Endodontic infections increase leukocyte and lymphocyte levels in the blood

Detalhes bibliográficos
Autor(a) principal: Samuel, Renata Oliveira [UNESP]
Data de Publicação: 2018
Outros Autores: Gomes-Filho, João Eduardo [UNESP], Azuma, Mariane Maffei [UNESP], Sumida, Dóris Hissako [UNESP], de Oliveira, Sandra Helena Penha [UNESP], Chiba, Fernando Yamamoto [UNESP], Bomfim, Suely Regina Mogami [UNESP], Ciarlini, Paulo César [UNESP], Narciso, Luis Gustavo [UNESP], Cintra, Luciano Tavares Angelo [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s00784-017-2222-z
http://hdl.handle.net/11449/179277
Resumo: Objectives: The aim of this study was to determine whether the presence of single or multiple apical periodontitis (AP) alters blood cell counts and cytokine production. Material and methods: Thirty rats were divided into three groups: a control group comprising rats without AP, a group called 1AP comprising rats with AP in one tooth, and a group called 4AP comprising rats with AP in four teeth. Endodontic infection was induced by pulp exposure of the first right maxillary molar in the 1AP group or by exposing the first and second right maxillary and mandibular molars in the 4AP group. A blood count and cytokine levels were obtained 30 days after infection by collecting blood by cardiac puncture. The maxillae were dissected and stained with hematoxylin and eosin to evaluate the inflammatory infiltrate. The data were tabulated and subjected to statistical analysis (P < 0.05). Results: Histological analysis showed a predominance of mononuclear inflammatory cells. In blood, significant increase of leukocytes, lymphocytes, and tumor necrosis factor alpha (TNF-α) in 4AP compared with the control and 1AP groups (P < 0.05) was observed. In addition, significant decrease of interleukin-4 (IL-4) in 1AP and 4AP groups compared with the control was observed (P < 0.05). Conclusions: In the rat model, the presence of multiple AP can affect health by increasing lymphocyte and TNF-α levels in the blood. Clinical relevance: The presence of endodontic infections can interfere with the blood profile, altering systemic health.
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spelling Endodontic infections increase leukocyte and lymphocyte levels in the bloodApical periodontitisBlood countLeukocytesLymphocytesObjectives: The aim of this study was to determine whether the presence of single or multiple apical periodontitis (AP) alters blood cell counts and cytokine production. Material and methods: Thirty rats were divided into three groups: a control group comprising rats without AP, a group called 1AP comprising rats with AP in one tooth, and a group called 4AP comprising rats with AP in four teeth. Endodontic infection was induced by pulp exposure of the first right maxillary molar in the 1AP group or by exposing the first and second right maxillary and mandibular molars in the 4AP group. A blood count and cytokine levels were obtained 30 days after infection by collecting blood by cardiac puncture. The maxillae were dissected and stained with hematoxylin and eosin to evaluate the inflammatory infiltrate. The data were tabulated and subjected to statistical analysis (P < 0.05). Results: Histological analysis showed a predominance of mononuclear inflammatory cells. In blood, significant increase of leukocytes, lymphocytes, and tumor necrosis factor alpha (TNF-α) in 4AP compared with the control and 1AP groups (P < 0.05) was observed. In addition, significant decrease of interleukin-4 (IL-4) in 1AP and 4AP groups compared with the control was observed (P < 0.05). Conclusions: In the rat model, the presence of multiple AP can affect health by increasing lymphocyte and TNF-α levels in the blood. Clinical relevance: The presence of endodontic infections can interfere with the blood profile, altering systemic health.Department of Endodontics School of Dentistry São Paulo State University (Unesp), R: José Bonifácio, 1193Department of Clinical Dentistry Dental School UNIUBE—Universidade de UberabaDepartment of Endodontics Ingá University Center UNINGÁ, Rod. PR 317, 6114 - Parque Industrial 200Department of Basic Sciences School of Dentistry São Paulo State University (Unesp)Department of Veterinary Clinical Laboratory School of Veterinary Medicine São Paulo State University (Unesp)Department of Endodontics School of Dentistry São Paulo State University (Unesp), R: José Bonifácio, 1193Department of Basic Sciences School of Dentistry São Paulo State University (Unesp)Department of Veterinary Clinical Laboratory School of Veterinary Medicine São Paulo State University (Unesp)Universidade Estadual Paulista (Unesp)UNIUBE—Universidade de UberabaUNINGÁSamuel, Renata Oliveira [UNESP]Gomes-Filho, João Eduardo [UNESP]Azuma, Mariane Maffei [UNESP]Sumida, Dóris Hissako [UNESP]de Oliveira, Sandra Helena Penha [UNESP]Chiba, Fernando Yamamoto [UNESP]Bomfim, Suely Regina Mogami [UNESP]Ciarlini, Paulo César [UNESP]Narciso, Luis Gustavo [UNESP]Cintra, Luciano Tavares Angelo [UNESP]2018-12-11T17:34:29Z2018-12-11T17:34:29Z2018-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1395-1401application/pdfhttp://dx.doi.org/10.1007/s00784-017-2222-zClinical Oral Investigations, v. 22, n. 3, p. 1395-1401, 2018.1436-37711432-6981http://hdl.handle.net/11449/17927710.1007/s00784-017-2222-z2-s2.0-850311248532-s2.0-85031124853.pdf361394001829950092357430816673620000-0003-1480-5208Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigations0,9860,986info:eu-repo/semantics/openAccess2024-09-19T18:32:10Zoai:repositorio.unesp.br:11449/179277Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:32:10Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Endodontic infections increase leukocyte and lymphocyte levels in the blood
