Endodontic infections increase leukocyte and lymphocyte levels in the blood
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00784-017-2222-z http://hdl.handle.net/11449/179277 |
Resumo: | Objectives: The aim of this study was to determine whether the presence of single or multiple apical periodontitis (AP) alters blood cell counts and cytokine production. Material and methods: Thirty rats were divided into three groups: a control group comprising rats without AP, a group called 1AP comprising rats with AP in one tooth, and a group called 4AP comprising rats with AP in four teeth. Endodontic infection was induced by pulp exposure of the first right maxillary molar in the 1AP group or by exposing the first and second right maxillary and mandibular molars in the 4AP group. A blood count and cytokine levels were obtained 30 days after infection by collecting blood by cardiac puncture. The maxillae were dissected and stained with hematoxylin and eosin to evaluate the inflammatory infiltrate. The data were tabulated and subjected to statistical analysis (P < 0.05). Results: Histological analysis showed a predominance of mononuclear inflammatory cells. In blood, significant increase of leukocytes, lymphocytes, and tumor necrosis factor alpha (TNF-α) in 4AP compared with the control and 1AP groups (P < 0.05) was observed. In addition, significant decrease of interleukin-4 (IL-4) in 1AP and 4AP groups compared with the control was observed (P < 0.05). Conclusions: In the rat model, the presence of multiple AP can affect health by increasing lymphocyte and TNF-α levels in the blood. Clinical relevance: The presence of endodontic infections can interfere with the blood profile, altering systemic health. |
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Endodontic infections increase leukocyte and lymphocyte levels in the bloodApical periodontitisBlood countLeukocytesLymphocytesObjectives: The aim of this study was to determine whether the presence of single or multiple apical periodontitis (AP) alters blood cell counts and cytokine production. Material and methods: Thirty rats were divided into three groups: a control group comprising rats without AP, a group called 1AP comprising rats with AP in one tooth, and a group called 4AP comprising rats with AP in four teeth. Endodontic infection was induced by pulp exposure of the first right maxillary molar in the 1AP group or by exposing the first and second right maxillary and mandibular molars in the 4AP group. A blood count and cytokine levels were obtained 30 days after infection by collecting blood by cardiac puncture. The maxillae were dissected and stained with hematoxylin and eosin to evaluate the inflammatory infiltrate. The data were tabulated and subjected to statistical analysis (P < 0.05). Results: Histological analysis showed a predominance of mononuclear inflammatory cells. In blood, significant increase of leukocytes, lymphocytes, and tumor necrosis factor alpha (TNF-α) in 4AP compared with the control and 1AP groups (P < 0.05) was observed. In addition, significant decrease of interleukin-4 (IL-4) in 1AP and 4AP groups compared with the control was observed (P < 0.05). Conclusions: In the rat model, the presence of multiple AP can affect health by increasing lymphocyte and TNF-α levels in the blood. Clinical relevance: The presence of endodontic infections can interfere with the blood profile, altering systemic health.Department of Endodontics School of Dentistry São Paulo State University (Unesp), R: José Bonifácio, 1193Department of Clinical Dentistry Dental School UNIUBE—Universidade de UberabaDepartment of Endodontics Ingá University Center UNINGÁ, Rod. PR 317, 6114 - Parque Industrial 200Department of Basic Sciences School of Dentistry São Paulo State University (Unesp)Department of Veterinary Clinical Laboratory School of Veterinary Medicine São Paulo State University (Unesp)Department of Endodontics School of Dentistry São Paulo State University (Unesp), R: José Bonifácio, 1193Department of Basic Sciences School of Dentistry São Paulo State University (Unesp)Department of Veterinary Clinical Laboratory School of Veterinary Medicine São Paulo State University (Unesp)Universidade Estadual Paulista (Unesp)UNIUBE—Universidade de UberabaUNINGÁSamuel, Renata Oliveira [UNESP]Gomes-Filho, João Eduardo [UNESP]Azuma, Mariane Maffei [UNESP]Sumida, Dóris Hissako [UNESP]de Oliveira, Sandra Helena Penha [UNESP]Chiba, Fernando Yamamoto [UNESP]Bomfim, Suely Regina Mogami [UNESP]Ciarlini, Paulo César [UNESP]Narciso, Luis Gustavo [UNESP]Cintra, Luciano Tavares Angelo [UNESP]2018-12-11T17:34:29Z2018-12-11T17:34:29Z2018-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1395-1401application/pdfhttp://dx.doi.org/10.1007/s00784-017-2222-zClinical Oral Investigations, v. 22, n. 3, p. 1395-1401, 2018.1436-37711432-6981http://hdl.handle.net/11449/17927710.1007/s00784-017-2222-z2-s2.0-850311248532-s2.0-85031124853.pdf361394001829950092357430816673620000-0003-1480-5208Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigations0,9860,986info:eu-repo/semantics/openAccess2024-09-19T18:32:10Zoai:repositorio.unesp.br:11449/179277Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:32:10Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Endodontic infections increase leukocyte and lymphocyte levels in the blood |
