Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin

Detalhes bibliográficos
Autor(a) principal: Shah, Rehmat
Data de Publicação: 2018
Outros Autores: Subhan, Fazal, Sultan, Sayed Mohammad, Ali, Gowhar, Ullah, Ihsan, Ullah, Sami
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/153864
Resumo: Olanzapine and risperidone are widely prescribed atypical antipsychotics used in the treatment of schizophrenia and various other psychiatric disorders. Both of these drugs have been extensively reported to cause Type 2 diabetes mellitus and pancreatitis, however, the mechanism of olanzapine and risperidone-induced toxicity has not been so far unveiled. We, therefore, compared the streptozocininduced pancreatic damage with that of pancreas isolated from olanzapine and risperidone treated rats. It was noticed that fibrotic growth, necrosis and derangement of the pancreatic islet cells caused by streptozocin were more pronounced than olanzapine and risperidone.
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spelling Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocinHistopathology/pancreasAntipsychotic drugs/evaluationOlanzapineRisperidoneOlanzapine and risperidone are widely prescribed atypical antipsychotics used in the treatment of schizophrenia and various other psychiatric disorders. Both of these drugs have been extensively reported to cause Type 2 diabetes mellitus and pancreatitis, however, the mechanism of olanzapine and risperidone-induced toxicity has not been so far unveiled. We, therefore, compared the streptozocininduced pancreatic damage with that of pancreas isolated from olanzapine and risperidone treated rats. It was noticed that fibrotic growth, necrosis and derangement of the pancreatic islet cells caused by streptozocin were more pronounced than olanzapine and risperidone.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/15386410.1590/s2175-97902018000317669Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 3 (2018); e17669Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 3 (2018); e17669Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 3 (2018); e176692175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/153864/150219Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessShah, RehmatSubhan, FazalSultan, Sayed MohammadAli, GowharUllah, IhsanUllah, Sami2019-03-17T13:18:30Zoai:revistas.usp.br:article/153864Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-03-17T13:18:30Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
title Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
spellingShingle Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
Shah, Rehmat
Histopathology/pancreas
Antipsychotic drugs/evaluation
Olanzapine
Risperidone
title_short Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
title_full Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
title_fullStr Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
title_full_unstemmed Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
title_sort Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
author Shah, Rehmat
author_facet Shah, Rehmat
Subhan, Fazal
Sultan, Sayed Mohammad
Ali, Gowhar
Ullah, Ihsan
Ullah, Sami
author_role author
author2 Subhan, Fazal
Sultan, Sayed Mohammad
Ali, Gowhar
Ullah, Ihsan
Ullah, Sami
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Shah, Rehmat
Subhan, Fazal
Sultan, Sayed Mohammad
Ali, Gowhar
Ullah, Ihsan
Ullah, Sami
dc.subject.por.fl_str_mv Histopathology/pancreas
Antipsychotic drugs/evaluation
Olanzapine
Risperidone
topic Histopathology/pancreas
Antipsychotic drugs/evaluation
Olanzapine
Risperidone
description Olanzapine and risperidone are widely prescribed atypical antipsychotics used in the treatment of schizophrenia and various other psychiatric disorders. Both of these drugs have been extensively reported to cause Type 2 diabetes mellitus and pancreatitis, however, the mechanism of olanzapine and risperidone-induced toxicity has not been so far unveiled. We, therefore, compared the streptozocininduced pancreatic damage with that of pancreas isolated from olanzapine and risperidone treated rats. It was noticed that fibrotic growth, necrosis and derangement of the pancreatic islet cells caused by streptozocin were more pronounced than olanzapine and risperidone.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/153864
10.1590/s2175-97902018000317669
url https://www.revistas.usp.br/bjps/article/view/153864
identifier_str_mv 10.1590/s2175-97902018000317669
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/153864/150219
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 3 (2018); e17669
Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 3 (2018); e17669
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 3 (2018); e17669
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
_version_ 1800222913809350656

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