Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992007000200009 http://hdl.handle.net/11449/69725 |
Resumo: | The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-α, IFN-γ, IL-2, IL-10, and TNF-α type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-α, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-γ had reduced levels in the lipodystrophy group. High TNF-α and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy. |
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Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophyCytokinesHIV-1HypertriglyceridemiaLipodystrophyHuman immunodeficiency virusHuman immunodeficiency virus 1The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-α, IFN-γ, IL-2, IL-10, and TNF-α type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-α, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-γ had reduced levels in the lipodystrophy group. High TNF-α and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy.Department of Tropical Diseases Botucatu School of Medicine São Paulo State University, UNESP, Botucatu, São Paulo StateDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, UNESP, Botucatu, São Paulo StateDepartamento de Doenças Tropicais Faculdade de Medicina de Botucatu UNESP, 18618-000, Botucatu, SPDepartment of Tropical Diseases Botucatu School of Medicine São Paulo State University, UNESP, Botucatu, São Paulo StateDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, UNESP, Botucatu, São Paulo StateDepartamento de Doenças Tropicais Faculdade de Medicina de Botucatu UNESP, 18618-000, Botucatu, SPUniversidade Estadual Paulista (Unesp)Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP]Souza, L. R. [UNESP]Peraçoli, Maria Terezinha Serrão [UNESP]Pereira, Paulo Câmara Marques [UNESP]2014-05-27T11:22:30Z2014-05-27T11:22:30Z2007-06-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article509-526application/pdfhttp://dx.doi.org/10.1590/S1678-91992007000200009Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 2, p. 509-526, 2007.1678-9199http://hdl.handle.net/11449/6972510.1590/S1678-91992007000200009S1678-91992007000200009WOS:0002493893000092-s2.0-342508025702-s2.0-34250802570.pdf136532042741820464865573873978060000-0001-5771-8943Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2024-08-15T15:23:00Zoai:repositorio.unesp.br:11449/69725Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
spellingShingle |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP] Cytokines HIV-1 Hypertriglyceridemia Lipodystrophy Human immunodeficiency virus Human immunodeficiency virus 1 |
title_short |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_full |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_fullStr |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_full_unstemmed |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_sort |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
author |
Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP] |
author_facet |
Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP] Souza, L. R. [UNESP] Peraçoli, Maria Terezinha Serrão [UNESP] Pereira, Paulo Câmara Marques [UNESP] |
author_role |
author |
author2 |
Souza, L. R. [UNESP] Peraçoli, Maria Terezinha Serrão [UNESP] Pereira, Paulo Câmara Marques [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pontes-Cardoso, Lizandra Carla Rigoletti [UNESP] Souza, L. R. [UNESP] Peraçoli, Maria Terezinha Serrão [UNESP] Pereira, Paulo Câmara Marques [UNESP] |
dc.subject.por.fl_str_mv |
Cytokines HIV-1 Hypertriglyceridemia Lipodystrophy Human immunodeficiency virus Human immunodeficiency virus 1 |
topic |
Cytokines HIV-1 Hypertriglyceridemia Lipodystrophy Human immunodeficiency virus Human immunodeficiency virus 1 |
description |
The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-α, IFN-γ, IL-2, IL-10, and TNF-α type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-α, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-γ had reduced levels in the lipodystrophy group. High TNF-α and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-06-29 2014-05-27T11:22:30Z 2014-05-27T11:22:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992007000200009 Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 2, p. 509-526, 2007. 1678-9199 http://hdl.handle.net/11449/69725 10.1590/S1678-91992007000200009 S1678-91992007000200009 WOS:000249389300009 2-s2.0-34250802570 2-s2.0-34250802570.pdf 1365320427418204 6486557387397806 0000-0001-5771-8943 |
url |
http://dx.doi.org/10.1590/S1678-91992007000200009 http://hdl.handle.net/11449/69725 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 2, p. 509-526, 2007. 1678-9199 10.1590/S1678-91992007000200009 S1678-91992007000200009 WOS:000249389300009 2-s2.0-34250802570 2-s2.0-34250802570.pdf 1365320427418204 6486557387397806 0000-0001-5771-8943 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases 1.782 0,573 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
509-526 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128153656229888 |