title |
Endodontic infections increase leukocyte and lymphocyte levels in the blood |
spellingShingle |
Endodontic infections increase leukocyte and lymphocyte levels in the blood Samuel, Renata Oliveira [UNESP] Apical periodontitis Blood count Leukocytes Lymphocytes |
title_short |
Endodontic infections increase leukocyte and lymphocyte levels in the blood |
title_full |
Endodontic infections increase leukocyte and lymphocyte levels in the blood |
title_fullStr |
Endodontic infections increase leukocyte and lymphocyte levels in the blood |
title_full_unstemmed |
Endodontic infections increase leukocyte and lymphocyte levels in the blood |
title_sort |
Endodontic infections increase leukocyte and lymphocyte levels in the blood |
author |
Samuel, Renata Oliveira [UNESP] |
author_facet |
Samuel, Renata Oliveira [UNESP] Gomes-Filho, João Eduardo [UNESP] Azuma, Mariane Maffei [UNESP] Sumida, Dóris Hissako [UNESP] de Oliveira, Sandra Helena Penha [UNESP] Chiba, Fernando Yamamoto [UNESP] Bomfim, Suely Regina Mogami [UNESP] Ciarlini, Paulo César [UNESP] Narciso, Luis Gustavo [UNESP] Cintra, Luciano Tavares Angelo [UNESP] |
author_role |
author |
author2 |
Gomes-Filho, João Eduardo [UNESP] Azuma, Mariane Maffei [UNESP] Sumida, Dóris Hissako [UNESP] de Oliveira, Sandra Helena Penha [UNESP] Chiba, Fernando Yamamoto [UNESP] Bomfim, Suely Regina Mogami [UNESP] Ciarlini, Paulo César [UNESP] Narciso, Luis Gustavo [UNESP] Cintra, Luciano Tavares Angelo [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) UNIUBE—Universidade de Uberaba UNINGÁ |
dc.contributor.author.fl_str_mv |
Samuel, Renata Oliveira [UNESP] Gomes-Filho, João Eduardo [UNESP] Azuma, Mariane Maffei [UNESP] Sumida, Dóris Hissako [UNESP] de Oliveira, Sandra Helena Penha [UNESP] Chiba, Fernando Yamamoto [UNESP] Bomfim, Suely Regina Mogami [UNESP] Ciarlini, Paulo César [UNESP] Narciso, Luis Gustavo [UNESP] Cintra, Luciano Tavares Angelo [UNESP] |
dc.subject.por.fl_str_mv |
Apical periodontitis Blood count Leukocytes Lymphocytes |
topic |
Apical periodontitis Blood count Leukocytes Lymphocytes |
description |
Objectives: The aim of this study was to determine whether the presence of single or multiple apical periodontitis (AP) alters blood cell counts and cytokine production. Material and methods: Thirty rats were divided into three groups: a control group comprising rats without AP, a group called 1AP comprising rats with AP in one tooth, and a group called 4AP comprising rats with AP in four teeth. Endodontic infection was induced by pulp exposure of the first right maxillary molar in the 1AP group or by exposing the first and second right maxillary and mandibular molars in the 4AP group. A blood count and cytokine levels were obtained 30 days after infection by collecting blood by cardiac puncture. The maxillae were dissected and stained with hematoxylin and eosin to evaluate the inflammatory infiltrate. The data were tabulated and subjected to statistical analysis (P < 0.05). Results: Histological analysis showed a predominance of mononuclear inflammatory cells. In blood, significant increase of leukocytes, lymphocytes, and tumor necrosis factor alpha (TNF-α) in 4AP compared with the control and 1AP groups (P < 0.05) was observed. In addition, significant decrease of interleukin-4 (IL-4) in 1AP and 4AP groups compared with the control was observed (P < 0.05). Conclusions: In the rat model, the presence of multiple AP can affect health by increasing lymphocyte and TNF-α levels in the blood. Clinical relevance: The presence of endodontic infections can interfere with the blood profile, altering systemic health. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:34:29Z 2018-12-11T17:34:29Z 2018-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00784-017-2222-z Clinical Oral Investigations, v. 22, n. 3, p. 1395-1401, 2018. 1436-3771 1432-6981 http://hdl.handle.net/11449/179277 10.1007/s00784-017-2222-z 2-s2.0-85031124853 2-s2.0-85031124853.pdf 3613940018299500 9235743081667362 0000-0003-1480-5208 |
url |
http://dx.doi.org/10.1007/s00784-017-2222-z http://hdl.handle.net/11449/179277 |
identifier_str_mv |
Clinical Oral Investigations, v. 22, n. 3, p. 1395-1401, 2018. 1436-3771 1432-6981 10.1007/s00784-017-2222-z 2-s2.0-85031124853 2-s2.0-85031124853.pdf 3613940018299500 9235743081667362 0000-0003-1480-5208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Oral Investigations 0,986 0,986 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1395-1401 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546537611952128 |