Influence of dexamethasone and surfactant in the vitality and lung function of preterm lambs born by cesarean section

• Autor(a) principal: Bovino, F. [UNESP]
• Data de Publicação: 2019
• Outros Autores: Denadai, D. S. [UNESP], ávila, L. G. [UNESP], Deschk, M. [UNESP], Santos, P. S.P. [UNESP], Feitosa, F. L.F. [UNESP], Peiró, J. R. [UNESP], Mendes, L. C.N. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1590/1678-4162-10390
• Texto Completo: http://dx.doi.org/10.1590/1678-4162-10390; http://hdl.handle.net/11449/187567
• topic: Cordeiro; Lambs; Neonatologia; Neonatology; Parâmetros vitais; Vital parameters; Vitalidade; Vitality

The aim of this study was to assess the vitality and lung function of preterm lambs. Twenty seven preterm lambs were divided in four groups. Group I (n=6) preterm lambs/ control; group II (n=9) lambs born to mothers that were treated with dexamethasone antepartum; group III (n=6) lambs treated with surfactant; and group IV (n=6) lambs treated with surfactant and born to mothers that were treated with dexamethasone antepartum. The APGAR score was performed after birth (T 0 ) and 15 minutes later (T 1/4 ) to assess vitality. The vital signs, blood gas analysis, spirometry and capnometry were assessed immediately after birth and continued until 48 hours. Chest radiographs were performed at T 0 , T 24 and T 48 . Significant rectal temperature interactions occurred at T 1 and T 6 depending on the type of treatment used. All animals showed low pH values, which were associated with high pCO 2 values and HCO 3 -values that increased over time from immediately after birth to two days of age. Higher tidal volume values were observed at T 1/4 , T 1 and T 24 when the animals were not treated with surfactant. Capnometry showed significant interactions between treatments at T 0 . Premature animals showed low vitality and impaired pulmonary function.