Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers

Detalhes bibliográficos
Autor(a) principal: Facin, Andréia Coutinho [UNESP]
Data de Publicação: 2020
Outros Autores: Uscategui, Ricardo Andres Ramirez, Maronezi, Marjury Cristina [UNESP], Pavan, Letícia [UNESP], Menezes, Mareliza Possa [UNESP], Montanhim, Gabriel Luiz [UNESP], Camacho, Aparecido Antonio [UNESP], Feliciano, Marcus Antônio Rossi, Moraes, Paola Castro [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1038/s41598-020-73209-7
http://hdl.handle.net/11449/208004
Resumo: The purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome.
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spelling Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkersThe purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Clinic and Veterinary Surgery São Paulo State University (UNESP) School of Agricultural and Veterinarian SciencesInstitute of Agrarian Sciences Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM)Department of Farm Animals Federal University of Santa Maria (UFSM)Department of Clinic and Veterinary Surgery São Paulo State University (UNESP) School of Agricultural and Veterinarian SciencesCNPq: 130820/2018-0Universidade Estadual Paulista (Unesp)Universidade Federal de Viçosa (UFV)Universidade Federal de Sergipe (UFS)Facin, Andréia Coutinho [UNESP]Uscategui, Ricardo Andres RamirezMaronezi, Marjury Cristina [UNESP]Pavan, Letícia [UNESP]Menezes, Mareliza Possa [UNESP]Montanhim, Gabriel Luiz [UNESP]Camacho, Aparecido Antonio [UNESP]Feliciano, Marcus Antônio RossiMoraes, Paola Castro [UNESP]2021-06-25T11:04:41Z2021-06-25T11:04:41Z2020-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-020-73209-7Scientific Reports, v. 10, n. 1, 2020.2045-2322http://hdl.handle.net/11449/20800410.1038/s41598-020-73209-72-s2.0-85091722383Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reportsinfo:eu-repo/semantics/openAccess2024-06-06T14:09:26Zoai:repositorio.unesp.br:11449/208004Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:31:30.707548Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
title Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
spellingShingle Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
Facin, Andréia Coutinho [UNESP]
title_short Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
title_full Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
title_fullStr Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
title_full_unstemmed Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
title_sort Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
author Facin, Andréia Coutinho [UNESP]
author_facet Facin, Andréia Coutinho [UNESP]
Uscategui, Ricardo Andres Ramirez
Maronezi, Marjury Cristina [UNESP]
Pavan, Letícia [UNESP]
Menezes, Mareliza Possa [UNESP]
Montanhim, Gabriel Luiz [UNESP]
Camacho, Aparecido Antonio [UNESP]
Feliciano, Marcus Antônio Rossi
Moraes, Paola Castro [UNESP]
author_role author
author2 Uscategui, Ricardo Andres Ramirez
Maronezi, Marjury Cristina [UNESP]
Pavan, Letícia [UNESP]
Menezes, Mareliza Possa [UNESP]
Montanhim, Gabriel Luiz [UNESP]
Camacho, Aparecido Antonio [UNESP]
Feliciano, Marcus Antônio Rossi
Moraes, Paola Castro [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Viçosa (UFV)
Universidade Federal de Sergipe (UFS)
dc.contributor.author.fl_str_mv Facin, Andréia Coutinho [UNESP]
Uscategui, Ricardo Andres Ramirez
Maronezi, Marjury Cristina [UNESP]
Pavan, Letícia [UNESP]
Menezes, Mareliza Possa [UNESP]
Montanhim, Gabriel Luiz [UNESP]
Camacho, Aparecido Antonio [UNESP]
Feliciano, Marcus Antônio Rossi
Moraes, Paola Castro [UNESP]
description The purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-01
2021-06-25T11:04:41Z
2021-06-25T11:04:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1038/s41598-020-73209-7
Scientific Reports, v. 10, n. 1, 2020.
2045-2322
http://hdl.handle.net/11449/208004
10.1038/s41598-020-73209-7
2-s2.0-85091722383
url http://dx.doi.org/10.1038/s41598-020-73209-7
http://hdl.handle.net/11449/208004
identifier_str_mv Scientific Reports, v. 10, n. 1, 2020.
2045-2322
10.1038/s41598-020-73209-7
2-s2.0-85091722383
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Scientific Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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