Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals

Detalhes bibliográficos
Autor(a) principal: Franzé, J. A.
Data de Publicação: 2017
Outros Autores: Carvalho, T. F., Gaglieri, C. [UNESP], Caires, F. J. [UNESP], Bannach, G. [UNESP], Castro, R. C., Treu-Filho, O. [UNESP], Ionashiro, M. [UNESP], Mendes, R. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10973-016-6030-5
http://hdl.handle.net/11449/178513
Resumo: Complexes of meloxicam with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) were prepared by aqueous precipitation. The compounds were characterized by means of X-ray powder diffractometry, infrared spectroscopy, theoretical calculation, elemental analysis (CNH), differential scanning calorimetry, simultaneous TG/DTG-DTA and evolved gas analysis (EGA). The results obtained from the TG/DTG-DTA curves and elemental analysis made it possible to establish the general formula of these compounds as [M(Hmel)2(H2O)2]nH2O, where M = Mn(II), Co(II), Ni(II); Cu(II) and Zn(II); Hmel = meloxicam and n = 2 (Mn, Co, Ni, Zn) and 1 (Cu). The simultaneous TG/DTG-DTA data provided previously unreported information about the thermal stability and thermal decomposition of these compounds in dynamic air and nitrogen atmospheres. The EGA showed the remarkable influence of the atmosphere in the thermal decomposition mechanism of these complexes, and it was also possible to identify the main gaseous products of thermal degradation. The lowest energy model structure of the Mn(II), Ni(II) and Zin(II) complexes has been proposed by using the density functional theory at the B3LYP/6-311++G(d) level of theory, and the theoretical spectra were calculated. The antibacterial activity of the compounds was also evaluated in relation to S. aureus by the diffusion method in agar, and the compounds showed little activity. The anti-inflammatory activity of the meloxicam–copper complex was also evaluated in vivo by the rat paw edema method. The compound showed no anti-inflammatory activity, which may have been due to loss of intrinsic activity or poor oral absorption caused by low solubility.
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spelling Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metalsBioactivityDFTMeloxicamThermal behaviorTransition metalsComplexes of meloxicam with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) were prepared by aqueous precipitation. The compounds were characterized by means of X-ray powder diffractometry, infrared spectroscopy, theoretical calculation, elemental analysis (CNH), differential scanning calorimetry, simultaneous TG/DTG-DTA and evolved gas analysis (EGA). The results obtained from the TG/DTG-DTA curves and elemental analysis made it possible to establish the general formula of these compounds as [M(Hmel)2(H2O)2]nH2O, where M = Mn(II), Co(II), Ni(II); Cu(II) and Zn(II); Hmel = meloxicam and n = 2 (Mn, Co, Ni, Zn) and 1 (Cu). The simultaneous TG/DTG-DTA data provided previously unreported information about the thermal stability and thermal decomposition of these compounds in dynamic air and nitrogen atmospheres. The EGA showed the remarkable influence of the atmosphere in the thermal decomposition mechanism of these complexes, and it was also possible to identify the main gaseous products of thermal degradation. The lowest energy model structure of the Mn(II), Ni(II) and Zin(II) complexes has been proposed by using the density functional theory at the B3LYP/6-311++G(d) level of theory, and the theoretical spectra were calculated. The antibacterial activity of the compounds was also evaluated in relation to S. aureus by the diffusion method in agar, and the compounds showed little activity. The anti-inflammatory activity of the meloxicam–copper complex was also evaluated in vivo by the rat paw edema method. The compound showed no anti-inflammatory activity, which may have been due to loss of intrinsic activity or poor oral absorption caused by low solubility.Instituto de Ciência e Tecnologia UNIFAL-MGDepartamento de Química Faculdade de Ciências UNESPCentro Universitário de Rio Preto UNIRPInstituto de Química UNESP, CP 355Departamento de Química Faculdade de Ciências UNESPInstituto de Química UNESP, CP 355UNIFAL-MGUniversidade Estadual Paulista (Unesp)UNIRPFranzé, J. A.Carvalho, T. F.Gaglieri, C. [UNESP]Caires, F. J. [UNESP]Bannach, G. [UNESP]Castro, R. C.Treu-Filho, O. [UNESP]Ionashiro, M. [UNESP]Mendes, R. A.2018-12-11T17:30:42Z2018-12-11T17:30:42Z2017-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1393-1405application/pdfhttp://dx.doi.org/10.1007/s10973-016-6030-5Journal of Thermal Analysis and Calorimetry, v. 127, n. 2, p. 1393-1405, 2017.1588-29261388-6150http://hdl.handle.net/11449/17851310.1007/s10973-016-6030-52-s2.0-850067570412-s2.0-85006757041.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Thermal Analysis and Calorimetry0,5870,587info:eu-repo/semantics/openAccess2024-04-29T18:17:00Zoai:repositorio.unesp.br:11449/178513Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:08:34.510285Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals
title Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals
spellingShingle Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals
Franzé, J. A.
