Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters

Detalhes bibliográficos
Autor(a) principal: Picão, Bruno W. [UNESP]
Data de Publicação: 2023
Outros Autores: Gonçalves, Daniele O. [UNESP], Ribeiro, Renata M. M. G. P., Esperança, Mateus N., Peixoto, Guilherme [UNESP], Cerri, Marcel O. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s00449-023-02853-w
http://hdl.handle.net/11449/246852
Resumo: Bioreactors can perform biochemical conversions mediated by biocatalysts, such as enzymes, animal cells, plants, and microorganisms. Among several existing models, airlift bioreactors are devices with the low shear environment and good mass transfer with low energy consumption, employed in several biochemical processes. The fluid flow is enabled through air injection by the sparger located at the bioreactor base. Despite its simple geometry compared with the conventional bioreactors, airlift performance can be optimized via geometrical modifications. Therefore, the objective of this work was to evaluate the effects of the addition of helical flow promoters, positioned in the riser and/or downcomer regions of an airlift of concentric tubes measuring the volumetric oxygen coefficient (kLa) and gas holdup. The results obtained by varying the gas flow rate from 1.0 to 4.0 vvm allowed the system evaluation of oxygen transfer and gas holdup. The inclusion of helical flow promoters increased the kLa, reaching up to 23% in oxygen transfer compared to tests without helicoids and up to 14% increase in the gas holdup. The inclusion of helical flow promotors was beneficial for all gas flow rates. Thus, including these flow promoters is an effective strategy to increase the oxygen transfer rate for bioprocess optimization.
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spelling Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promotersAirlift bioreactorGas holdupHelical flow promotersOxygen transferBioreactors can perform biochemical conversions mediated by biocatalysts, such as enzymes, animal cells, plants, and microorganisms. Among several existing models, airlift bioreactors are devices with the low shear environment and good mass transfer with low energy consumption, employed in several biochemical processes. The fluid flow is enabled through air injection by the sparger located at the bioreactor base. Despite its simple geometry compared with the conventional bioreactors, airlift performance can be optimized via geometrical modifications. Therefore, the objective of this work was to evaluate the effects of the addition of helical flow promoters, positioned in the riser and/or downcomer regions of an airlift of concentric tubes measuring the volumetric oxygen coefficient (kLa) and gas holdup. The results obtained by varying the gas flow rate from 1.0 to 4.0 vvm allowed the system evaluation of oxygen transfer and gas holdup. The inclusion of helical flow promoters increased the kLa, reaching up to 23% in oxygen transfer compared to tests without helicoids and up to 14% increase in the gas holdup. The inclusion of helical flow promotors was beneficial for all gas flow rates. Thus, including these flow promoters is an effective strategy to increase the oxygen transfer rate for bioprocess optimization.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Bioprocesses Engineering and Biotechnology Faculty of Pharmaceutical Sciences University Estadual Paulista “Júlio de Mesquita Filho”, SPSchool of Chemical Engineering Department of Materials and Engineering Bioprocesses State University of Campinas, SPFederal Institute of Education Science and Technology of São Paulo, Campus Capivari, SPDepartment of Bioprocesses Engineering and Biotechnology Faculty of Pharmaceutical Sciences University Estadual Paulista “Júlio de Mesquita Filho”, SPCAPES: 001FAPESP: 20/08699-7CAPES: 88887.627186/2021-00Universidade Estadual Paulista (UNESP)Universidade Estadual de Campinas (UNICAMP)Science and Technology of São PauloPicão, Bruno W. [UNESP]Gonçalves, Daniele O. [UNESP]Ribeiro, Renata M. M. G. P.Esperança, Mateus N.Peixoto, Guilherme [UNESP]Cerri, Marcel O. [UNESP]2023-07-29T12:52:14Z2023-07-29T12:52:14Z2023-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article681-692http://dx.doi.org/10.1007/s00449-023-02853-wBioprocess and Biosystems Engineering, v. 46, n. 5, p. 681-692, 2023.1615-76051615-7591http://hdl.handle.net/11449/24685210.1007/s00449-023-02853-w2-s2.0-85148365514Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioprocess and Biosystems Engineeringinfo:eu-repo/semantics/openAccess2023-07-29T12:52:14Zoai:repositorio.unesp.br:11449/246852Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:47:30.891381Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
title Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
spellingShingle Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
Picão, Bruno W. [UNESP]
Airlift bioreactor
Gas holdup
Helical flow promoters
Oxygen transfer
title_short Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
title_full Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
title_fullStr Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
title_full_unstemmed Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
title_sort Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
author Picão, Bruno W. [UNESP]
author_facet Picão, Bruno W. [UNESP]
Gonçalves, Daniele O. [UNESP]
Ribeiro, Renata M. M. G. P.
Esperança, Mateus N.
Peixoto, Guilherme [UNESP]
Cerri, Marcel O. [UNESP]
author_role author
author2 Gonçalves, Daniele O. [UNESP]
Ribeiro, Renata M. M. G. P.
Esperança, Mateus N.
Peixoto, Guilherme [UNESP]
Cerri, Marcel O. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade Estadual de Campinas (UNICAMP)
Science and Technology of São Paulo
dc.contributor.author.fl_str_mv Picão, Bruno W. [UNESP]
Gonçalves, Daniele O. [UNESP]
Ribeiro, Renata M. M. G. P.
Esperança, Mateus N.
Peixoto, Guilherme [UNESP]
Cerri, Marcel O. [UNESP]
dc.subject.por.fl_str_mv Airlift bioreactor
Gas holdup
Helical flow promoters
Oxygen transfer
topic Airlift bioreactor
Gas holdup
Helical flow promoters
Oxygen transfer
description Bioreactors can perform biochemical conversions mediated by biocatalysts, such as enzymes, animal cells, plants, and microorganisms. Among several existing models, airlift bioreactors are devices with the low shear environment and good mass transfer with low energy consumption, employed in several biochemical processes. The fluid flow is enabled through air injection by the sparger located at the bioreactor base. Despite its simple geometry compared with the conventional bioreactors, airlift performance can be optimized via geometrical modifications. Therefore, the objective of this work was to evaluate the effects of the addition of helical flow promoters, positioned in the riser and/or downcomer regions of an airlift of concentric tubes measuring the volumetric oxygen coefficient (kLa) and gas holdup. The results obtained by varying the gas flow rate from 1.0 to 4.0 vvm allowed the system evaluation of oxygen transfer and gas holdup. The inclusion of helical flow promoters increased the kLa, reaching up to 23% in oxygen transfer compared to tests without helicoids and up to 14% increase in the gas holdup. The inclusion of helical flow promotors was beneficial for all gas flow rates. Thus, including these flow promoters is an effective strategy to increase the oxygen transfer rate for bioprocess optimization.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T12:52:14Z
2023-07-29T12:52:14Z
2023-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s00449-023-02853-w
Bioprocess and Biosystems Engineering, v. 46, n. 5, p. 681-692, 2023.
1615-7605
1615-7591
http://hdl.handle.net/11449/246852
10.1007/s00449-023-02853-w
2-s2.0-85148365514
url http://dx.doi.org/10.1007/s00449-023-02853-w
http://hdl.handle.net/11449/246852
identifier_str_mv Bioprocess and Biosystems Engineering, v. 46, n. 5, p. 681-692, 2023.
1615-7605
1615-7591
10.1007/s00449-023-02853-w
2-s2.0-85148365514
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bioprocess and Biosystems Engineering
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 681-692
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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