Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdf http://hdl.handle.net/11449/76243 |
Resumo: | HIOMT is a gene that encodes hydroxyindole-O-methyltransfe-rase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphisms in the HIOMT gene exhibit a possible trend to influence circadian phenotypes in this Brazilian population sample, possibly affecting the rate and/or level of melatonin synthesis. |
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Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianosScreening for polymorphisms in the HIOMT gene and associations with circadian phenotypesCircadian rhythmGenetics behavorialMelatoninPolymorphism geneticHIOMT is a gene that encodes hydroxyindole-O-methyltransfe-rase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphisms in the HIOMT gene exhibit a possible trend to influence circadian phenotypes in this Brazilian population sample, possibly affecting the rate and/or level of melatonin synthesis.Department of Psychobiology Universidade Federal de São Paulo, São PauloDepartment of Genetics Universidade Estadual de São Paulo, BotucatuSchool of Arts, Science and Humanities Universidade de São Paulo, São PauloDepartment of Genetics Universidade Estadual de São Paulo, BotucatuUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Pereira, Danyella SilvaKoike, Bruna Del VechioRibeiro, Amanda de Oliveira [UNESP]Umemura, Guilherme SilvaTufik, SergioNeto, Mario Pedrazzoli2014-05-27T11:30:08Z2014-05-27T11:30:08Z2013-08-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article66-71application/pdfhttp://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdfSleep Science, v. 6, n. 2, p. 66-71, 2013.1984-06591984-0063http://hdl.handle.net/11449/762432-s2.0-848810509642-s2.0-84881050964.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporSleep Science0,5700,570info:eu-repo/semantics/openAccess2023-11-12T06:10:10Zoai:repositorio.unesp.br:11449/76243Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:26:35.287162Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos Screening for polymorphisms in the HIOMT gene and associations with circadian phenotypes |
title |
Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos |
spellingShingle |
Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos Pereira, Danyella Silva Circadian rhythm Genetics behavorial Melatonin Polymorphism genetic |
title_short |
Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos |
title_full |
Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos |
title_fullStr |
Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos |
title_full_unstemmed |
Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos |
title_sort |
Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos |
author |
Pereira, Danyella Silva |
author_facet |
Pereira, Danyella Silva Koike, Bruna Del Vechio Ribeiro, Amanda de Oliveira [UNESP] Umemura, Guilherme Silva Tufik, Sergio Neto, Mario Pedrazzoli |
author_role |
author |
author2 |
Koike, Bruna Del Vechio Ribeiro, Amanda de Oliveira [UNESP] Umemura, Guilherme Silva Tufik, Sergio Neto, Mario Pedrazzoli |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Pereira, Danyella Silva Koike, Bruna Del Vechio Ribeiro, Amanda de Oliveira [UNESP] Umemura, Guilherme Silva Tufik, Sergio Neto, Mario Pedrazzoli |
dc.subject.por.fl_str_mv |
Circadian rhythm Genetics behavorial Melatonin Polymorphism genetic |
topic |
Circadian rhythm Genetics behavorial Melatonin Polymorphism genetic |
description |
HIOMT is a gene that encodes hydroxyindole-O-methyltransfe-rase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphisms in the HIOMT gene exhibit a possible trend to influence circadian phenotypes in this Brazilian population sample, possibly affecting the rate and/or level of melatonin synthesis. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-08-08 2014-05-27T11:30:08Z 2014-05-27T11:30:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdf Sleep Science, v. 6, n. 2, p. 66-71, 2013. 1984-0659 1984-0063 http://hdl.handle.net/11449/76243 2-s2.0-84881050964 2-s2.0-84881050964.pdf |
url |
http://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdf http://hdl.handle.net/11449/76243 |
identifier_str_mv |
Sleep Science, v. 6, n. 2, p. 66-71, 2013. 1984-0659 1984-0063 2-s2.0-84881050964 2-s2.0-84881050964.pdf |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
Sleep Science 0,570 0,570 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
66-71 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128812920078336 |