Genomic regions associated with the position and number of hair whorls in horses
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ani11102925 http://hdl.handle.net/11449/233631 |
Resumo: | The position and number of hair whorls have been associated with the behavior, temperament, and laterality of horses. The easy observation of whorls assists in the prediction of reactivity, and thus permits the development of better measures of handling, training, mounting, and riding horses. However, little is known about the genetics involved in the formation of hair whorls. Therefore, the aim of this study was to perform a genome-wide association analysis to identify chromosome regions and candidate genes associated with hair whorl traits. Data from 342 Quarter Horses genotyped for approximately 53,000 SNPs were used in an association study using a single-step procedure. The following traits were analyzed: vertical position of hair whorl on the head, number of whorls on the head, and number of whorls on the left and right sides of the neck. The traits had between one and three genomic windows associated. Each of them explained at least 4% of the additive variance. The windows accounted for 20–80% of additive variance for each trait analyzed. Many of the prospected genes are related to hair follicle growth. Some of these genes exert a pleiotropic effect on neurological and behavioral traits. This is the first indication of biological and physiological activity that might explain the association of hair whorls and temperament. |
id |
UNSP_a591fe2261b0aad81152e801c3bd1f9c |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/233631 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Genomic regions associated with the position and number of hair whorls in horsesBehaviorHair follicleQuarter HorseSNPTemperamentThe position and number of hair whorls have been associated with the behavior, temperament, and laterality of horses. The easy observation of whorls assists in the prediction of reactivity, and thus permits the development of better measures of handling, training, mounting, and riding horses. However, little is known about the genetics involved in the formation of hair whorls. Therefore, the aim of this study was to perform a genome-wide association analysis to identify chromosome regions and candidate genes associated with hair whorl traits. Data from 342 Quarter Horses genotyped for approximately 53,000 SNPs were used in an association study using a single-step procedure. The following traits were analyzed: vertical position of hair whorl on the head, number of whorls on the head, and number of whorls on the left and right sides of the neck. The traits had between one and three genomic windows associated. Each of them explained at least 4% of the additive variance. The windows accounted for 20–80% of additive variance for each trait analyzed. Many of the prospected genes are related to hair follicle growth. Some of these genes exert a pleiotropic effect on neurological and behavioral traits. This is the first indication of biological and physiological activity that might explain the association of hair whorls and temperament.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Escola de Medicina Veterinária e Zootecnia Universidade Federal da Bahia (UFBA)Departamento de Melhoramento e Nutrição Animal Universidade Estadual Paulista (Unesp)Departamento de Melhoramento e Nutrição Animal Universidade Estadual Paulista (Unesp)FAPESP: 2014/20207-1Universidade Federal da Bahia (UFBA)Universidade Estadual Paulista (UNESP)Lima, Diogo Felipe Pereira de Assisda Cruz, Valdecy Aparecida RochaPereira, Guilherme Luís [UNESP]Curi, Rogério Abdallah [UNESP]Costa, Raphael Bermalde Camargo, Gregório Miguel Ferreira2022-05-01T09:31:03Z2022-05-01T09:31:03Z2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ani11102925Animals, v. 11, n. 10, 2021.2076-2615http://hdl.handle.net/11449/23363110.3390/ani111029252-s2.0-85116680266Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnimalsinfo:eu-repo/semantics/openAccess2024-09-06T18:55:50Zoai:repositorio.unesp.br:11449/233631Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-06T18:55:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genomic regions associated with the position and number of hair whorls in horses |
title |
Genomic regions associated with the position and number of hair whorls in horses |
spellingShingle |
Genomic regions associated with the position and number of hair whorls in horses Lima, Diogo Felipe Pereira de Assis Behavior Hair follicle Quarter Horse SNP Temperament |
title_short |
Genomic regions associated with the position and number of hair whorls in horses |
title_full |
Genomic regions associated with the position and number of hair whorls in horses |
title_fullStr |
Genomic regions associated with the position and number of hair whorls in horses |
title_full_unstemmed |
Genomic regions associated with the position and number of hair whorls in horses |
title_sort |
Genomic regions associated with the position and number of hair whorls in horses |
author |
Lima, Diogo Felipe Pereira de Assis |
author_facet |
Lima, Diogo Felipe Pereira de Assis da Cruz, Valdecy Aparecida Rocha Pereira, Guilherme Luís [UNESP] Curi, Rogério Abdallah [UNESP] Costa, Raphael Bermal de Camargo, Gregório Miguel Ferreira |
author_role |
author |
author2 |
da Cruz, Valdecy Aparecida Rocha Pereira, Guilherme Luís [UNESP] Curi, Rogério Abdallah [UNESP] Costa, Raphael Bermal de Camargo, Gregório Miguel Ferreira |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal da Bahia (UFBA) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Lima, Diogo Felipe Pereira de Assis da Cruz, Valdecy Aparecida Rocha Pereira, Guilherme Luís [UNESP] Curi, Rogério Abdallah [UNESP] Costa, Raphael Bermal de Camargo, Gregório Miguel Ferreira |
dc.subject.por.fl_str_mv |
Behavior Hair follicle Quarter Horse SNP Temperament |
topic |
Behavior Hair follicle Quarter Horse SNP Temperament |
description |
The position and number of hair whorls have been associated with the behavior, temperament, and laterality of horses. The easy observation of whorls assists in the prediction of reactivity, and thus permits the development of better measures of handling, training, mounting, and riding horses. However, little is known about the genetics involved in the formation of hair whorls. Therefore, the aim of this study was to perform a genome-wide association analysis to identify chromosome regions and candidate genes associated with hair whorl traits. Data from 342 Quarter Horses genotyped for approximately 53,000 SNPs were used in an association study using a single-step procedure. The following traits were analyzed: vertical position of hair whorl on the head, number of whorls on the head, and number of whorls on the left and right sides of the neck. The traits had between one and three genomic windows associated. Each of them explained at least 4% of the additive variance. The windows accounted for 20–80% of additive variance for each trait analyzed. Many of the prospected genes are related to hair follicle growth. Some of these genes exert a pleiotropic effect on neurological and behavioral traits. This is the first indication of biological and physiological activity that might explain the association of hair whorls and temperament. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-01 2022-05-01T09:31:03Z 2022-05-01T09:31:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ani11102925 Animals, v. 11, n. 10, 2021. 2076-2615 http://hdl.handle.net/11449/233631 10.3390/ani11102925 2-s2.0-85116680266 |
url |
http://dx.doi.org/10.3390/ani11102925 http://hdl.handle.net/11449/233631 |
identifier_str_mv |
Animals, v. 11, n. 10, 2021. 2076-2615 10.3390/ani11102925 2-s2.0-85116680266 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Animals |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546613695578112 |