Apoptose em otorrinolaringologia e cabeça e pescoço

• Autor(a) principal: Drimel Molina, Fernando
• Data de Publicação: 2003
• Outros Autores: Golloni-Bertollo, Eny Maria, Taboga, Sebastião Roberto [UNESP], Maniglia, José Victor
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.moreirajr.com.br/revistas.asp?id_materia=2340&fase=imprime; http://hdl.handle.net/11449/67313
• topic: Apoptosis; Cancer; Head and neck tumors; Otorhinolaringology; Programed cell death; Fas antigen; protein BAD; protein Bax; protein bcl 2; protein bcl x; protein bcl xl; protein p53; Adenovirus; Alzheimer disease; aplastic anemia; apoptosis; autoimmune disease; breast adenoma; carcinogenesis; cell activity; cell function; cell proliferation; cell structure; cell survival; central nervous system; follicular lymphoma; glomerulonephritis; Herpes virus; Herpes virus infection; hormone dependence; human; ischemia; liver disease; medical specialist; molecular dynamics; neoplasm; nonhuman; olfactory nerve disease; otorhinolaryngology; ovary tumor; Parkinson disease; Poxvirus; Poxvirus infection; prostate carcinoma; protein analysis; protein determination; protein function; review; systemic lupus erythematosus; vestibular disorder; virus infection

This paper intend to review recent advances in our understanding of programmed cell death, or apoptosis, and discuss implications of these basic science advances in the development of causes and potential treatments of a variety of diseases of the head and neck. Conclusions: apoptosis is now understood to be important in the normal development and survival of all multicellular organism. Deregulation of this normally tighly controlled process underlies a variety of disease states, including neoplasia, autoimmune disease, and disorders of the central nervous system. A better understanding of this process and regulation may help otolaryngologists better understand diseases relevant to this specialty and will lead to improved therapeutic interventions.