Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma

Detalhes bibliográficos
Autor(a) principal: Tucci, P. J. F.
Data de Publicação: 1979
Outros Autores: Cicogna, A. C., Spadaro, J.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1979/v33n3/33030011.pdf
http://hdl.handle.net/11449/63455
Resumo: Inotropic effects of Propafenon were studied in isovolumic isolated guinea pig hearts submitted to infusion of the drug during 10 minutes. The dosages utilized caused: bradycardia, depression of AV nodal conduction and QRS widening. Simultaneously there was: decrease of the developed pressure (DP) and of the rate of rise of pressure (dp/dt), and elongation of the time of peak pressure. Since there was no clear relation between the heart rate and the inotropic indices (PD and dp/dt), it could be supposed that the depressor effect was not due to impairment of the chronotropism only. After the infusion of Propafenon, the chronotropic effect disapeared after 15 min, while the inotropic state presented a less satisfatory recuperation. The coronary output accompanied the myocardial metabolic needs, that is to say, there was a fall during the period of depressed cardiac function and a later tendency to increase during recovery.
id UNSP_a461df31f2333d0bfbaa36a9428ae52d
oai_identifier_str oai:repositorio.unesp.br:11449/63455
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiogramaAlterations of the mechanics of the isolated guinea pig heart with doses of propafenon that affect the electrocardiographic tracingpropafenonepropiophenone derivativeanimal experimentelectrocardiographyguinea pigheartin vitro studyisolated heartanimalblood pressurebradycardiadrug effectheart muscle conduction systemheart rateAnimalBlood PressureBradycardiaElectrocardiographyEnglish AbstractGuinea PigsHeart Conduction SystemHeart RatePropafenonePropiophenonesInotropic effects of Propafenon were studied in isovolumic isolated guinea pig hearts submitted to infusion of the drug during 10 minutes. The dosages utilized caused: bradycardia, depression of AV nodal conduction and QRS widening. Simultaneously there was: decrease of the developed pressure (DP) and of the rate of rise of pressure (dp/dt), and elongation of the time of peak pressure. Since there was no clear relation between the heart rate and the inotropic indices (PD and dp/dt), it could be supposed that the depressor effect was not due to impairment of the chronotropism only. After the infusion of Propafenon, the chronotropic effect disapeared after 15 min, while the inotropic state presented a less satisfatory recuperation. The coronary output accompanied the myocardial metabolic needs, that is to say, there was a fall during the period of depressed cardiac function and a later tendency to increase during recovery.Universidade Estadual Paulista (Unesp)Tucci, P. J. F.Cicogna, A. C.Spadaro, J.2014-05-26T16:24:06Z2014-05-26T16:24:06Z1979-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article229-232application/pdfhttp://www.arquivosonline.com.br/pesquisartigos/Pdfs/1979/v33n3/33030011.pdfArquivos Brasileiros de Cardiologia, v. 33, n. 3, p. 229-232, 1979.0066-782Xhttp://hdl.handle.net/11449/634552-s2.0-00185107172-s2.0-0018510717.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2023-10-08T06:04:20Zoai:repositorio.unesp.br:11449/63455Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T11:48:31.230582Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
Alterations of the mechanics of the isolated guinea pig heart with doses of propafenon that affect the electrocardiographic tracing
title Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
spellingShingle Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
Tucci, P. J. F.
propafenone
propiophenone derivative
animal experiment
electrocardiography
guinea pig
heart
in vitro study
isolated heart
animal
blood pressure
bradycardia
drug effect
heart muscle conduction system
heart rate
Animal
Blood Pressure
Bradycardia
Electrocardiography
English Abstract
Guinea Pigs
Heart Conduction System
Heart Rate
Propafenone
Propiophenones
title_short Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
title_full Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
title_fullStr Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
title_full_unstemmed Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
title_sort Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
author Tucci, P. J. F.
author_facet Tucci, P. J. F.
Cicogna, A. C.
Spadaro, J.
author_role author
author2 Cicogna, A. C.
Spadaro, J.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Tucci, P. J. F.
Cicogna, A. C.
Spadaro, J.
dc.subject.por.fl_str_mv propafenone
propiophenone derivative
animal experiment
electrocardiography
guinea pig
heart
in vitro study
isolated heart
animal
blood pressure
bradycardia
drug effect
heart muscle conduction system
heart rate
Animal
Blood Pressure
Bradycardia
Electrocardiography
English Abstract
Guinea Pigs
Heart Conduction System
Heart Rate
Propafenone
Propiophenones
topic propafenone
propiophenone derivative
animal experiment
electrocardiography
guinea pig
heart
in vitro study
isolated heart
animal
blood pressure
bradycardia
drug effect
heart muscle conduction system
heart rate
Animal
Blood Pressure
Bradycardia
Electrocardiography
English Abstract
Guinea Pigs
Heart Conduction System
Heart Rate
Propafenone
Propiophenones
description Inotropic effects of Propafenon were studied in isovolumic isolated guinea pig hearts submitted to infusion of the drug during 10 minutes. The dosages utilized caused: bradycardia, depression of AV nodal conduction and QRS widening. Simultaneously there was: decrease of the developed pressure (DP) and of the rate of rise of pressure (dp/dt), and elongation of the time of peak pressure. Since there was no clear relation between the heart rate and the inotropic indices (PD and dp/dt), it could be supposed that the depressor effect was not due to impairment of the chronotropism only. After the infusion of Propafenon, the chronotropic effect disapeared after 15 min, while the inotropic state presented a less satisfatory recuperation. The coronary output accompanied the myocardial metabolic needs, that is to say, there was a fall during the period of depressed cardiac function and a later tendency to increase during recovery.
publishDate 1979
dc.date.none.fl_str_mv 1979-12-01
2014-05-26T16:24:06Z
2014-05-26T16:24:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1979/v33n3/33030011.pdf
Arquivos Brasileiros de Cardiologia, v. 33, n. 3, p. 229-232, 1979.
0066-782X
http://hdl.handle.net/11449/63455
2-s2.0-0018510717
2-s2.0-0018510717.pdf
url http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1979/v33n3/33030011.pdf
http://hdl.handle.net/11449/63455
identifier_str_mv Arquivos Brasileiros de Cardiologia, v. 33, n. 3, p. 229-232, 1979.
0066-782X
2-s2.0-0018510717
2-s2.0-0018510717.pdf
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
1.318
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 229-232
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1803045887949144064

Registros relacionados