Anemia falciforme: desafios e avanços na busca de novos fármacos

Detalhes bibliográficos
Autor(a) principal: Santos,Jean Leandro dos
Data de Publicação: 2012
Outros Autores: Chin,Chung Man
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400025
Resumo: Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.
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spelling Anemia falciforme: desafios e avanços na busca de novos fármacosSickle Cell Diseasedrug discoverymolecular modificationSickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400025Química Nova v.35 n.4 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000400025info:eu-repo/semantics/openAccessSantos,Jean Leandro dosChin,Chung Manpor2012-05-25T00:00:00Zoai:scielo:S0100-40422012000400025Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-05-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Anemia falciforme: desafios e avanços na busca de novos fármacos
title Anemia falciforme: desafios e avanços na busca de novos fármacos
spellingShingle Anemia falciforme: desafios e avanços na busca de novos fármacos
Santos,Jean Leandro dos
Sickle Cell Disease
drug discovery
molecular modification
title_short Anemia falciforme: desafios e avanços na busca de novos fármacos
title_full Anemia falciforme: desafios e avanços na busca de novos fármacos
title_fullStr Anemia falciforme: desafios e avanços na busca de novos fármacos
title_full_unstemmed Anemia falciforme: desafios e avanços na busca de novos fármacos
title_sort Anemia falciforme: desafios e avanços na busca de novos fármacos
author Santos,Jean Leandro dos
author_facet Santos,Jean Leandro dos
Chin,Chung Man
author_role author
author2 Chin,Chung Man
author2_role author
dc.contributor.author.fl_str_mv Santos,Jean Leandro dos
Chin,Chung Man
dc.subject.por.fl_str_mv Sickle Cell Disease
drug discovery
molecular modification
topic Sickle Cell Disease
drug discovery
molecular modification
description Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400025
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400025
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000400025
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.4 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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