Endocrine Disruptors and Hypothalamic Sexual Differentiation
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5016/1806-8774.2003v5p87 http://hdl.handle.net/11449/67526 |
Resumo: | The so-called endocrine disruptors have been described as compounds which interfere with the estrogen action in their receptors and may exert a crucial role in the development of the reproductive tract and in the brain sexual differentiation. Thus, conducts and/or exposure to these drugs in the perinatal period that apparently do not endanger the neonate may cause side effects. During embrionary development, the gonads, through discharge of a small quantity of reproductive hormones, will guarantee the phenotype of male or female at birth, as well as actuate in specific areas sexual differentiation of the central nervous system. Several experimental models have shown an interference of drugs acting as endocrine disruptors in hypothalamic sexual differentiation. Thus, reproductive function is impaired by exposure to estrogen in the perinatal life of rats and the mechanisms involved in this effect are distinct for males and females. Perinatal exposure to drugs which may be considered endocrine disrupters may induce an incomplete masculinization and defeminization of the central nervous system. Alterations in these processes, if present, generally are perceived only at puberty or adult reproductive life. These later alterations may include anomalies in the process of fertility or in sexual behavior. |
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Repositório Institucional da UNESP |
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Endocrine Disruptors and Hypothalamic Sexual DifferentiationBrain sexual differentiationEndocrine disruptorsEstrogenFertilityReproductive functionSexual behaviorantiandrogenendocrine disruptorenvironmental chemicalestrogenestrogen receptorunclassified drugxenobiotic agentembryo developmentestrogen activityfertilitygonadhypothalamusimmobilization stressnonhumanperinatal periodreproductionsex differentiationsexual behaviorshort surveyvirilizationThe so-called endocrine disruptors have been described as compounds which interfere with the estrogen action in their receptors and may exert a crucial role in the development of the reproductive tract and in the brain sexual differentiation. Thus, conducts and/or exposure to these drugs in the perinatal period that apparently do not endanger the neonate may cause side effects. During embrionary development, the gonads, through discharge of a small quantity of reproductive hormones, will guarantee the phenotype of male or female at birth, as well as actuate in specific areas sexual differentiation of the central nervous system. Several experimental models have shown an interference of drugs acting as endocrine disruptors in hypothalamic sexual differentiation. Thus, reproductive function is impaired by exposure to estrogen in the perinatal life of rats and the mechanisms involved in this effect are distinct for males and females. Perinatal exposure to drugs which may be considered endocrine disrupters may induce an incomplete masculinization and defeminization of the central nervous system. Alterations in these processes, if present, generally are perceived only at puberty or adult reproductive life. These later alterations may include anomalies in the process of fertility or in sexual behavior.Instituto de Biociências UNESPDepartamento de Farmacologia Instituto de Biociências UNESP, 18618-000, Botucatu, SPInstituto de Biociências UNESPDepartamento de Farmacologia Instituto de Biociências UNESP, 18618-000, Botucatu, SPUniversidade Estadual Paulista (Unesp)Pereira, Oduvaldo C. M. [UNESP]2014-05-27T11:20:58Z2014-05-27T11:20:58Z2003-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article87-94application/pdfhttp://dx.doi.org/10.5016/1806-8774.2003v5p87Annual Review of Biomedical Sciences, v. 5, p. 87-94.1806-8774http://hdl.handle.net/11449/6752610.5016/1806-8774.2003v5p872-s2.0-19424247472-s2.0-1942424747.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnnual Review of Biomedical Sciencesinfo:eu-repo/semantics/openAccess2024-01-03T06:20:56Zoai:repositorio.unesp.br:11449/67526Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:00:04.659043Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Endocrine Disruptors and Hypothalamic Sexual Differentiation |
title |
Endocrine Disruptors and Hypothalamic Sexual Differentiation |
spellingShingle |
Endocrine Disruptors and Hypothalamic Sexual Differentiation Pereira, Oduvaldo C. M. [UNESP] Brain sexual differentiation Endocrine disruptors Estrogen Fertility Reproductive function Sexual behavior antiandrogen endocrine disruptor environmental chemical estrogen estrogen receptor unclassified drug xenobiotic agent embryo development estrogen activity fertility gonad hypothalamus immobilization stress nonhuman perinatal period reproduction sex differentiation sexual behavior short survey virilization |
title_short |
Endocrine Disruptors and Hypothalamic Sexual Differentiation |
title_full |
Endocrine Disruptors and Hypothalamic Sexual Differentiation |
title_fullStr |
Endocrine Disruptors and Hypothalamic Sexual Differentiation |
title_full_unstemmed |
Endocrine Disruptors and Hypothalamic Sexual Differentiation |
title_sort |
Endocrine Disruptors and Hypothalamic Sexual Differentiation |
author |
Pereira, Oduvaldo C. M. [UNESP] |
author_facet |
Pereira, Oduvaldo C. M. [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pereira, Oduvaldo C. M. [UNESP] |
dc.subject.por.fl_str_mv |
Brain sexual differentiation Endocrine disruptors Estrogen Fertility Reproductive function Sexual behavior antiandrogen endocrine disruptor environmental chemical estrogen estrogen receptor unclassified drug xenobiotic agent embryo development estrogen activity fertility gonad hypothalamus immobilization stress nonhuman perinatal period reproduction sex differentiation sexual behavior short survey virilization |
topic |
Brain sexual differentiation Endocrine disruptors Estrogen Fertility Reproductive function Sexual behavior antiandrogen endocrine disruptor environmental chemical estrogen estrogen receptor unclassified drug xenobiotic agent embryo development estrogen activity fertility gonad hypothalamus immobilization stress nonhuman perinatal period reproduction sex differentiation sexual behavior short survey virilization |
description |
The so-called endocrine disruptors have been described as compounds which interfere with the estrogen action in their receptors and may exert a crucial role in the development of the reproductive tract and in the brain sexual differentiation. Thus, conducts and/or exposure to these drugs in the perinatal period that apparently do not endanger the neonate may cause side effects. During embrionary development, the gonads, through discharge of a small quantity of reproductive hormones, will guarantee the phenotype of male or female at birth, as well as actuate in specific areas sexual differentiation of the central nervous system. Several experimental models have shown an interference of drugs acting as endocrine disruptors in hypothalamic sexual differentiation. Thus, reproductive function is impaired by exposure to estrogen in the perinatal life of rats and the mechanisms involved in this effect are distinct for males and females. Perinatal exposure to drugs which may be considered endocrine disrupters may induce an incomplete masculinization and defeminization of the central nervous system. Alterations in these processes, if present, generally are perceived only at puberty or adult reproductive life. These later alterations may include anomalies in the process of fertility or in sexual behavior. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-12-01 2014-05-27T11:20:58Z 2014-05-27T11:20:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5016/1806-8774.2003v5p87 Annual Review of Biomedical Sciences, v. 5, p. 87-94. 1806-8774 http://hdl.handle.net/11449/67526 10.5016/1806-8774.2003v5p87 2-s2.0-1942424747 2-s2.0-1942424747.pdf |
url |
http://dx.doi.org/10.5016/1806-8774.2003v5p87 http://hdl.handle.net/11449/67526 |
identifier_str_mv |
Annual Review of Biomedical Sciences, v. 5, p. 87-94. 1806-8774 10.5016/1806-8774.2003v5p87 2-s2.0-1942424747 2-s2.0-1942424747.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Annual Review of Biomedical Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
87-94 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129382491881472 |