Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1038/s41598-020-73209-7 http://hdl.handle.net/11449/208004 |
Resumo: | The purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome. |
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spelling |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkersThe purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Clinic and Veterinary Surgery São Paulo State University (UNESP) School of Agricultural and Veterinarian SciencesInstitute of Agrarian Sciences Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM)Department of Farm Animals Federal University of Santa Maria (UFSM)Department of Clinic and Veterinary Surgery São Paulo State University (UNESP) School of Agricultural and Veterinarian SciencesCNPq: 130820/2018-0Universidade Estadual Paulista (Unesp)Universidade Federal de Viçosa (UFV)Universidade Federal de Sergipe (UFS)Facin, Andréia Coutinho [UNESP]Uscategui, Ricardo Andres RamirezMaronezi, Marjury Cristina [UNESP]Pavan, Letícia [UNESP]Menezes, Mareliza Possa [UNESP]Montanhim, Gabriel Luiz [UNESP]Camacho, Aparecido Antonio [UNESP]Feliciano, Marcus Antônio RossiMoraes, Paola Castro [UNESP]2021-06-25T11:04:41Z2021-06-25T11:04:41Z2020-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-020-73209-7Scientific Reports, v. 10, n. 1, 2020.2045-2322http://hdl.handle.net/11449/20800410.1038/s41598-020-73209-72-s2.0-85091722383Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reportsinfo:eu-repo/semantics/openAccess2024-06-06T14:09:26Zoai:repositorio.unesp.br:11449/208004Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:31:30.707548Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers |
title |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers |
spellingShingle |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers Facin, Andréia Coutinho [UNESP] |
title_short |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers |
title_full |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers |
title_fullStr |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers |
title_full_unstemmed |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers |
title_sort |
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers |
author |
Facin, Andréia Coutinho [UNESP] |
author_facet |
Facin, Andréia Coutinho [UNESP] Uscategui, Ricardo Andres Ramirez Maronezi, Marjury Cristina [UNESP] Pavan, Letícia [UNESP] Menezes, Mareliza Possa [UNESP] Montanhim, Gabriel Luiz [UNESP] Camacho, Aparecido Antonio [UNESP] Feliciano, Marcus Antônio Rossi Moraes, Paola Castro [UNESP] |
author_role |
author |
author2 |
Uscategui, Ricardo Andres Ramirez Maronezi, Marjury Cristina [UNESP] Pavan, Letícia [UNESP] Menezes, Mareliza Possa [UNESP] Montanhim, Gabriel Luiz [UNESP] Camacho, Aparecido Antonio [UNESP] Feliciano, Marcus Antônio Rossi Moraes, Paola Castro [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Viçosa (UFV) Universidade Federal de Sergipe (UFS) |
dc.contributor.author.fl_str_mv |
Facin, Andréia Coutinho [UNESP] Uscategui, Ricardo Andres Ramirez Maronezi, Marjury Cristina [UNESP] Pavan, Letícia [UNESP] Menezes, Mareliza Possa [UNESP] Montanhim, Gabriel Luiz [UNESP] Camacho, Aparecido Antonio [UNESP] Feliciano, Marcus Antônio Rossi Moraes, Paola Castro [UNESP] |
description |
The purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 2021-06-25T11:04:41Z 2021-06-25T11:04:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-020-73209-7 Scientific Reports, v. 10, n. 1, 2020. 2045-2322 http://hdl.handle.net/11449/208004 10.1038/s41598-020-73209-7 2-s2.0-85091722383 |
url |
http://dx.doi.org/10.1038/s41598-020-73209-7 http://hdl.handle.net/11449/208004 |
identifier_str_mv |
Scientific Reports, v. 10, n. 1, 2020. 2045-2322 10.1038/s41598-020-73209-7 2-s2.0-85091722383 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128667283357696 |