Porosity of temporary denture soft liners containing antifungal agents
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-775720160092 http://hdl.handle.net/11449/162161 |
Resumo: | Incorporation of antifungals in temporary denture soft liners has been recommended for denture stomatitis treatment; however, it may affect their properties. Objective: To evaluate the porosity of a tissue conditioner (Softone) and a temporary resilient liner (Trusoft) modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm. Material and Methods: The porosity was measured by water absorption, based on exclusion of the plasticizer effect. Initially, it was determined by sorption isotherms that the adequate storage solution for specimens (65x10x3.3 mm) of both materials was 50% anhydrous calcium chloride (S50). Then, the porosity factor (PF) was calculated for the study groups (n=10) formed by specimens without (control) or with drug incorporation at MICs (nystatin:Ny-0.032 g, chlorhexidine diacetate: Chx-0.064 g, or ketoconazole: Ke-0.128 g each per gram of soft liner powder) after storage in distilled water or S50 for 24 h, seven and 14 d. Data were statistically analyzed by 4-way repeated measures ANOVA and Tukey's test (alpha=.05). Results: Ke resulted in no significant changes in PF for both liners in water over 14 days (p>0.05). Compared with the controls, Softone and Trusoft PFs were increased at 14-day water immersion only after addition of Ny and Chx, and Chx, respectively (p<0.05). Both materials showed no significant changes in PF in up to 14 days of S50 immersion, compared with the controls (p>0.05). In all experimental conditions, Softone and Trusoft PFs were significantly lower when immersed in S50 compared with distilled water (p<0.05). Conclusions: The addition of antifungals at MICs resulted in no harmful effects for the porosity of both temporary soft liners in different periods of water immersion, except for Chx and Ny in Softone and Chx in Trusoft at 14 days. No deleterious effect was observed for the porosity of both soft liners modified by the drugs at MICs over 14 days of S50 immersion. |
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Porosity of temporary denture soft liners containing antifungal agentsDenture stomatitisDenture linersPorosityAnti-infective agentsIncorporation of antifungals in temporary denture soft liners has been recommended for denture stomatitis treatment; however, it may affect their properties. Objective: To evaluate the porosity of a tissue conditioner (Softone) and a temporary resilient liner (Trusoft) modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm. Material and Methods: The porosity was measured by water absorption, based on exclusion of the plasticizer effect. Initially, it was determined by sorption isotherms that the adequate storage solution for specimens (65x10x3.3 mm) of both materials was 50% anhydrous calcium chloride (S50). Then, the porosity factor (PF) was calculated for the study groups (n=10) formed by specimens without (control) or with drug incorporation at MICs (nystatin:Ny-0.032 g, chlorhexidine diacetate: Chx-0.064 g, or ketoconazole: Ke-0.128 g each per gram of soft liner powder) after storage in distilled water or S50 for 24 h, seven and 14 d. Data were statistically analyzed by 4-way repeated measures ANOVA and Tukey's test (alpha=.05). Results: Ke resulted in no significant changes in PF for both liners in water over 14 days (p>0.05). Compared with the controls, Softone and Trusoft PFs were increased at 14-day water immersion only after addition of Ny and Chx, and Chx, respectively (p<0.05). Both materials showed no significant changes in PF in up to 14 days of S50 immersion, compared with the controls (p>0.05). In all experimental conditions, Softone and Trusoft PFs were significantly lower when immersed in S50 compared with distilled water (p<0.05). Conclusions: The addition of antifungals at MICs resulted in no harmful effects for the porosity of both temporary soft liners in different periods of water immersion, except for Chx and Ny in Softone and Chx in Trusoft at 14 days. No deleterious effect was observed for the porosity of both soft liners modified by the drugs at MICs over 14 days of S50 immersion.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sao Paulo, Fac Odontol Bauru, Dept Protese, Bauru, SP, BrazilUniv Estadual Paulista, Fac Odontol Araraquara, Dept Mat Odontol & Protese, Araraquara, SP, BrazilUniv Sao Paulo, Fac Odontol Bauru, Dept Odontopediat Ortodontia & Saude Colet, Bauru, SP, BrazilUniv Estadual Ponta Grossa, Dept Odontol, Ponta Grossa, PR, BrazilUniv Estadual Paulista, Fac Odontol Araraquara, Dept Mat Odontol & Protese, Araraquara, SP, BrazilFAPESP: 2012/11074-2FAPESP: 2013/10400-6Univ Sao Paulo Fac Odontologia BauruUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Universidade Estadual de Ponta Grossa (UEPG)Mello Lima, Jozely FranciscaMaciel, Janaina GomesHotta, JulianaPero Vizoto, Ana Carolina [UNESP]Honorio, Heitor MarquesUrban, Vanessa MiglioriniNeppelenbroek, Karin Hermana2018-11-26T17:10:38Z2018-11-26T17:10:38Z2016-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article453-461application/pdfhttp://dx.doi.org/10.1590/1678-775720160092Journal Of Applied Oral Science. Bauru-sp: Univ Sao Paulo Fac Odontologia Bauru, v. 24, n. 5, p. 453-461, 2016.1678-7757http://hdl.handle.net/11449/16216110.1590/1678-775720160092S1678-77572016000500453WOS:000387779600006S1678-77572016000500453.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Applied Oral Science0,645info:eu-repo/semantics/openAccess2023-12-03T06:10:38Zoai:repositorio.unesp.br:11449/162161Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:21:06.505953Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Porosity of temporary denture soft liners containing antifungal agents |