Bioactivity
DFT
Meloxicam
Thermal behavior
Transition metals
title_short Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals
title_full Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals
title_fullStr Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals
title_full_unstemmed Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals
title_sort Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals
author Franzé, J. A.
author_facet Franzé, J. A.
Carvalho, T. F.
Gaglieri, C. [UNESP]
Caires, F. J. [UNESP]
Bannach, G. [UNESP]
Castro, R. C.
Treu-Filho, O. [UNESP]
Ionashiro, M. [UNESP]
Mendes, R. A.
author_role author
author2 Carvalho, T. F.
Gaglieri, C. [UNESP]
Caires, F. J. [UNESP]
Bannach, G. [UNESP]
Castro, R. C.
Treu-Filho, O. [UNESP]
Ionashiro, M. [UNESP]
Mendes, R. A.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv UNIFAL-MG
Universidade Estadual Paulista (Unesp)
UNIRP
dc.contributor.author.fl_str_mv Franzé, J. A.
Carvalho, T. F.
Gaglieri, C. [UNESP]
Caires, F. J. [UNESP]
Bannach, G. [UNESP]
Castro, R. C.
Treu-Filho, O. [UNESP]
Ionashiro, M. [UNESP]
Mendes, R. A.
dc.subject.por.fl_str_mv Bioactivity
DFT
Meloxicam
Thermal behavior
Transition metals
topic Bioactivity
DFT
Meloxicam
Thermal behavior
Transition metals
description Complexes of meloxicam with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) were prepared by aqueous precipitation. The compounds were characterized by means of X-ray powder diffractometry, infrared spectroscopy, theoretical calculation, elemental analysis (CNH), differential scanning calorimetry, simultaneous TG/DTG-DTA and evolved gas analysis (EGA). The results obtained from the TG/DTG-DTA curves and elemental analysis made it possible to establish the general formula of these compounds as [M(Hmel)2(H2O)2]nH2O, where M = Mn(II), Co(II), Ni(II); Cu(II) and Zn(II); Hmel = meloxicam and n = 2 (Mn, Co, Ni, Zn) and 1 (Cu). The simultaneous TG/DTG-DTA data provided previously unreported information about the thermal stability and thermal decomposition of these compounds in dynamic air and nitrogen atmospheres. The EGA showed the remarkable influence of the atmosphere in the thermal decomposition mechanism of these complexes, and it was also possible to identify the main gaseous products of thermal degradation. The lowest energy model structure of the Mn(II), Ni(II) and Zin(II) complexes has been proposed by using the density functional theory at the B3LYP/6-311++G(d) level of theory, and the theoretical spectra were calculated. The antibacterial activity of the compounds was also evaluated in relation to S. aureus by the diffusion method in agar, and the compounds showed little activity. The anti-inflammatory activity of the meloxicam–copper complex was also evaluated in vivo by the rat paw edema method. The compound showed no anti-inflammatory activity, which may have been due to loss of intrinsic activity or poor oral absorption caused by low solubility.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
2018-12-11T17:30:42Z
2018-12-11T17:30:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10973-016-6030-5
Journal of Thermal Analysis and Calorimetry, v. 127, n. 2, p. 1393-1405, 2017.
1588-2926
1388-6150
http://hdl.handle.net/11449/178513
10.1007/s10973-016-6030-5
2-s2.0-85006757041
2-s2.0-85006757041.pdf
url http://dx.doi.org/10.1007/s10973-016-6030-5
http://hdl.handle.net/11449/178513
identifier_str_mv Journal of Thermal Analysis and Calorimetry, v. 127, n. 2, p. 1393-1405, 2017.
1588-2926
1388-6150
10.1007/s10973-016-6030-5
2-s2.0-85006757041
2-s2.0-85006757041.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Thermal Analysis and Calorimetry
0,587
0,587
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1393-1405
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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