Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma
Autor(a) principal: | |
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Data de Publicação: | 1979 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1979/v33n3/33030011.pdf http://hdl.handle.net/11449/63455 |
Resumo: | Inotropic effects of Propafenon were studied in isovolumic isolated guinea pig hearts submitted to infusion of the drug during 10 minutes. The dosages utilized caused: bradycardia, depression of AV nodal conduction and QRS widening. Simultaneously there was: decrease of the developed pressure (DP) and of the rate of rise of pressure (dp/dt), and elongation of the time of peak pressure. Since there was no clear relation between the heart rate and the inotropic indices (PD and dp/dt), it could be supposed that the depressor effect was not due to impairment of the chronotropism only. After the infusion of Propafenon, the chronotropic effect disapeared after 15 min, while the inotropic state presented a less satisfatory recuperation. The coronary output accompanied the myocardial metabolic needs, that is to say, there was a fall during the period of depressed cardiac function and a later tendency to increase during recovery. |
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Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiogramaAlterations of the mechanics of the isolated guinea pig heart with doses of propafenon that affect the electrocardiographic tracingpropafenonepropiophenone derivativeanimal experimentelectrocardiographyguinea pigheartin vitro studyisolated heartanimalblood pressurebradycardiadrug effectheart muscle conduction systemheart rateAnimalBlood PressureBradycardiaElectrocardiographyEnglish AbstractGuinea PigsHeart Conduction SystemHeart RatePropafenonePropiophenonesInotropic effects of Propafenon were studied in isovolumic isolated guinea pig hearts submitted to infusion of the drug during 10 minutes. The dosages utilized caused: bradycardia, depression of AV nodal conduction and QRS widening. Simultaneously there was: decrease of the developed pressure (DP) and of the rate of rise of pressure (dp/dt), and elongation of the time of peak pressure. Since there was no clear relation between the heart rate and the inotropic indices (PD and dp/dt), it could be supposed that the depressor effect was not due to impairment of the chronotropism only. After the infusion of Propafenon, the chronotropic effect disapeared after 15 min, while the inotropic state presented a less satisfatory recuperation. The coronary output accompanied the myocardial metabolic needs, that is to say, there was a fall during the period of depressed cardiac function and a later tendency to increase during recovery.Universidade Estadual Paulista (Unesp)Tucci, P. J. F.Cicogna, A. C.Spadaro, J.2014-05-26T16:24:06Z2014-05-26T16:24:06Z1979-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article229-232application/pdfhttp://www.arquivosonline.com.br/pesquisartigos/Pdfs/1979/v33n3/33030011.pdfArquivos Brasileiros de Cardiologia, v. 33, n. 3, p. 229-232, 1979.0066-782Xhttp://hdl.handle.net/11449/634552-s2.0-00185107172-s2.0-0018510717.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2023-10-08T06:04:20Zoai:repositorio.unesp.br:11449/63455Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:19:16.535367Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma Alterations of the mechanics of the isolated guinea pig heart with doses of propafenon that affect the electrocardiographic tracing |
title |
Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma |
spellingShingle |
Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma Tucci, P. J. F. propafenone propiophenone derivative animal experiment electrocardiography guinea pig heart in vitro study isolated heart animal blood pressure bradycardia drug effect heart muscle conduction system heart rate Animal Blood Pressure Bradycardia Electrocardiography English Abstract Guinea Pigs Heart Conduction System Heart Rate Propafenone Propiophenones |
title_short |
Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma |
title_full |
Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma |
title_fullStr |
Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma |
title_full_unstemmed |
Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma |
title_sort |
Modificacoes na ação mecânica do coração isolado de cobaia por doses de propafenon capazes de alterar o eletrocardiograma |
author |
Tucci, P. J. F. |
author_facet |
Tucci, P. J. F. Cicogna, A. C. Spadaro, J. |
author_role |
author |
author2 |
Cicogna, A. C. Spadaro, J. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Tucci, P. J. F. Cicogna, A. C. Spadaro, J. |
dc.subject.por.fl_str_mv |
propafenone propiophenone derivative animal experiment electrocardiography guinea pig heart in vitro study isolated heart animal blood pressure bradycardia drug effect heart muscle conduction system heart rate Animal Blood Pressure Bradycardia Electrocardiography English Abstract Guinea Pigs Heart Conduction System Heart Rate Propafenone Propiophenones |
topic |
propafenone propiophenone derivative animal experiment electrocardiography guinea pig heart in vitro study isolated heart animal blood pressure bradycardia drug effect heart muscle conduction system heart rate Animal Blood Pressure Bradycardia Electrocardiography English Abstract Guinea Pigs Heart Conduction System Heart Rate Propafenone Propiophenones |
description |
Inotropic effects of Propafenon were studied in isovolumic isolated guinea pig hearts submitted to infusion of the drug during 10 minutes. The dosages utilized caused: bradycardia, depression of AV nodal conduction and QRS widening. Simultaneously there was: decrease of the developed pressure (DP) and of the rate of rise of pressure (dp/dt), and elongation of the time of peak pressure. Since there was no clear relation between the heart rate and the inotropic indices (PD and dp/dt), it could be supposed that the depressor effect was not due to impairment of the chronotropism only. After the infusion of Propafenon, the chronotropic effect disapeared after 15 min, while the inotropic state presented a less satisfatory recuperation. The coronary output accompanied the myocardial metabolic needs, that is to say, there was a fall during the period of depressed cardiac function and a later tendency to increase during recovery. |
publishDate |
1979 |
dc.date.none.fl_str_mv |
1979-12-01 2014-05-26T16:24:06Z 2014-05-26T16:24:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1979/v33n3/33030011.pdf Arquivos Brasileiros de Cardiologia, v. 33, n. 3, p. 229-232, 1979. 0066-782X http://hdl.handle.net/11449/63455 2-s2.0-0018510717 2-s2.0-0018510717.pdf |
url |
http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1979/v33n3/33030011.pdf http://hdl.handle.net/11449/63455 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia, v. 33, n. 3, p. 229-232, 1979. 0066-782X 2-s2.0-0018510717 2-s2.0-0018510717.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia 1.318 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
229-232 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128346872086528 |