Anemia falciforme: desafios e avanços na busca de novos fármacos

Detalhes bibliográficos
Autor(a) principal: Santos, Jean Leandro dos [UNESP]
Data de Publicação: 2012
Outros Autores: Chin, Chung Man [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-40422012000400025
http://hdl.handle.net/11449/8033
Resumo: Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.
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spelling Anemia falciforme: desafios e avanços na busca de novos fármacosSickle cell disease: challenges and advances in drug discoverySickle Cell Diseasedrug discoverymolecular modificationSickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação para o Desenvolvimento da UNESP (FUNDUNESP)Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências FarmacêuticasUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências FarmacêuticasSociedade Brasileira de QuímicaUniversidade Estadual Paulista (Unesp)Santos, Jean Leandro dos [UNESP]Chin, Chung Man [UNESP]2014-05-20T13:25:23Z2014-05-20T13:25:23Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article783-790application/pdfhttp://dx.doi.org/10.1590/S0100-40422012000400025Química Nova. Sociedade Brasileira de Química, v. 35, n. 4, p. 783-790, 2012.0100-4042http://hdl.handle.net/11449/803310.1590/S0100-40422012000400025S0100-40422012000400025WOS:000304226400025S0100-40422012000400025.pdf97343336079754130000-0003-4141-0455SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporQuímica Nova0.6460,255info:eu-repo/semantics/openAccess2024-06-24T13:46:11Zoai:repositorio.unesp.br:11449/8033Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:40:01.745740Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Anemia falciforme: desafios e avanços na busca de novos fármacos
Sickle cell disease: challenges and advances in drug discovery
title Anemia falciforme: desafios e avanços na busca de novos fármacos
spellingShingle Anemia falciforme: desafios e avanços na busca de novos fármacos
Santos, Jean Leandro dos [UNESP]
Sickle Cell Disease
drug discovery
molecular modification
title_short Anemia falciforme: desafios e avanços na busca de novos fármacos
title_full Anemia falciforme: desafios e avanços na busca de novos fármacos
title_fullStr Anemia falciforme: desafios e avanços na busca de novos fármacos
title_full_unstemmed Anemia falciforme: desafios e avanços na busca de novos fármacos
title_sort Anemia falciforme: desafios e avanços na busca de novos fármacos
author Santos, Jean Leandro dos [UNESP]
author_facet Santos, Jean Leandro dos [UNESP]
Chin, Chung Man [UNESP]
author_role author
author2 Chin, Chung Man [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Santos, Jean Leandro dos [UNESP]
Chin, Chung Man [UNESP]
dc.subject.por.fl_str_mv Sickle Cell Disease
drug discovery
molecular modification
topic Sickle Cell Disease
drug discovery
molecular modification
description Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
2014-05-20T13:25:23Z
2014-05-20T13:25:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40422012000400025
Química Nova. Sociedade Brasileira de Química, v. 35, n. 4, p. 783-790, 2012.
0100-4042
http://hdl.handle.net/11449/8033
10.1590/S0100-40422012000400025
S0100-40422012000400025
WOS:000304226400025
S0100-40422012000400025.pdf
9734333607975413
0000-0003-4141-0455
url http://dx.doi.org/10.1590/S0100-40422012000400025
http://hdl.handle.net/11449/8033
identifier_str_mv Química Nova. Sociedade Brasileira de Química, v. 35, n. 4, p. 783-790, 2012.
0100-4042
10.1590/S0100-40422012000400025
S0100-40422012000400025
WOS:000304226400025
S0100-40422012000400025.pdf
9734333607975413
0000-0003-4141-0455
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Química Nova
0.646
0,255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 783-790
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129232155443200

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