Exposure to crack cocaine causes adverse effects on marine mussels Perna perna

• Autor(a) principal: Maranho, L. A.
• Data de Publicação: 2017
• Outros Autores: Fontes, M. K., Kamimura, A. S. S., Nobre, C. R., Moreno, B. B., Pusceddu, F. H., Cortez, F. S., Lebre, D. T., Marques, J. R., Abessa, D. M. S. [UNESP], Ribeiro, D. A., Pereira, C. D. S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.marpolbul.2017.08.043; http://hdl.handle.net/11449/163503
• topic: Crack cocaine; Bioassays; Cyto-genotoxicity; Marine organism

Our study aimed to evaluate crack cocaine effects in different life stages of the marine mussel Perna perm. For this purpose, fertilization rate, embryo-larval development, lysosomal membrane stability and DNA strand breaks were assessed. Effect concentrations in gametes and in larval development were found after 1 h (IC50 = 23.53 mg.L-1) and 48 h (IC50 = 16.31 mg.L-1),respectively. The highest tested concentration showing no acute toxicity (NOEC) was 10 mg.L-1, while the lowest observed effect concentration (LOEC) was 20 mg.L-1. NOEC concerning embryo-larval development was 0.625 mg.L-1, while the LOEC was 1.25 mg.L-1. Cyto-genotoxic effects were evidenced in mussels exposed to crack cocaine concentrations ranging from 5 to 500 mu g.L-1. Our results report the first data on effects of an illicit drug to marine organisms and should encourage further ecotoxicological studies of these contaminants of emerging concern in coastal ecosystems.