Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.hlc.2021.08.018 http://hdl.handle.net/11449/229608 |
Resumo: | Aim: This study aimed to evaluate the association between serum myostatin levels, hospital mortality, and muscle mass and strength following ST-segment elevation myocardial infarction (STEMI). Methods: This was a prospective observational study. Within 48 hours of admission, bioelectrical impedance and handgrip strength were assessed and blood samples collected for myostatin evaluation. Hospital mortality was recorded. A multiple logistic regression model was also constructed, adjusted by parameters that exhibited significant differences in the univariate analysis, to evaluate the association between myostatin levels and hospital mortality. Results: One hundred and two (102) patients were included: mean age was 60.5±10.6 years, 67.6% were male, and 6.9% died during hospital stay. Univariate analysis showed that patients with lower myostatin levels had higher mortality rates. Serum myostatin levels positively correlated with handgrip strength (r=0.355; p<0.001) and appendicular skeletal muscle mass index (r=0.268; p=0.007). Receiver operating characteristic (ROC) curve analysis revealed that lower myostatin levels were associated with hospital mortality at the <2.20 ng/mL cut-off. Multiple logistic regression showed that higher serum myostatin levels were associated with reduced hospital mortality when adjusted by β blocker use (OR, 0.228; 95% CI, 0.054–0.974; p=0.046). Conclusions: Serum myostatin concentrations positively correlated with muscle mass and strength in STEMI patients. Further assessment of serum myostatin association with mortality should be conducted using a larger sample and assessing the additive value to the Global Registry of Acute Coronary Events (GRACE) or thrombolysis in myocardial infarction (TIMI) risk scores. |
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Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial InfarctionGrowth differentiation factor 8Muscle massMyocardial infarctionMyostatinAim: This study aimed to evaluate the association between serum myostatin levels, hospital mortality, and muscle mass and strength following ST-segment elevation myocardial infarction (STEMI). Methods: This was a prospective observational study. Within 48 hours of admission, bioelectrical impedance and handgrip strength were assessed and blood samples collected for myostatin evaluation. Hospital mortality was recorded. A multiple logistic regression model was also constructed, adjusted by parameters that exhibited significant differences in the univariate analysis, to evaluate the association between myostatin levels and hospital mortality. Results: One hundred and two (102) patients were included: mean age was 60.5±10.6 years, 67.6% were male, and 6.9% died during hospital stay. Univariate analysis showed that patients with lower myostatin levels had higher mortality rates. Serum myostatin levels positively correlated with handgrip strength (r=0.355; p<0.001) and appendicular skeletal muscle mass index (r=0.268; p=0.007). Receiver operating characteristic (ROC) curve analysis revealed that lower myostatin levels were associated with hospital mortality at the <2.20 ng/mL cut-off. Multiple logistic regression showed that higher serum myostatin levels were associated with reduced hospital mortality when adjusted by β blocker use (OR, 0.228; 95% CI, 0.054–0.974; p=0.046). Conclusions: Serum myostatin concentrations positively correlated with muscle mass and strength in STEMI patients. Further assessment of serum myostatin association with mortality should be conducted using a larger sample and assessing the additive value to the Global Registry of Acute Coronary Events (GRACE) or thrombolysis in myocardial infarction (TIMI) risk scores.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual PaulistaInternal Medicine Department Botucatu Medical School Univ Estadual Paulista UNESPUniversity Hospital Botucatu Medical School Sao Paulo State University UNESPFaculty of Nutrition Univ Federal de Goias UFGInternal Medicine Department Botucatu Medical School Univ Estadual Paulista UNESPUniversity Hospital Botucatu Medical School Sao Paulo State University UNESPUniversidade Estadual Paulista (UNESP)Universidade Federal de Goiás (UFG)Oliveira, Paula G.S. [UNESP]Schwed, Juliana F. [UNESP]Chiuso-Minicucci, Fernanda [UNESP]Duarte, Sara R.S. [UNESP]Nascimento, Lucas M. [UNESP]Dorna, Mariana S. [UNESP]Costa, Nara A.Okoshi, Katashi [UNESP]Okoshi, Marina P. [UNESP]Azevedo, Paula S. [UNESP]Polegato, Bertha F. [UNESP]Paiva, Sergio A.R. [UNESP]Zornoff, Leonardo A.M. [UNESP]Minicucci, Marcos F. [UNESP]2022-04-29T08:33:34Z2022-04-29T08:33:34Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article365-371http://dx.doi.org/10.1016/j.hlc.2021.08.018Heart Lung and Circulation, v. 31, n. 3, p. 365-371, 2022.1444-28921443-9506http://hdl.handle.net/11449/22960810.1016/j.hlc.2021.08.0182-s2.0-85115934575Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHeart Lung and Circulationinfo:eu-repo/semantics/openAccess2024-08-14T17:21:56Zoai:repositorio.unesp.br:11449/229608Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:21:56Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction |
