Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration

Detalhes bibliográficos
Autor(a) principal: Saska, S. [UNESP]
Data de Publicação: 2011
Outros Autores: Barud, H. S. [UNESP], Gaspar, A. M M [UNESP], Marchetto, Reinaldo [UNESP], Ribeiro, Sidney José Lima [UNESP], Messaddeq, Younes [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2011/175362
http://hdl.handle.net/11449/72814
Resumo: The aim of this study was to develop and to evaluate the biological properties of bacterial cellulose-hydroxyapatite (BC-HA) nanocomposite membranes for bone regeneration. Nanocomposites were prepared from bacterial cellulose membranes sequentially incubated in solutions of CaCl2 followed by Na2HPO4. BC-HA membranes were evaluated in noncritical bone defects in rat tibiae at 1, 4, and 16 weeks. Thermogravimetric analyses showed that the amount of the mineral phase was 40-50 of the total weight. Spectroscopy, electronic microscopy/energy dispersive X-ray analyses, and X-ray diffraction showed formation of HA crystals on BC nanofibres. Low crystallinity HA crystals presented Ca/P a molar ratio of 1.5 (calcium-deficient HA), similar to physiological bone. Fourier transformed infrared spectroscopy analysis showed bands assigned to phosphate and carbonate ions. In vivo tests showed no inflammatory reaction after 1 week. After 4 weeks, defects were observed to be completely filled in by new bone tissue. The BC-HA membranes were effective for bone regeneration. © 2011 S. Saska et al.
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spelling Bacterial cellulose-hydroxyapatite nanocomposites for bone regenerationThe aim of this study was to develop and to evaluate the biological properties of bacterial cellulose-hydroxyapatite (BC-HA) nanocomposite membranes for bone regeneration. Nanocomposites were prepared from bacterial cellulose membranes sequentially incubated in solutions of CaCl2 followed by Na2HPO4. BC-HA membranes were evaluated in noncritical bone defects in rat tibiae at 1, 4, and 16 weeks. Thermogravimetric analyses showed that the amount of the mineral phase was 40-50 of the total weight. Spectroscopy, electronic microscopy/energy dispersive X-ray analyses, and X-ray diffraction showed formation of HA crystals on BC nanofibres. Low crystallinity HA crystals presented Ca/P a molar ratio of 1.5 (calcium-deficient HA), similar to physiological bone. Fourier transformed infrared spectroscopy analysis showed bands assigned to phosphate and carbonate ions. In vivo tests showed no inflammatory reaction after 1 week. After 4 weeks, defects were observed to be completely filled in by new bone tissue. The BC-HA membranes were effective for bone regeneration. © 2011 S. Saska et al.Institute of Chemistry University Estadual Paulista-UNESP, CP 355, 14-801-970 Araraquara, SPDepartment of Inorganic Chemistry Institute of ChemistryUNESP, Rua Francisco Degni s/n, 14-800-900 Araraquara, SPDepartment of Morphology Dental School University Estadual Paulista-UNESP, Rua Humaitá 1680, 14-801-903 Araraquara, SPInstitute of Chemistry University Estadual Paulista-UNESP, CP 355, 14-801-970 Araraquara, SPDepartment of Inorganic Chemistry Institute of ChemistryUNESP, Rua Francisco Degni s/n, 14-800-900 Araraquara, SPDepartment of Morphology Dental School University Estadual Paulista-UNESP, Rua Humaitá 1680, 14-801-903 Araraquara, SPUniversidade Estadual Paulista (Unesp)Saska, S. [UNESP]Barud, H. S. [UNESP]Gaspar, A. M M [UNESP]Marchetto, Reinaldo [UNESP]Ribeiro, Sidney José Lima [UNESP]Messaddeq, Younes [UNESP]2014-05-27T11:26:11Z2014-05-27T11:26:11Z2011-11-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2011/175362International Journal of Biomaterials.1687-87871687-8795http://hdl.handle.net/11449/7281410.1155/2011/1753622-s2.0-815552209062-s2.0-81555220906.pdf5711182251641103644604746303465429985038419178150000-0003-3286-9440Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Biomaterials0,5110,511info:eu-repo/semantics/openAccess2024-09-27T15:14:55Zoai:repositorio.unesp.br:11449/72814Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-27T15:14:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration
title Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration
spellingShingle Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration
Saska, S. [UNESP]
title_short Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration
title_full Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration
title_fullStr Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration
title_full_unstemmed Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration
title_sort Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration
author Saska, S. [UNESP]
author_facet Saska, S. [UNESP]
Barud, H. S. [UNESP]
Gaspar, A. M M [UNESP]
Marchetto, Reinaldo [UNESP]
Ribeiro, Sidney José Lima [UNESP]
Messaddeq, Younes [UNESP]
author_role author
author2 Barud, H. S. [UNESP]
Gaspar, A. M M [UNESP]
Marchetto, Reinaldo [UNESP]
Ribeiro, Sidney José Lima [UNESP]
Messaddeq, Younes [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Saska, S. [UNESP]
Barud, H. S. [UNESP]
Gaspar, A. M M [UNESP]
Marchetto, Reinaldo [UNESP]
Ribeiro, Sidney José Lima [UNESP]
Messaddeq, Younes [UNESP]
description The aim of this study was to develop and to evaluate the biological properties of bacterial cellulose-hydroxyapatite (BC-HA) nanocomposite membranes for bone regeneration. Nanocomposites were prepared from bacterial cellulose membranes sequentially incubated in solutions of CaCl2 followed by Na2HPO4. BC-HA membranes were evaluated in noncritical bone defects in rat tibiae at 1, 4, and 16 weeks. Thermogravimetric analyses showed that the amount of the mineral phase was 40-50 of the total weight. Spectroscopy, electronic microscopy/energy dispersive X-ray analyses, and X-ray diffraction showed formation of HA crystals on BC nanofibres. Low crystallinity HA crystals presented Ca/P a molar ratio of 1.5 (calcium-deficient HA), similar to physiological bone. Fourier transformed infrared spectroscopy analysis showed bands assigned to phosphate and carbonate ions. In vivo tests showed no inflammatory reaction after 1 week. After 4 weeks, defects were observed to be completely filled in by new bone tissue. The BC-HA membranes were effective for bone regeneration. © 2011 S. Saska et al.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-24
2014-05-27T11:26:11Z
2014-05-27T11:26:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2011/175362
International Journal of Biomaterials.
1687-8787
1687-8795
http://hdl.handle.net/11449/72814
10.1155/2011/175362
2-s2.0-81555220906
2-s2.0-81555220906.pdf
5711182251641103
6446047463034654
2998503841917815
0000-0003-3286-9440
url http://dx.doi.org/10.1155/2011/175362
http://hdl.handle.net/11449/72814
identifier_str_mv International Journal of Biomaterials.
1687-8787
1687-8795
10.1155/2011/175362
2-s2.0-81555220906
2-s2.0-81555220906.pdf
5711182251641103
6446047463034654
2998503841917815
0000-0003-3286-9440
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Biomaterials
0,511
0,511
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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