title Endodontic infections increase leukocyte and lymphocyte levels in the blood
spellingShingle Endodontic infections increase leukocyte and lymphocyte levels in the blood
Samuel, Renata Oliveira [UNESP]
Apical periodontitis
Blood count
Leukocytes
Lymphocytes
title_short Endodontic infections increase leukocyte and lymphocyte levels in the blood
title_full Endodontic infections increase leukocyte and lymphocyte levels in the blood
title_fullStr Endodontic infections increase leukocyte and lymphocyte levels in the blood
title_full_unstemmed Endodontic infections increase leukocyte and lymphocyte levels in the blood
title_sort Endodontic infections increase leukocyte and lymphocyte levels in the blood
author Samuel, Renata Oliveira [UNESP]
author_facet Samuel, Renata Oliveira [UNESP]
Gomes-Filho, João Eduardo [UNESP]
Azuma, Mariane Maffei [UNESP]
Sumida, Dóris Hissako [UNESP]
de Oliveira, Sandra Helena Penha [UNESP]
Chiba, Fernando Yamamoto [UNESP]
Bomfim, Suely Regina Mogami [UNESP]
Ciarlini, Paulo César [UNESP]
Narciso, Luis Gustavo [UNESP]
Cintra, Luciano Tavares Angelo [UNESP]
author_role author
author2 Gomes-Filho, João Eduardo [UNESP]
Azuma, Mariane Maffei [UNESP]
Sumida, Dóris Hissako [UNESP]
de Oliveira, Sandra Helena Penha [UNESP]
Chiba, Fernando Yamamoto [UNESP]
Bomfim, Suely Regina Mogami [UNESP]
Ciarlini, Paulo César [UNESP]
Narciso, Luis Gustavo [UNESP]
Cintra, Luciano Tavares Angelo [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
UNIUBE—Universidade de Uberaba
UNINGÁ
dc.contributor.author.fl_str_mv Samuel, Renata Oliveira [UNESP]
Gomes-Filho, João Eduardo [UNESP]
Azuma, Mariane Maffei [UNESP]
Sumida, Dóris Hissako [UNESP]
de Oliveira, Sandra Helena Penha [UNESP]
Chiba, Fernando Yamamoto [UNESP]
Bomfim, Suely Regina Mogami [UNESP]
Ciarlini, Paulo César [UNESP]
Narciso, Luis Gustavo [UNESP]
Cintra, Luciano Tavares Angelo [UNESP]
dc.subject.por.fl_str_mv Apical periodontitis
Blood count
Leukocytes
Lymphocytes
topic Apical periodontitis
Blood count
Leukocytes
Lymphocytes
description Objectives: The aim of this study was to determine whether the presence of single or multiple apical periodontitis (AP) alters blood cell counts and cytokine production. Material and methods: Thirty rats were divided into three groups: a control group comprising rats without AP, a group called 1AP comprising rats with AP in one tooth, and a group called 4AP comprising rats with AP in four teeth. Endodontic infection was induced by pulp exposure of the first right maxillary molar in the 1AP group or by exposing the first and second right maxillary and mandibular molars in the 4AP group. A blood count and cytokine levels were obtained 30 days after infection by collecting blood by cardiac puncture. The maxillae were dissected and stained with hematoxylin and eosin to evaluate the inflammatory infiltrate. The data were tabulated and subjected to statistical analysis (P < 0.05). Results: Histological analysis showed a predominance of mononuclear inflammatory cells. In blood, significant increase of leukocytes, lymphocytes, and tumor necrosis factor alpha (TNF-α) in 4AP compared with the control and 1AP groups (P < 0.05) was observed. In addition, significant decrease of interleukin-4 (IL-4) in 1AP and 4AP groups compared with the control was observed (P < 0.05). Conclusions: In the rat model, the presence of multiple AP can affect health by increasing lymphocyte and TNF-α levels in the blood. Clinical relevance: The presence of endodontic infections can interfere with the blood profile, altering systemic health.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:34:29Z
2018-12-11T17:34:29Z
2018-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s00784-017-2222-z
Clinical Oral Investigations, v. 22, n. 3, p. 1395-1401, 2018.
1436-3771
1432-6981
http://hdl.handle.net/11449/179277
10.1007/s00784-017-2222-z
2-s2.0-85031124853
2-s2.0-85031124853.pdf
3613940018299500
9235743081667362
0000-0003-1480-5208
url http://dx.doi.org/10.1007/s00784-017-2222-z
http://hdl.handle.net/11449/179277
identifier_str_mv Clinical Oral Investigations, v. 22, n. 3, p. 1395-1401, 2018.
1436-3771
1432-6981
10.1007/s00784-017-2222-z
2-s2.0-85031124853
2-s2.0-85031124853.pdf
3613940018299500
9235743081667362
0000-0003-1480-5208
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Oral Investigations
0,986
0,986
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1395-1401
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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