title |
Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction |
spellingShingle |
Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction Oliveira, Paula G.S. [UNESP] Growth differentiation factor 8 Muscle mass Myocardial infarction Myostatin |
title_short |
Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction |
title_full |
Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction |
title_fullStr |
Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction |
title_full_unstemmed |
Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction |
title_sort |
Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction |
author |
Oliveira, Paula G.S. [UNESP] |
author_facet |
Oliveira, Paula G.S. [UNESP] Schwed, Juliana F. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Duarte, Sara R.S. [UNESP] Nascimento, Lucas M. [UNESP] Dorna, Mariana S. [UNESP] Costa, Nara A. Okoshi, Katashi [UNESP] Okoshi, Marina P. [UNESP] Azevedo, Paula S. [UNESP] Polegato, Bertha F. [UNESP] Paiva, Sergio A.R. [UNESP] Zornoff, Leonardo A.M. [UNESP] Minicucci, Marcos F. [UNESP] |
author_role |
author |
author2 |
Schwed, Juliana F. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Duarte, Sara R.S. [UNESP] Nascimento, Lucas M. [UNESP] Dorna, Mariana S. [UNESP] Costa, Nara A. Okoshi, Katashi [UNESP] Okoshi, Marina P. [UNESP] Azevedo, Paula S. [UNESP] Polegato, Bertha F. [UNESP] Paiva, Sergio A.R. [UNESP] Zornoff, Leonardo A.M. [UNESP] Minicucci, Marcos F. [UNESP] |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Federal de Goiás (UFG) |
dc.contributor.author.fl_str_mv |
Oliveira, Paula G.S. [UNESP] Schwed, Juliana F. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Duarte, Sara R.S. [UNESP] Nascimento, Lucas M. [UNESP] Dorna, Mariana S. [UNESP] Costa, Nara A. Okoshi, Katashi [UNESP] Okoshi, Marina P. [UNESP] Azevedo, Paula S. [UNESP] Polegato, Bertha F. [UNESP] Paiva, Sergio A.R. [UNESP] Zornoff, Leonardo A.M. [UNESP] Minicucci, Marcos F. [UNESP] |
dc.subject.por.fl_str_mv |
Growth differentiation factor 8 Muscle mass Myocardial infarction Myostatin |
topic |
Growth differentiation factor 8 Muscle mass Myocardial infarction Myostatin |
description |
Aim: This study aimed to evaluate the association between serum myostatin levels, hospital mortality, and muscle mass and strength following ST-segment elevation myocardial infarction (STEMI). Methods: This was a prospective observational study. Within 48 hours of admission, bioelectrical impedance and handgrip strength were assessed and blood samples collected for myostatin evaluation. Hospital mortality was recorded. A multiple logistic regression model was also constructed, adjusted by parameters that exhibited significant differences in the univariate analysis, to evaluate the association between myostatin levels and hospital mortality. Results: One hundred and two (102) patients were included: mean age was 60.5±10.6 years, 67.6% were male, and 6.9% died during hospital stay. Univariate analysis showed that patients with lower myostatin levels had higher mortality rates. Serum myostatin levels positively correlated with handgrip strength (r=0.355; p<0.001) and appendicular skeletal muscle mass index (r=0.268; p=0.007). Receiver operating characteristic (ROC) curve analysis revealed that lower myostatin levels were associated with hospital mortality at the <2.20 ng/mL cut-off. Multiple logistic regression showed that higher serum myostatin levels were associated with reduced hospital mortality when adjusted by β blocker use (OR, 0.228; 95% CI, 0.054–0.974; p=0.046). Conclusions: Serum myostatin concentrations positively correlated with muscle mass and strength in STEMI patients. Further assessment of serum myostatin association with mortality should be conducted using a larger sample and assessing the additive value to the Global Registry of Acute Coronary Events (GRACE) or thrombolysis in myocardial infarction (TIMI) risk scores. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:33:34Z 2022-04-29T08:33:34Z 2022-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.hlc.2021.08.018 Heart Lung and Circulation, v. 31, n. 3, p. 365-371, 2022. 1444-2892 1443-9506 http://hdl.handle.net/11449/229608 10.1016/j.hlc.2021.08.018 2-s2.0-85115934575 |
url |
http://dx.doi.org/10.1016/j.hlc.2021.08.018 http://hdl.handle.net/11449/229608 |
identifier_str_mv |
Heart Lung and Circulation, v. 31, n. 3, p. 365-371, 2022. 1444-2892 1443-9506 10.1016/j.hlc.2021.08.018 2-s2.0-85115934575 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Heart Lung and Circulation |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
365-371 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128105487794176 |