Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0103-50532010001000021 http://hdl.handle.net/11449/207 |
Resumo: | The aim of this study was to determine the pharmacokinetic parameters of liposomal ropivacaine after dental anesthesia in 14 healthy volunteers. In this randomized, double-blind and crossover study, the volunteers received maxillary infiltration of liposome-encapsulated 0.5% ropivacaine and, 0.5% ropivacaine with 1:200,000 epinephrine in two different sessions. Blood samples were collected before and after (from 15 to 1440 min) the administration of either ropivacaine formulation. HPLC with UV detection was used to quantify plasma ropivacaine concentrations. The pharmacokinetic parameters AUC(0-24) (area under the plasma concentration x time curve from baseline to 24 h), AUC(0-infinity) (area under the plasma concentration-time curve from baseline to infinity), C-max (maximum drug concentration), CL (renal clearance), T-max (maximum drug concentration time), t(1/2) (elimination half-life) and Vd (volume of distribution) were analyzed using the Wilcoxon signed-rank test. No differences (p > 0.05) were observed between both formulations for any of the pharmacokinetic parameters evaluated and plasma ropivacaine concentrations, considering each period of time. Both formulations showed similar pharmacokinetic profiles, indicating that the liposomal formulation could be a safer option for use of this local anesthetic, due to the absence of a vasoconstrictor. |
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Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesiaropivacainelocal anesthesiadentistryliposomepharmacokineticThe aim of this study was to determine the pharmacokinetic parameters of liposomal ropivacaine after dental anesthesia in 14 healthy volunteers. In this randomized, double-blind and crossover study, the volunteers received maxillary infiltration of liposome-encapsulated 0.5% ropivacaine and, 0.5% ropivacaine with 1:200,000 epinephrine in two different sessions. Blood samples were collected before and after (from 15 to 1440 min) the administration of either ropivacaine formulation. HPLC with UV detection was used to quantify plasma ropivacaine concentrations. The pharmacokinetic parameters AUC(0-24) (area under the plasma concentration x time curve from baseline to 24 h), AUC(0-infinity) (area under the plasma concentration-time curve from baseline to infinity), C-max (maximum drug concentration), CL (renal clearance), T-max (maximum drug concentration time), t(1/2) (elimination half-life) and Vd (volume of distribution) were analyzed using the Wilcoxon signed-rank test. No differences (p > 0.05) were observed between both formulations for any of the pharmacokinetic parameters evaluated and plasma ropivacaine concentrations, considering each period of time. Both formulations showed similar pharmacokinetic profiles, indicating that the liposomal formulation could be a safer option for use of this local anesthetic, due to the absence of a vasoconstrictor.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Campinas, SP, BrazilUniv Estadual Campinas, Inst Biol, Dept Biochem, Campinas, SP, BrazilJulio de Mesquita Filho State Univ, Dept Environm Engn, Sorocaba, SP, BrazilJulio de Mesquita Filho State Univ, Dept Environm Engn, Sorocaba, SP, BrazilFAPESP: 06/00121-9FAPESP: 06/53255-2Soc Brasileira QuimicaUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Franz-Montan, MichelleBergamaschi, Cristiane de Cassiade Paula, EneidaGroppo, Francisco C.Ranali, JoseFraceto, Leonardo Fernandes [UNESP]Volpato, Maria C.2014-05-20T13:12:13Z2014-05-20T13:12:13Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1945-1951http://dx.doi.org/10.1590/S0103-50532010001000021Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 10, p. 1945-1951, 2010.0103-5053http://hdl.handle.net/11449/20710.1590/S0103-50532010001000021S0103-50532010001000021WOS:000282709800020S0103-50532010001000021.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,357info:eu-repo/semantics/openAccess2021-10-23T17:16:48Zoai:repositorio.unesp.br:11449/207Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:39:50.257091Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia |
title |
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia |
spellingShingle |
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia Franz-Montan, Michelle ropivacaine local anesthesia dentistry liposome pharmacokinetic |
title_short |
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia |
title_full |
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia |
title_fullStr |
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia |
title_full_unstemmed |
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia |
title_sort |
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia |
author |
Franz-Montan, Michelle |
author_facet |
Franz-Montan, Michelle Bergamaschi, Cristiane de Cassia de Paula, Eneida Groppo, Francisco C. Ranali, Jose Fraceto, Leonardo Fernandes [UNESP] Volpato, Maria C. |
author_role |
author |
author2 |
Bergamaschi, Cristiane de Cassia de Paula, Eneida Groppo, Francisco C. Ranali, Jose Fraceto, Leonardo Fernandes [UNESP] Volpato, Maria C. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Franz-Montan, Michelle Bergamaschi, Cristiane de Cassia de Paula, Eneida Groppo, Francisco C. Ranali, Jose Fraceto, Leonardo Fernandes [UNESP] Volpato, Maria C. |
dc.subject.por.fl_str_mv |
ropivacaine local anesthesia dentistry liposome pharmacokinetic |
topic |
ropivacaine local anesthesia dentistry liposome pharmacokinetic |
description |
The aim of this study was to determine the pharmacokinetic parameters of liposomal ropivacaine after dental anesthesia in 14 healthy volunteers. In this randomized, double-blind and crossover study, the volunteers received maxillary infiltration of liposome-encapsulated 0.5% ropivacaine and, 0.5% ropivacaine with 1:200,000 epinephrine in two different sessions. Blood samples were collected before and after (from 15 to 1440 min) the administration of either ropivacaine formulation. HPLC with UV detection was used to quantify plasma ropivacaine concentrations. The pharmacokinetic parameters AUC(0-24) (area under the plasma concentration x time curve from baseline to 24 h), AUC(0-infinity) (area under the plasma concentration-time curve from baseline to infinity), C-max (maximum drug concentration), CL (renal clearance), T-max (maximum drug concentration time), t(1/2) (elimination half-life) and Vd (volume of distribution) were analyzed using the Wilcoxon signed-rank test. No differences (p > 0.05) were observed between both formulations for any of the pharmacokinetic parameters evaluated and plasma ropivacaine concentrations, considering each period of time. Both formulations showed similar pharmacokinetic profiles, indicating that the liposomal formulation could be a safer option for use of this local anesthetic, due to the absence of a vasoconstrictor. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2014-05-20T13:12:13Z 2014-05-20T13:12:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0103-50532010001000021 Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 10, p. 1945-1951, 2010. 0103-5053 http://hdl.handle.net/11449/207 10.1590/S0103-50532010001000021 S0103-50532010001000021 WOS:000282709800020 S0103-50532010001000021.pdf |
url |
http://dx.doi.org/10.1590/S0103-50532010001000021 http://hdl.handle.net/11449/207 |
identifier_str_mv |
Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 10, p. 1945-1951, 2010. 0103-5053 10.1590/S0103-50532010001000021 S0103-50532010001000021 WOS:000282709800020 S0103-50532010001000021.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society 1.444 0,357 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1945-1951 |
dc.publisher.none.fl_str_mv |
Soc Brasileira Quimica |
publisher.none.fl_str_mv |
Soc Brasileira Quimica |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129103903064064 |