)]; probiotic smoking (ProS) (SD + probiotic + PS); prebiotic smoking (PreS) (SD + prebiotic + PS), and symbiotic smoking (SymS)(SD + prebiotic + probiotic + PS). The animals were euthanized after 189 days of the experimental protocol. Results showed that supplementation with probiotics, prebiotics, and symbiotics significantly improved (P<0.05) the parameters: P, Ca, Mg, BMD, BMC, strength, resilience, and size of area of the femoral diaphysis of the animals chronically exposed or not cigarette smoke. We concluded that functional food supplementation improved the bone health of rats chronically exposed or not to cigarette smoke.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Departamento de Ciências Funcionais Faculdade de Medicina Universidade do Oeste Paulista (UNOESTE)Departamento de Microbiologia Universidade do Oeste Paulista (UNOESTE)Departamento de Patologia Universidade de Santo Amaro (UNISA)Faculdade de Medicina Veterinária (FMVA) Universidade Estadual Paulista (UNESP)Faculdade de Medicina Veterinária (FMVA) Universidade Estadual Paulista (UNESP)Universidade do Oeste Paulista (UNOESTE)Universidade de Santo Amaro (UNISA)Universidade Estadual Paulista (Unesp)Louzada, Mario Jefferson Quirino [UNESP]Bremer-Neto, HermannTribst, Marcelo FernandesMagalhães, Leticia RochaSilva, Ricardo AugustoCaetano, Heliard Rodrigues Dos Santosde Oliveira, Weber Gutemberg AlvesRufino, Marcos NatalKeller, RogériaSanches, Osimar de Carvalho2019-10-06T17:09:58Z2019-10-06T17:09:58Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1590/0103-8478cr20180695Ciencia Rural, v. 49, n. 5, 2019.1678-45960103-8478http://hdl.handle.net/11449/19034010.1590/0103-8478cr20180695S0103-847820190005005512-s2.0-85065878390S0103-84782019000500551.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCiencia Ruralinfo:eu-repo/semantics/openAccess2024-09-04T19:15:38Zoai:repositorio.unesp.br:11449/190340Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:15:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
Composição mineral, histomorfometria e propriedades biomecânicas óssea são melhoradas com a suplementação de probióticos, prebióticos e simbióticos em ratos expostos cronicamente ao tabagismo passivo: Estudo pré-clínico randomizado
title Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
spellingShingle Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
Louzada, Mario Jefferson Quirino [UNESP]
Bone mass
Cigarette smoke
Femur
Functional foods
Nutrition
title_short Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
title_full Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
title_fullStr Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
title_full_unstemmed Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
title_sort Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passive smoking: A randomized pre-clinical study
author Louzada, Mario Jefferson Quirino [UNESP]
author_facet Louzada, Mario Jefferson Quirino [UNESP]
Bremer-Neto, Hermann
Tribst, Marcelo Fernandes
Magalhães, Leticia Rocha
Silva, Ricardo Augusto
Caetano, Heliard Rodrigues Dos Santos
de Oliveira, Weber Gutemberg Alves
Rufino, Marcos Natal
Keller, Rogéria
Sanches, Osimar de Carvalho
author_role author
author2 Bremer-Neto, Hermann
Tribst, Marcelo Fernandes
Magalhães, Leticia Rocha
Silva, Ricardo Augusto
Caetano, Heliard Rodrigues Dos Santos
de Oliveira, Weber Gutemberg Alves
Rufino, Marcos Natal
Keller, Rogéria
Sanches, Osimar de Carvalho
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Oeste Paulista (UNOESTE)
Universidade de Santo Amaro (UNISA)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Louzada, Mario Jefferson Quirino [UNESP]
Bremer-Neto, Hermann
Tribst, Marcelo Fernandes
Magalhães, Leticia Rocha
Silva, Ricardo Augusto
Caetano, Heliard Rodrigues Dos Santos
de Oliveira, Weber Gutemberg Alves
Rufino, Marcos Natal
Keller, Rogéria
Sanches, Osimar de Carvalho
dc.subject.por.fl_str_mv Bone mass
Cigarette smoke
Femur
Functional foods
Nutrition
topic Bone mass
Cigarette smoke
Femur
Functional foods
Nutrition
description Cigarette smoke in large centers is one of the most important causes of chronic inflammatory diseases in public health and is associated with a decrease in bone mass, consolidation process, and bone remodeling. Due to their ability to improve intestinal absorption and compete with pathogenic microorganisms, dietary supplementation with functional foods may contribute to improvement in bone quality. Therefore, the objective of this study was to evaluate the effects of functional, probiotic, prebiotic, or symbiotic food supplementation on mineral composition, histomorphometry, and bone biomechanical properties of rats in the growth phase, chronically exposed to cigarette smoke (T).Sixty-four young male rats were randomly assigned to eight groups (n=8): control (C) [standard diet (SD)]; probiotic (Pro) [SD + probiotic (Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum) (2–5 109 UFC each)]; prebiotic (Pre) [SD+ prebiotic (mannan oligosaccharide)]; symbiotic (Sym) (SD + probiotic + prebiotic); control smoking (SC) [(SD + exposure protocol to passive smoking (PS)]; probiotic smoking (ProS) (SD + probiotic + PS); prebiotic smoking (PreS) (SD + prebiotic + PS), and symbiotic smoking (SymS)(SD + prebiotic + probiotic + PS). The animals were euthanized after 189 days of the experimental protocol. Results showed that supplementation with probiotics, prebiotics, and symbiotics significantly improved (P<0.05) the parameters: P, Ca, Mg, BMD, BMC, strength, resilience, and size of area of the femoral diaphysis of the animals chronically exposed or not cigarette smoke. We concluded that functional food supplementation improved the bone health of rats chronically exposed or not to cigarette smoke.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T17:09:58Z
2019-10-06T17:09:58Z
2019-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0103-8478cr20180695
Ciencia Rural, v. 49, n. 5, 2019.
1678-4596
0103-8478
http://hdl.handle.net/11449/190340
10.1590/0103-8478cr20180695
S0103-84782019000500551
2-s2.0-85065878390
S0103-84782019000500551.pdf
url http://dx.doi.org/10.1590/0103-8478cr20180695
http://hdl.handle.net/11449/190340
identifier_str_mv Ciencia Rural, v. 49, n. 5, 2019.
1678-4596
0103-8478
10.1590/0103-8478cr20180695
S0103-84782019000500551
2-s2.0-85065878390
S0103-84782019000500551.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ciencia Rural
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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