Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity

• Autor(a) principal: Higuchi, Célio Takashi [UNESP]
• Data de Publicação: 2011
• Outros Autores: Sannomiya, M. [UNESP], Pavan, Fernando Rogério [UNESP], Leite, S. R. A. [UNESP], Sato, D. N., Franzblau, S. G., Sacramento, Luis Vitor Silva do [UNESP], Vilegas, Wagner [UNESP], Leite, Clarice Queico Fujimura [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1093/ecam/nen077; http://hdl.handle.net/11449/7499

Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 mu g mL(-1)), triterpenoids as bassic acid (MIC = 2.5 mu g mL(-1)), alpha-amyrin acetate (MIC = 62.5 mu g mL(-1)), a mixture of lupeol, alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)) and a mixture of lupeol, and acetates of alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).