SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-9946202264003 http://hdl.handle.net/11449/231615 |
Resumo: | The COVID-19 pandemic in Brazil has been marked by high infection and death rates. The immune response generated by current vaccination might be influenced by previous natural infection, and baseline estimates may help in the evaluation of vaccine-induced serological response. We evaluated previous SARS-CoV-2 testing (RT-PCR), and performed rapid diagnostic tests (RDT) and high throughput electrochemiluminescence immunoassay (ECLIA) before vaccination among people living with HIV (PLWH), users of antiretroviral prophylaxis (PrEP/PEP), and healthcare professionals in an HIV outpatient clinic (HCP-HC). RDT was positive in 25.7% (95% CI: 19-33%) overall, 31.3% (95% CI: 18-45%) among PLWH, 23.7% (95% CI: 14-34%) in PrEP/PEP users and 21.4% (95% CI: 05-28%) in HCP-HC (p=0.548). Diagnostic RT-PCR testing was very limited, even for symptomatic individuals, and whereas all HCP-HC had one test perfomed, only 35% of the patients (PREP/ PEP/PLWH) were tested (p<0.0001). Adequate monitoring of post-vaccination humoral response and breakthrough infections including those in asymptomatic cases are warranted, especially in immunologically compromised individuals. |
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SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in BrazilHealth care personalsHIVPEPPrEPPrevalenceSARS-CoV-2The COVID-19 pandemic in Brazil has been marked by high infection and death rates. The immune response generated by current vaccination might be influenced by previous natural infection, and baseline estimates may help in the evaluation of vaccine-induced serological response. We evaluated previous SARS-CoV-2 testing (RT-PCR), and performed rapid diagnostic tests (RDT) and high throughput electrochemiluminescence immunoassay (ECLIA) before vaccination among people living with HIV (PLWH), users of antiretroviral prophylaxis (PrEP/PEP), and healthcare professionals in an HIV outpatient clinic (HCP-HC). RDT was positive in 25.7% (95% CI: 19-33%) overall, 31.3% (95% CI: 18-45%) among PLWH, 23.7% (95% CI: 14-34%) in PrEP/PEP users and 21.4% (95% CI: 05-28%) in HCP-HC (p=0.548). Diagnostic RT-PCR testing was very limited, even for symptomatic individuals, and whereas all HCP-HC had one test perfomed, only 35% of the patients (PREP/ PEP/PLWH) were tested (p<0.0001). Adequate monitoring of post-vaccination humoral response and breakthrough infections including those in asymptomatic cases are warranted, especially in immunologically compromised individuals.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Secretaria Municipal de Saúde, São PauloUniversidade do Estado de São Paulo, Campus Botucatu, São PauloInstituto Adolfo Lutz Centro de Laboratório Regional Santo André, São PauloInstituto Adolfo Lutz Centro de Virologia, São PauloInstituto Adolfo Lutz Centro de Imunologia, São PauloCNPq: 24/2019-442776/2019-5Secretaria Municipal de SaúdeUniversidade do Estado de São PauloCentro de Laboratório Regional Santo AndréCentro de VirologiaCentro de ImunologiaMatsuda, Elaine Monteirode Oliveira, Isabela Penterichede Campos, Ivana BarrosAhagon, Cintia MayumiCastejon, Marcia JorgeSilva, Valeria OliveiraManzoni, Fernanda MatsudaLópez-Lopes, Giselle IbetteBrígido, Luís Fernando de Macedo2022-04-29T08:46:35Z2022-04-29T08:46:35Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/S1678-9946202264003Revista do Instituto de Medicina Tropical de Sao Paulo, v. 64.1678-99460036-4665http://hdl.handle.net/11449/23161510.1590/S1678-99462022640032-s2.0-85124275676Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista do Instituto de Medicina Tropical de Sao Pauloinfo:eu-repo/semantics/openAccess2022-04-29T08:46:36Zoai:repositorio.unesp.br:11449/231615Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:44:38.824429Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil |
title |
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil |
spellingShingle |
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil Matsuda, Elaine Monteiro Health care personals HIV PEP PrEP Prevalence SARS-CoV-2 |
title_short |
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil |
title_full |
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil |
title_fullStr |
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil |
title_full_unstemmed |
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil |
title_sort |
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil |
author |
Matsuda, Elaine Monteiro |
author_facet |
Matsuda, Elaine Monteiro de Oliveira, Isabela Penteriche de Campos, Ivana Barros Ahagon, Cintia Mayumi Castejon, Marcia Jorge Silva, Valeria Oliveira Manzoni, Fernanda Matsuda López-Lopes, Giselle Ibette Brígido, Luís Fernando de Macedo |
author_role |
author |
author2 |
de Oliveira, Isabela Penteriche de Campos, Ivana Barros Ahagon, Cintia Mayumi Castejon, Marcia Jorge Silva, Valeria Oliveira Manzoni, Fernanda Matsuda López-Lopes, Giselle Ibette Brígido, Luís Fernando de Macedo |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Secretaria Municipal de Saúde Universidade do Estado de São Paulo Centro de Laboratório Regional Santo André Centro de Virologia Centro de Imunologia |
dc.contributor.author.fl_str_mv |
Matsuda, Elaine Monteiro de Oliveira, Isabela Penteriche de Campos, Ivana Barros Ahagon, Cintia Mayumi Castejon, Marcia Jorge Silva, Valeria Oliveira Manzoni, Fernanda Matsuda López-Lopes, Giselle Ibette Brígido, Luís Fernando de Macedo |
dc.subject.por.fl_str_mv |
Health care personals HIV PEP PrEP Prevalence SARS-CoV-2 |
topic |
Health care personals HIV PEP PrEP Prevalence SARS-CoV-2 |
description |
The COVID-19 pandemic in Brazil has been marked by high infection and death rates. The immune response generated by current vaccination might be influenced by previous natural infection, and baseline estimates may help in the evaluation of vaccine-induced serological response. We evaluated previous SARS-CoV-2 testing (RT-PCR), and performed rapid diagnostic tests (RDT) and high throughput electrochemiluminescence immunoassay (ECLIA) before vaccination among people living with HIV (PLWH), users of antiretroviral prophylaxis (PrEP/PEP), and healthcare professionals in an HIV outpatient clinic (HCP-HC). RDT was positive in 25.7% (95% CI: 19-33%) overall, 31.3% (95% CI: 18-45%) among PLWH, 23.7% (95% CI: 14-34%) in PrEP/PEP users and 21.4% (95% CI: 05-28%) in HCP-HC (p=0.548). Diagnostic RT-PCR testing was very limited, even for symptomatic individuals, and whereas all HCP-HC had one test perfomed, only 35% of the patients (PREP/ PEP/PLWH) were tested (p<0.0001). Adequate monitoring of post-vaccination humoral response and breakthrough infections including those in asymptomatic cases are warranted, especially in immunologically compromised individuals. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:46:35Z 2022-04-29T08:46:35Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-9946202264003 Revista do Instituto de Medicina Tropical de Sao Paulo, v. 64. 1678-9946 0036-4665 http://hdl.handle.net/11449/231615 10.1590/S1678-9946202264003 2-s2.0-85124275676 |
url |
http://dx.doi.org/10.1590/S1678-9946202264003 http://hdl.handle.net/11449/231615 |
identifier_str_mv |
Revista do Instituto de Medicina Tropical de Sao Paulo, v. 64. 1678-9946 0036-4665 10.1590/S1678-9946202264003 2-s2.0-85124275676 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de Sao Paulo |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129353017458688 |