Genomic regions associated with the position and number of hair whorls in horses

Detalhes bibliográficos
Autor(a) principal: Lima, Diogo Felipe Pereira de Assis
Data de Publicação: 2021
Outros Autores: da Cruz, Valdecy Aparecida Rocha, Pereira, Guilherme Luís [UNESP], Curi, Rogério Abdallah [UNESP], Costa, Raphael Bermal, de Camargo, Gregório Miguel Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/ani11102925
http://hdl.handle.net/11449/233631
Resumo: The position and number of hair whorls have been associated with the behavior, temperament, and laterality of horses. The easy observation of whorls assists in the prediction of reactivity, and thus permits the development of better measures of handling, training, mounting, and riding horses. However, little is known about the genetics involved in the formation of hair whorls. Therefore, the aim of this study was to perform a genome-wide association analysis to identify chromosome regions and candidate genes associated with hair whorl traits. Data from 342 Quarter Horses genotyped for approximately 53,000 SNPs were used in an association study using a single-step procedure. The following traits were analyzed: vertical position of hair whorl on the head, number of whorls on the head, and number of whorls on the left and right sides of the neck. The traits had between one and three genomic windows associated. Each of them explained at least 4% of the additive variance. The windows accounted for 20–80% of additive variance for each trait analyzed. Many of the prospected genes are related to hair follicle growth. Some of these genes exert a pleiotropic effect on neurological and behavioral traits. This is the first indication of biological and physiological activity that might explain the association of hair whorls and temperament.
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spelling Genomic regions associated with the position and number of hair whorls in horsesBehaviorHair follicleQuarter HorseSNPTemperamentThe position and number of hair whorls have been associated with the behavior, temperament, and laterality of horses. The easy observation of whorls assists in the prediction of reactivity, and thus permits the development of better measures of handling, training, mounting, and riding horses. However, little is known about the genetics involved in the formation of hair whorls. Therefore, the aim of this study was to perform a genome-wide association analysis to identify chromosome regions and candidate genes associated with hair whorl traits. Data from 342 Quarter Horses genotyped for approximately 53,000 SNPs were used in an association study using a single-step procedure. The following traits were analyzed: vertical position of hair whorl on the head, number of whorls on the head, and number of whorls on the left and right sides of the neck. The traits had between one and three genomic windows associated. Each of them explained at least 4% of the additive variance. The windows accounted for 20–80% of additive variance for each trait analyzed. Many of the prospected genes are related to hair follicle growth. Some of these genes exert a pleiotropic effect on neurological and behavioral traits. This is the first indication of biological and physiological activity that might explain the association of hair whorls and temperament.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Escola de Medicina Veterinária e Zootecnia Universidade Federal da Bahia (UFBA)Departamento de Melhoramento e Nutrição Animal Universidade Estadual Paulista (Unesp)Departamento de Melhoramento e Nutrição Animal Universidade Estadual Paulista (Unesp)FAPESP: 2014/20207-1Universidade Federal da Bahia (UFBA)Universidade Estadual Paulista (UNESP)Lima, Diogo Felipe Pereira de Assisda Cruz, Valdecy Aparecida RochaPereira, Guilherme Luís [UNESP]Curi, Rogério Abdallah [UNESP]Costa, Raphael Bermalde Camargo, Gregório Miguel Ferreira2022-05-01T09:31:03Z2022-05-01T09:31:03Z2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ani11102925Animals, v. 11, n. 10, 2021.2076-2615http://hdl.handle.net/11449/23363110.3390/ani111029252-s2.0-85116680266Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnimalsinfo:eu-repo/semantics/openAccess2024-09-06T18:55:50Zoai:repositorio.unesp.br:11449/233631Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-06T18:55:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Genomic regions associated with the position and number of hair whorls in horses
title Genomic regions associated with the position and number of hair whorls in horses
spellingShingle Genomic regions associated with the position and number of hair whorls in horses
Lima, Diogo Felipe Pereira de Assis
Behavior
Hair follicle
Quarter Horse
SNP
Temperament
title_short Genomic regions associated with the position and number of hair whorls in horses
title_full Genomic regions associated with the position and number of hair whorls in horses
title_fullStr Genomic regions associated with the position and number of hair whorls in horses
title_full_unstemmed Genomic regions associated with the position and number of hair whorls in horses
title_sort Genomic regions associated with the position and number of hair whorls in horses
author Lima, Diogo Felipe Pereira de Assis
author_facet Lima, Diogo Felipe Pereira de Assis
da Cruz, Valdecy Aparecida Rocha
Pereira, Guilherme Luís [UNESP]
Curi, Rogério Abdallah [UNESP]
Costa, Raphael Bermal
de Camargo, Gregório Miguel Ferreira
author_role author
author2 da Cruz, Valdecy Aparecida Rocha
Pereira, Guilherme Luís [UNESP]
Curi, Rogério Abdallah [UNESP]
Costa, Raphael Bermal
de Camargo, Gregório Miguel Ferreira
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal da Bahia (UFBA)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Lima, Diogo Felipe Pereira de Assis
da Cruz, Valdecy Aparecida Rocha
Pereira, Guilherme Luís [UNESP]
Curi, Rogério Abdallah [UNESP]
Costa, Raphael Bermal
de Camargo, Gregório Miguel Ferreira
dc.subject.por.fl_str_mv Behavior
Hair follicle
Quarter Horse
SNP
Temperament
topic Behavior
Hair follicle
Quarter Horse
SNP
Temperament
description The position and number of hair whorls have been associated with the behavior, temperament, and laterality of horses. The easy observation of whorls assists in the prediction of reactivity, and thus permits the development of better measures of handling, training, mounting, and riding horses. However, little is known about the genetics involved in the formation of hair whorls. Therefore, the aim of this study was to perform a genome-wide association analysis to identify chromosome regions and candidate genes associated with hair whorl traits. Data from 342 Quarter Horses genotyped for approximately 53,000 SNPs were used in an association study using a single-step procedure. The following traits were analyzed: vertical position of hair whorl on the head, number of whorls on the head, and number of whorls on the left and right sides of the neck. The traits had between one and three genomic windows associated. Each of them explained at least 4% of the additive variance. The windows accounted for 20–80% of additive variance for each trait analyzed. Many of the prospected genes are related to hair follicle growth. Some of these genes exert a pleiotropic effect on neurological and behavioral traits. This is the first indication of biological and physiological activity that might explain the association of hair whorls and temperament.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-01
2022-05-01T09:31:03Z
2022-05-01T09:31:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/ani11102925
Animals, v. 11, n. 10, 2021.
2076-2615
http://hdl.handle.net/11449/233631
10.3390/ani11102925
2-s2.0-85116680266
url http://dx.doi.org/10.3390/ani11102925
http://hdl.handle.net/11449/233631
identifier_str_mv Animals, v. 11, n. 10, 2021.
2076-2615
10.3390/ani11102925
2-s2.0-85116680266
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Animals
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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