Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy

Detalhes bibliográficos
Autor(a) principal: Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP]
Data de Publicação: 2007
Outros Autores: Souza, L. R. [UNESP], Peraçoli, Maria Terezinha Serrão [UNESP], Pereira, Paulo Câmara Marques [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-91992007000200009
http://hdl.handle.net/11449/69725
Resumo: The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-α, IFN-γ, IL-2, IL-10, and TNF-α type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-α, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-γ had reduced levels in the lipodystrophy group. High TNF-α and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy.
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spelling Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophyCytokinesHIV-1HypertriglyceridemiaLipodystrophyHuman immunodeficiency virusHuman immunodeficiency virus 1The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-α, IFN-γ, IL-2, IL-10, and TNF-α type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-α, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-γ had reduced levels in the lipodystrophy group. High TNF-α and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy.Department of Tropical Diseases Botucatu School of Medicine São Paulo State University, UNESP, Botucatu, São Paulo StateDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, UNESP, Botucatu, São Paulo StateDepartamento de Doenças Tropicais Faculdade de Medicina de Botucatu UNESP, 18618-000, Botucatu, SPDepartment of Tropical Diseases Botucatu School of Medicine São Paulo State University, UNESP, Botucatu, São Paulo StateDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, UNESP, Botucatu, São Paulo StateDepartamento de Doenças Tropicais Faculdade de Medicina de Botucatu UNESP, 18618-000, Botucatu, SPUniversidade Estadual Paulista (Unesp)Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP]Souza, L. R. [UNESP]Peraçoli, Maria Terezinha Serrão [UNESP]Pereira, Paulo Câmara Marques [UNESP]2014-05-27T11:22:30Z2014-05-27T11:22:30Z2007-06-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article509-526application/pdfhttp://dx.doi.org/10.1590/S1678-91992007000200009Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 2, p. 509-526, 2007.1678-9199http://hdl.handle.net/11449/6972510.1590/S1678-91992007000200009S1678-91992007000200009WOS:0002493893000092-s2.0-342508025702-s2.0-34250802570.pdf136532042741820464865573873978060000-0001-5771-8943Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2024-08-15T15:23:00Zoai:repositorio.unesp.br:11449/69725Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
title Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
spellingShingle Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP]
Cytokines
HIV-1
Hypertriglyceridemia
Lipodystrophy
Human immunodeficiency virus
Human immunodeficiency virus 1
title_short Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
title_full Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
title_fullStr Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
title_full_unstemmed Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
title_sort Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
author Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP]
author_facet Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP]
Souza, L. R. [UNESP]
Peraçoli, Maria Terezinha Serrão [UNESP]
Pereira, Paulo Câmara Marques [UNESP]
author_role author
author2 Souza, L. R. [UNESP]
Peraçoli, Maria Terezinha Serrão [UNESP]
Pereira, Paulo Câmara Marques [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP]
Souza, L. R. [UNESP]
Peraçoli, Maria Terezinha Serrão [UNESP]
Pereira, Paulo Câmara Marques [UNESP]
dc.subject.por.fl_str_mv Cytokines
HIV-1
Hypertriglyceridemia
Lipodystrophy
Human immunodeficiency virus
Human immunodeficiency virus 1
topic Cytokines
HIV-1
Hypertriglyceridemia
Lipodystrophy
Human immunodeficiency virus
Human immunodeficiency virus 1
description The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-α, IFN-γ, IL-2, IL-10, and TNF-α type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-α, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-γ had reduced levels in the lipodystrophy group. High TNF-α and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy.
publishDate 2007
dc.date.none.fl_str_mv 2007-06-29
2014-05-27T11:22:30Z
2014-05-27T11:22:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-91992007000200009
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 2, p. 509-526, 2007.
1678-9199
http://hdl.handle.net/11449/69725
10.1590/S1678-91992007000200009
S1678-91992007000200009
WOS:000249389300009
2-s2.0-34250802570
2-s2.0-34250802570.pdf
1365320427418204
6486557387397806
0000-0001-5771-8943
url http://dx.doi.org/10.1590/S1678-91992007000200009
http://hdl.handle.net/11449/69725
identifier_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 2, p. 509-526, 2007.
1678-9199
10.1590/S1678-91992007000200009
S1678-91992007000200009
WOS:000249389300009
2-s2.0-34250802570
2-s2.0-34250802570.pdf
1365320427418204
6486557387397806
0000-0001-5771-8943
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 509-526
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
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instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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