Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1186/1477-5751-10-14 http://hdl.handle.net/11449/72787 |
Resumo: | Background: The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G > C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. Findings. Similar distribution of the allelic and genotypic frequencies were observed between the groups (p > 0.05). Conclusions: The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. © 2011 Scarel-Caminaga et al; licensee BioMed Central Ltd. |
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Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitischemokineCXCR1cytokinegenetic polymorphismperiodontal diseasechemokine receptor CXCR1adultchronic periodontitisdisease predispositionfemalegene frequencygenetic variabilitygenotypehumanmajor clinical studymalesingle nucleotide polymorphismgenetic predispositiongeneticshaplotypemiddle agedAdultChronic PeriodontitisFemaleGenetic Predisposition to DiseaseGenetic VariationHaplotypesHumansMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Interleukin-8ABackground: The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G > C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. Findings. Similar distribution of the allelic and genotypic frequencies were observed between the groups (p > 0.05). Conclusions: The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. © 2011 Scarel-Caminaga et al; licensee BioMed Central Ltd.UNESP - São Paulo State University School of Dentistry at Araraquara Department of Morphology, SPUNESP - São Paulo State University School of Dentistry at Araraquara Department of Oral Diagnosis and Surgery, SPUNESP - São Paulo State University School of Dentistry at Araraquara Department of Morphology, SPUNESP - São Paulo State University School of Dentistry at Araraquara Department of Oral Diagnosis and Surgery, SPUniversidade Estadual Paulista (Unesp)Scarel-Caminaga, Raquel M. [UNESP]Curtis, Karen M.C. [UNESP]Renzi, Rivelto [UNESP]Sogumo, Patrícia M. [UNESP]Anovazzi, Giovana [UNESP]Viana, Aline C. [UNESP]Kim, Yeon J [UNESP]Orrico, Silvana R.P. [UNESP]Cirelli, Joni Augusto [UNESP]2014-05-27T11:26:06Z2014-05-27T11:26:06Z2011-11-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/1477-5751-10-14Journal of Negative Results in BioMedicine, v. 10, n. 1, 2011.1477-5751http://hdl.handle.net/11449/7278710.1186/1477-5751-10-142-s2.0-801552012842-s2.0-80155201284.pdf2628593693450121Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Negative Results in BioMedicine0,483info:eu-repo/semantics/openAccess2023-12-16T06:22:12Zoai:repositorio.unesp.br:11449/72787Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-16T06:22:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis |
| title |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis |
| spellingShingle |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis Scarel-Caminaga, Raquel M. [UNESP] chemokine CXCR1 cytokine genetic polymorphism periodontal disease chemokine receptor CXCR1 adult chronic periodontitis disease predisposition female gene frequency genetic variability genotype human major clinical study male single nucleotide polymorphism genetic predisposition genetics haplotype middle aged Adult Chronic Periodontitis Female Genetic Predisposition to Disease Genetic Variation Haplotypes Humans Male Middle Aged Polymorphism, Single Nucleotide Receptors, Interleukin-8A |
| title_short |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis |
| title_full |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis |
| title_fullStr |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis |
| title_full_unstemmed |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis |
| title_sort |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis |
| author |
Scarel-Caminaga, Raquel M. [UNESP] |
| author_facet |
Scarel-Caminaga, Raquel M. [UNESP] Curtis, Karen M.C. [UNESP] Renzi, Rivelto [UNESP] Sogumo, Patrícia M. [UNESP] Anovazzi, Giovana [UNESP] Viana, Aline C. [UNESP] Kim, Yeon J [UNESP] Orrico, Silvana R.P. [UNESP] Cirelli, Joni Augusto [UNESP] |
| author_role |
author |
| author2 |
Curtis, Karen M.C. [UNESP] Renzi, Rivelto [UNESP] Sogumo, Patrícia M. [UNESP] Anovazzi, Giovana [UNESP] Viana, Aline C. [UNESP] Kim, Yeon J [UNESP] Orrico, Silvana R.P. [UNESP] Cirelli, Joni Augusto [UNESP] |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
Scarel-Caminaga, Raquel M. [UNESP] Curtis, Karen M.C. [UNESP] Renzi, Rivelto [UNESP] Sogumo, Patrícia M. [UNESP] Anovazzi, Giovana [UNESP] Viana, Aline C. [UNESP] Kim, Yeon J [UNESP] Orrico, Silvana R.P. [UNESP] Cirelli, Joni Augusto [UNESP] |
| dc.subject.por.fl_str_mv |
chemokine CXCR1 cytokine genetic polymorphism periodontal disease chemokine receptor CXCR1 adult chronic periodontitis disease predisposition female gene frequency genetic variability genotype human major clinical study male single nucleotide polymorphism genetic predisposition genetics haplotype middle aged Adult Chronic Periodontitis Female Genetic Predisposition to Disease Genetic Variation Haplotypes Humans Male Middle Aged Polymorphism, Single Nucleotide Receptors, Interleukin-8A |
| topic |
chemokine CXCR1 cytokine genetic polymorphism periodontal disease chemokine receptor CXCR1 adult chronic periodontitis disease predisposition female gene frequency genetic variability genotype human major clinical study male single nucleotide polymorphism genetic predisposition genetics haplotype middle aged Adult Chronic Periodontitis Female Genetic Predisposition to Disease Genetic Variation Haplotypes Humans Male Middle Aged Polymorphism, Single Nucleotide Receptors, Interleukin-8A |
| description |
Background: The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G > C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. Findings. Similar distribution of the allelic and genotypic frequencies were observed between the groups (p > 0.05). Conclusions: The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. © 2011 Scarel-Caminaga et al; licensee BioMed Central Ltd. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-11-04 2014-05-27T11:26:06Z 2014-05-27T11:26:06Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1477-5751-10-14 Journal of Negative Results in BioMedicine, v. 10, n. 1, 2011. 1477-5751 http://hdl.handle.net/11449/72787 10.1186/1477-5751-10-14 2-s2.0-80155201284 2-s2.0-80155201284.pdf 2628593693450121 |
| url |
http://dx.doi.org/10.1186/1477-5751-10-14 http://hdl.handle.net/11449/72787 |
| identifier_str_mv |
Journal of Negative Results in BioMedicine, v. 10, n. 1, 2011. 1477-5751 10.1186/1477-5751-10-14 2-s2.0-80155201284 2-s2.0-80155201284.pdf 2628593693450121 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Journal of Negative Results in BioMedicine 0,483 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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