Linking genetic and environmental factors in amphibian disease risk
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://onlinelibrary.wiley.com/doi/10.1111/eva.12264/full http://hdl.handle.net/11449/128775 |
Resumo: | A central question in evolutionary biology is how interactions between organisms and the environment shape genetic differentiation. The pathogen Batrachochytrium dendrobatidis (Bd) has caused variable population declines in the lowland leopard frog (Lithobates yavapaiensis); thus, disease has potentially shaped, or been shaped by, host genetic diversity. Environmental factors can also influence both amphibian immunity and Bd virulence, confounding our ability to assess the genetic effects on disease dynamics. Here, we used genetics, pathogen dynamics, and environmental data to characterize L.yavapaiensis populations, estimate migration, and determine relative contributions of genetic and environmental factors in predicting Bd dynamics. We found that the two uninfected populations belonged to a single genetic deme, whereas each infected population was genetically unique. We detected an outlier locus that deviated from neutral expectations and was significantly correlated with mortality within populations. Across populations, only environmental variables predicted infection intensity, whereas environment and genetics predicted infection prevalence, and genetic diversity alone predicted mortality. At one locality with geothermally elevated water temperatures, migration estimates revealed source-sink dynamics that have likely prevented local adaptation. We conclude that integrating genetic and environmental variation among populations provides a better understanding of Bd spatial epidemiology, generating more effective conservation management strategies for mitigating amphibian declines. |
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Linking genetic and environmental factors in amphibian disease riskAmphibianConservation geneticsDisease biologyHost-parasite interactionsPopulation geneticsA central question in evolutionary biology is how interactions between organisms and the environment shape genetic differentiation. The pathogen Batrachochytrium dendrobatidis (Bd) has caused variable population declines in the lowland leopard frog (Lithobates yavapaiensis); thus, disease has potentially shaped, or been shaped by, host genetic diversity. Environmental factors can also influence both amphibian immunity and Bd virulence, confounding our ability to assess the genetic effects on disease dynamics. Here, we used genetics, pathogen dynamics, and environmental data to characterize L.yavapaiensis populations, estimate migration, and determine relative contributions of genetic and environmental factors in predicting Bd dynamics. We found that the two uninfected populations belonged to a single genetic deme, whereas each infected population was genetically unique. We detected an outlier locus that deviated from neutral expectations and was significantly correlated with mortality within populations. Across populations, only environmental variables predicted infection intensity, whereas environment and genetics predicted infection prevalence, and genetic diversity alone predicted mortality. At one locality with geothermally elevated water temperatures, migration estimates revealed source-sink dynamics that have likely prevented local adaptation. We conclude that integrating genetic and environmental variation among populations provides a better understanding of Bd spatial epidemiology, generating more effective conservation management strategies for mitigating amphibian declines.National Science Foundation (NSF)Doctoral Dissertation Improvement GrantPopulation Evolutionary Processes grantNational Geographic SocietyDepartment of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, USADepartment of Biology, University of Central Florida, Orlando, FL 32816, USADepartment of Zoology, State University of Sao Paulo, Rio Claro, BrazilDoctoral Dissertation Improvement Grant: DEB-0909013Population Evolutionary Processes grant: DEB-0815315Wiley-BlackwellCornell UniversityUniversity of Central FloridaUniversidade Estadual Paulista (Unesp)Savage, Anna E.Becker, Carlos G. [UNESP]Zamudio, Kelly R.2015-10-21T13:13:24Z2015-10-21T13:13:24Z2015-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article560-572application/pdfhttp://onlinelibrary.wiley.com/doi/10.1111/eva.12264/fullEvolutionary Applications. Hoboken: Wiley-blackwell, v. 8, n. 6, p. 560-572, 2015.1752-4571http://hdl.handle.net/11449/12877510.1111/eva.12264WOS:000356682200005WOS000356682200005.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvolutionary Applications4.6942,676info:eu-repo/semantics/openAccess2024-01-08T06:23:27Zoai:repositorio.unesp.br:11449/128775Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:24:40.282212Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Linking genetic and environmental factors in amphibian disease risk |
title |
Linking genetic and environmental factors in amphibian disease risk |
spellingShingle |
Linking genetic and environmental factors in amphibian disease risk Savage, Anna E. Amphibian Conservation genetics Disease biology Host-parasite interactions Population genetics |
title_short |
Linking genetic and environmental factors in amphibian disease risk |
title_full |
Linking genetic and environmental factors in amphibian disease risk |
title_fullStr |
Linking genetic and environmental factors in amphibian disease risk |
title_full_unstemmed |
Linking genetic and environmental factors in amphibian disease risk |
title_sort |
Linking genetic and environmental factors in amphibian disease risk |
author |
Savage, Anna E. |
author_facet |
Savage, Anna E. Becker, Carlos G. [UNESP] Zamudio, Kelly R. |
author_role |
author |
author2 |
Becker, Carlos G. [UNESP] Zamudio, Kelly R. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Cornell University University of Central Florida Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Savage, Anna E. Becker, Carlos G. [UNESP] Zamudio, Kelly R. |
dc.subject.por.fl_str_mv |
Amphibian Conservation genetics Disease biology Host-parasite interactions Population genetics |
topic |
Amphibian Conservation genetics Disease biology Host-parasite interactions Population genetics |
description |
A central question in evolutionary biology is how interactions between organisms and the environment shape genetic differentiation. The pathogen Batrachochytrium dendrobatidis (Bd) has caused variable population declines in the lowland leopard frog (Lithobates yavapaiensis); thus, disease has potentially shaped, or been shaped by, host genetic diversity. Environmental factors can also influence both amphibian immunity and Bd virulence, confounding our ability to assess the genetic effects on disease dynamics. Here, we used genetics, pathogen dynamics, and environmental data to characterize L.yavapaiensis populations, estimate migration, and determine relative contributions of genetic and environmental factors in predicting Bd dynamics. We found that the two uninfected populations belonged to a single genetic deme, whereas each infected population was genetically unique. We detected an outlier locus that deviated from neutral expectations and was significantly correlated with mortality within populations. Across populations, only environmental variables predicted infection intensity, whereas environment and genetics predicted infection prevalence, and genetic diversity alone predicted mortality. At one locality with geothermally elevated water temperatures, migration estimates revealed source-sink dynamics that have likely prevented local adaptation. We conclude that integrating genetic and environmental variation among populations provides a better understanding of Bd spatial epidemiology, generating more effective conservation management strategies for mitigating amphibian declines. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:13:24Z 2015-10-21T13:13:24Z 2015-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://onlinelibrary.wiley.com/doi/10.1111/eva.12264/full Evolutionary Applications. Hoboken: Wiley-blackwell, v. 8, n. 6, p. 560-572, 2015. 1752-4571 http://hdl.handle.net/11449/128775 10.1111/eva.12264 WOS:000356682200005 WOS000356682200005.pdf |
url |
http://onlinelibrary.wiley.com/doi/10.1111/eva.12264/full http://hdl.handle.net/11449/128775 |
identifier_str_mv |
Evolutionary Applications. Hoboken: Wiley-blackwell, v. 8, n. 6, p. 560-572, 2015. 1752-4571 10.1111/eva.12264 WOS:000356682200005 WOS000356682200005.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evolutionary Applications 4.694 2,676 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
560-572 application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129424810311680 |