title |
Porosity of temporary denture soft liners containing antifungal agents |
spellingShingle |
Porosity of temporary denture soft liners containing antifungal agents Mello Lima, Jozely Francisca Denture stomatitis Denture liners Porosity Anti-infective agents |
title_short |
Porosity of temporary denture soft liners containing antifungal agents |
title_full |
Porosity of temporary denture soft liners containing antifungal agents |
title_fullStr |
Porosity of temporary denture soft liners containing antifungal agents |
title_full_unstemmed |
Porosity of temporary denture soft liners containing antifungal agents |
title_sort |
Porosity of temporary denture soft liners containing antifungal agents |
author |
Mello Lima, Jozely Francisca |
author_facet |
Mello Lima, Jozely Francisca Maciel, Janaina Gomes Hotta, Juliana Pero Vizoto, Ana Carolina [UNESP] Honorio, Heitor Marques Urban, Vanessa Migliorini Neppelenbroek, Karin Hermana |
author_role |
author |
author2 |
Maciel, Janaina Gomes Hotta, Juliana Pero Vizoto, Ana Carolina [UNESP] Honorio, Heitor Marques Urban, Vanessa Migliorini Neppelenbroek, Karin Hermana |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Universidade Estadual de Ponta Grossa (UEPG) |
dc.contributor.author.fl_str_mv |
Mello Lima, Jozely Francisca Maciel, Janaina Gomes Hotta, Juliana Pero Vizoto, Ana Carolina [UNESP] Honorio, Heitor Marques Urban, Vanessa Migliorini Neppelenbroek, Karin Hermana |
dc.subject.por.fl_str_mv |
Denture stomatitis Denture liners Porosity Anti-infective agents |
topic |
Denture stomatitis Denture liners Porosity Anti-infective agents |
description |
Incorporation of antifungals in temporary denture soft liners has been recommended for denture stomatitis treatment; however, it may affect their properties. Objective: To evaluate the porosity of a tissue conditioner (Softone) and a temporary resilient liner (Trusoft) modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm. Material and Methods: The porosity was measured by water absorption, based on exclusion of the plasticizer effect. Initially, it was determined by sorption isotherms that the adequate storage solution for specimens (65x10x3.3 mm) of both materials was 50% anhydrous calcium chloride (S50). Then, the porosity factor (PF) was calculated for the study groups (n=10) formed by specimens without (control) or with drug incorporation at MICs (nystatin:Ny-0.032 g, chlorhexidine diacetate: Chx-0.064 g, or ketoconazole: Ke-0.128 g each per gram of soft liner powder) after storage in distilled water or S50 for 24 h, seven and 14 d. Data were statistically analyzed by 4-way repeated measures ANOVA and Tukey's test (alpha=.05). Results: Ke resulted in no significant changes in PF for both liners in water over 14 days (p>0.05). Compared with the controls, Softone and Trusoft PFs were increased at 14-day water immersion only after addition of Ny and Chx, and Chx, respectively (p<0.05). Both materials showed no significant changes in PF in up to 14 days of S50 immersion, compared with the controls (p>0.05). In all experimental conditions, Softone and Trusoft PFs were significantly lower when immersed in S50 compared with distilled water (p<0.05). Conclusions: The addition of antifungals at MICs resulted in no harmful effects for the porosity of both temporary soft liners in different periods of water immersion, except for Chx and Ny in Softone and Chx in Trusoft at 14 days. No deleterious effect was observed for the porosity of both soft liners modified by the drugs at MICs over 14 days of S50 immersion. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 2018-11-26T17:10:38Z 2018-11-26T17:10:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-775720160092 Journal Of Applied Oral Science. Bauru-sp: Univ Sao Paulo Fac Odontologia Bauru, v. 24, n. 5, p. 453-461, 2016. 1678-7757 http://hdl.handle.net/11449/162161 10.1590/1678-775720160092 S1678-77572016000500453 WOS:000387779600006 S1678-77572016000500453.pdf |
url |
http://dx.doi.org/10.1590/1678-775720160092 http://hdl.handle.net/11449/162161 |
identifier_str_mv |
Journal Of Applied Oral Science. Bauru-sp: Univ Sao Paulo Fac Odontologia Bauru, v. 24, n. 5, p. 453-461, 2016. 1678-7757 10.1590/1678-775720160092 S1678-77572016000500453 WOS:000387779600006 S1678-77572016000500453.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Applied Oral Science 0,645 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
453-461 application/pdf |
dc.publisher.none.fl_str_mv |
Univ Sao Paulo Fac Odontologia Bauru |
publisher.none.fl_str_mv |
Univ Sao Paulo Fac Odontologia Bauru |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129057063174144 |