Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake
Autor(a) principal: | |
---|---|
Data de Publicação: | 2001 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://ajpregu.physiology.org/content/280/5/R1301 http://hdl.handle.net/11449/16076 |
Resumo: | Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, we investigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterally in the LPBN were treated with furosemide + captopril to induce water and NaCl intake. Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 mug) or the CCK antagonist proglumide (50 mug), alone or combined, produced similar increases in water and 1.8% NaCl intake. Low doses of methysergide (0.5 mug) + proglumide (20 mug) produced greater increases in NaCl intake than when they were injected alone. The 5-HT2a/2c agonist 2,5-dimetoxy-4-iodoamphetamine hydrobromide (DOI; 5 mug) into the LPBN reduced water and NaCl intake. After proglumide (50 mug) + DOI treatment, the intake was not different from vehicle treatment. CCK-8 (1 mug) alone produced no effect. CCK-8 combined with methysergide (4 mug) reduced the effect of methysergide on NaCl intake. The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake. |
id |
UNSP_a9b7914ccc9558ff3664512e10f45af3 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/16076 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake5-hydroxytryptamineproglumidemethysergideNaCl intakesodium appetiteangiotensin IISerotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, we investigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterally in the LPBN were treated with furosemide + captopril to induce water and NaCl intake. Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 mug) or the CCK antagonist proglumide (50 mug), alone or combined, produced similar increases in water and 1.8% NaCl intake. Low doses of methysergide (0.5 mug) + proglumide (20 mug) produced greater increases in NaCl intake than when they were injected alone. The 5-HT2a/2c agonist 2,5-dimetoxy-4-iodoamphetamine hydrobromide (DOI; 5 mug) into the LPBN reduced water and NaCl intake. After proglumide (50 mug) + DOI treatment, the intake was not different from vehicle treatment. CCK-8 (1 mug) alone produced no effect. CCK-8 combined with methysergide (4 mug) reduced the effect of methysergide on NaCl intake. The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake.UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, BrazilUniv Iowa, Dept Psychol, Iowa City, IA 52242 USAUniv Iowa, Dept Pharmacol & Exercise Sci, Iowa City, IA 52242 USAUniv Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USAUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, BrazilAmer Physiological SocUniversidade Estadual Paulista (Unesp)Univ IowaDe Gobbi, JIFDe Luca, L. A.Johnson, A. K.Menani, José Vanderlei [UNESP]2014-05-20T13:45:40Z2014-05-20T13:45:40Z2001-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleR1301-R1307http://ajpregu.physiology.org/content/280/5/R1301American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 280, n. 5, p. R1301-R1307, 2001.0363-6119http://hdl.handle.net/11449/16076WOS:0001679734000061023597870118105Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology3.0821,550info:eu-repo/semantics/openAccess2021-10-23T10:49:42Zoai:repositorio.unesp.br:11449/16076Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:04:38.543426Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake |
title |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake |
spellingShingle |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake De Gobbi, JIF 5-hydroxytryptamine proglumide methysergide NaCl intake sodium appetite angiotensin II |
title_short |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake |
title_full |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake |
title_fullStr |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake |
title_full_unstemmed |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake |
title_sort |
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake |
author |
De Gobbi, JIF |
author_facet |
De Gobbi, JIF De Luca, L. A. Johnson, A. K. Menani, José Vanderlei [UNESP] |
author_role |
author |
author2 |
De Luca, L. A. Johnson, A. K. Menani, José Vanderlei [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Iowa |
dc.contributor.author.fl_str_mv |
De Gobbi, JIF De Luca, L. A. Johnson, A. K. Menani, José Vanderlei [UNESP] |
dc.subject.por.fl_str_mv |
5-hydroxytryptamine proglumide methysergide NaCl intake sodium appetite angiotensin II |
topic |
5-hydroxytryptamine proglumide methysergide NaCl intake sodium appetite angiotensin II |
description |
Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, we investigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterally in the LPBN were treated with furosemide + captopril to induce water and NaCl intake. Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 mug) or the CCK antagonist proglumide (50 mug), alone or combined, produced similar increases in water and 1.8% NaCl intake. Low doses of methysergide (0.5 mug) + proglumide (20 mug) produced greater increases in NaCl intake than when they were injected alone. The 5-HT2a/2c agonist 2,5-dimetoxy-4-iodoamphetamine hydrobromide (DOI; 5 mug) into the LPBN reduced water and NaCl intake. After proglumide (50 mug) + DOI treatment, the intake was not different from vehicle treatment. CCK-8 (1 mug) alone produced no effect. CCK-8 combined with methysergide (4 mug) reduced the effect of methysergide on NaCl intake. The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-05-01 2014-05-20T13:45:40Z 2014-05-20T13:45:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://ajpregu.physiology.org/content/280/5/R1301 American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 280, n. 5, p. R1301-R1307, 2001. 0363-6119 http://hdl.handle.net/11449/16076 WOS:000167973400006 1023597870118105 |
url |
http://ajpregu.physiology.org/content/280/5/R1301 http://hdl.handle.net/11449/16076 |
identifier_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 280, n. 5, p. R1301-R1307, 2001. 0363-6119 WOS:000167973400006 1023597870118105 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Physiology: Regulatory Integrative and Comparative Physiology 3.082 1,550 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
R1301-R1307 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128890781040640 |