Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction

• Autor(a) principal: Oliveira, Paula G.S. [UNESP]
• Data de Publicação: 2022
• Outros Autores: Schwed, Juliana F. [UNESP], Chiuso-Minicucci, Fernanda [UNESP], Duarte, Sara R.S. [UNESP], Nascimento, Lucas M. [UNESP], Dorna, Mariana S. [UNESP], Costa, Nara A., Okoshi, Katashi [UNESP], Okoshi, Marina P. [UNESP], Azevedo, Paula S. [UNESP], Polegato, Bertha F. [UNESP], Paiva, Sergio A.R. [UNESP], Zornoff, Leonardo A.M. [UNESP], Minicucci, Marcos F. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.hlc.2021.08.018; http://hdl.handle.net/11449/229608
• topic: Growth differentiation factor 8; Muscle mass; Myocardial infarction; Myostatin

Aim: This study aimed to evaluate the association between serum myostatin levels, hospital mortality, and muscle mass and strength following ST-segment elevation myocardial infarction (STEMI). Methods: This was a prospective observational study. Within 48 hours of admission, bioelectrical impedance and handgrip strength were assessed and blood samples collected for myostatin evaluation. Hospital mortality was recorded. A multiple logistic regression model was also constructed, adjusted by parameters that exhibited significant differences in the univariate analysis, to evaluate the association between myostatin levels and hospital mortality. Results: One hundred and two (102) patients were included: mean age was 60.5±10.6 years, 67.6% were male, and 6.9% died during hospital stay. Univariate analysis showed that patients with lower myostatin levels had higher mortality rates. Serum myostatin levels positively correlated with handgrip strength (r=0.355; p<0.001) and appendicular skeletal muscle mass index (r=0.268; p=0.007). Receiver operating characteristic (ROC) curve analysis revealed that lower myostatin levels were associated with hospital mortality at the <2.20 ng/mL cut-off. Multiple logistic regression showed that higher serum myostatin levels were associated with reduced hospital mortality when adjusted by β blocker use (OR, 0.228; 95% CI, 0.054–0.974; p=0.046). Conclusions: Serum myostatin concentrations positively correlated with muscle mass and strength in STEMI patients. Further assessment of serum myostatin association with mortality should be conducted using a larger sample and assessing the additive value to the Global Registry of Acute Coronary Events (GRACE) or thrombolysis in myocardial infarction (TIMI) risk scores.