Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1746-6148-6-45 http://hdl.handle.net/11449/13775 |
Resumo: | Backgroud: Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage plus megakaryocytes in extramedullary sites like liver, spleen and lymph nodes and is usually associated with either bone marrow or hematological disorders. Mammary EMH is a rare condition either in human and veterinary medicine and can be associated with benign mixed mammary tumors, similarly to that described in this case.Case presentation: Hematopoietic stem cells were found in a benign mixed mammary tumor of a 7-year-old female mongrel dog that presents a nodule in the left inguinal mammary gland. The patient did not have any hematological abnormalities. Cytological evaluation demonstrated two distinct cell populations, composed of either epithelial or mesenchymal cells, sometimes associated with a fibrillar acidophilic matrix, apart from megakaryocytes, osteoclasts, metarubricytes, prorubricytes, rubricytes, rubriblasts, promyelocytes, myeloblasts. Histological examination confirmed the presence of an active hematopoietic bone marrow within the bone tissue of a benign mammary mixed tumor.Conclusions: EMH is a rare condition described in veterinary medicine that can be associated with mammary mixed tumors. It's detection can be associated with several neoplastic and non-neoplastic mammary lesions, i.e. osteosarcomas, mixed tumors and bone metaplasia. |
id |
UNSP_accade5fff92e7a555cb86d75ba21f56 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/13775 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessmentBackgroud: Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage plus megakaryocytes in extramedullary sites like liver, spleen and lymph nodes and is usually associated with either bone marrow or hematological disorders. Mammary EMH is a rare condition either in human and veterinary medicine and can be associated with benign mixed mammary tumors, similarly to that described in this case.Case presentation: Hematopoietic stem cells were found in a benign mixed mammary tumor of a 7-year-old female mongrel dog that presents a nodule in the left inguinal mammary gland. The patient did not have any hematological abnormalities. Cytological evaluation demonstrated two distinct cell populations, composed of either epithelial or mesenchymal cells, sometimes associated with a fibrillar acidophilic matrix, apart from megakaryocytes, osteoclasts, metarubricytes, prorubricytes, rubricytes, rubriblasts, promyelocytes, myeloblasts. Histological examination confirmed the presence of an active hematopoietic bone marrow within the bone tissue of a benign mammary mixed tumor.Conclusions: EMH is a rare condition described in veterinary medicine that can be associated with mammary mixed tumors. It's detection can be associated with several neoplastic and non-neoplastic mammary lesions, i.e. osteosarcomas, mixed tumors and bone metaplasia.Univ Estadual Paulista UNESP, Sch Vet Med & Anim Sci FMVZ, Dept Clin Vet Med, São Paulo, BrazilUniv Estadual Paulista UNESP, Sch Vet Med & Anim Sci FMVZ, Dept Anim Reprod & Vet Radiol FMVZ, São Paulo, BrazilUniv Estadual Paulista UNESP, Sch Vet Med & Anim Sci FMVZ, Dept Clin Vet Med, São Paulo, BrazilUniv Estadual Paulista UNESP, Sch Vet Med & Anim Sci FMVZ, Dept Anim Reprod & Vet Radiol FMVZ, São Paulo, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Grandi, Fabrizio [UNESP]Colodel, Marcia M. [UNESP]Monteiro, Lidianne N. [UNESP]Leao, Joao Rafael V. P. [UNESP]Rocha, Noeme Sousa [UNESP]2014-05-20T13:39:41Z2014-05-20T13:39:41Z2010-09-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://dx.doi.org/10.1186/1746-6148-6-45Bmc Veterinary Research. London: Biomed Central Ltd., v. 6, p. 6, 2010.1746-6148http://hdl.handle.net/11449/1377510.1186/1746-6148-6-45WOS:000282897800001WOS000282897800001.pdf60777359184692840000-0002-8188-8149Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Veterinary Research1.9580,934info:eu-repo/semantics/openAccess2024-09-09T14:06:04Zoai:repositorio.unesp.br:11449/13775Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:06:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment |
title |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment |
spellingShingle |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment Grandi, Fabrizio [UNESP] |
title_short |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment |
title_full |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment |
title_fullStr |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment |
title_full_unstemmed |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment |
title_sort |
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment |
author |
Grandi, Fabrizio [UNESP] |
author_facet |
Grandi, Fabrizio [UNESP] Colodel, Marcia M. [UNESP] Monteiro, Lidianne N. [UNESP] Leao, Joao Rafael V. P. [UNESP] Rocha, Noeme Sousa [UNESP] |
author_role |
author |
author2 |
Colodel, Marcia M. [UNESP] Monteiro, Lidianne N. [UNESP] Leao, Joao Rafael V. P. [UNESP] Rocha, Noeme Sousa [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Grandi, Fabrizio [UNESP] Colodel, Marcia M. [UNESP] Monteiro, Lidianne N. [UNESP] Leao, Joao Rafael V. P. [UNESP] Rocha, Noeme Sousa [UNESP] |
description |
Backgroud: Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage plus megakaryocytes in extramedullary sites like liver, spleen and lymph nodes and is usually associated with either bone marrow or hematological disorders. Mammary EMH is a rare condition either in human and veterinary medicine and can be associated with benign mixed mammary tumors, similarly to that described in this case.Case presentation: Hematopoietic stem cells were found in a benign mixed mammary tumor of a 7-year-old female mongrel dog that presents a nodule in the left inguinal mammary gland. The patient did not have any hematological abnormalities. Cytological evaluation demonstrated two distinct cell populations, composed of either epithelial or mesenchymal cells, sometimes associated with a fibrillar acidophilic matrix, apart from megakaryocytes, osteoclasts, metarubricytes, prorubricytes, rubricytes, rubriblasts, promyelocytes, myeloblasts. Histological examination confirmed the presence of an active hematopoietic bone marrow within the bone tissue of a benign mammary mixed tumor.Conclusions: EMH is a rare condition described in veterinary medicine that can be associated with mammary mixed tumors. It's detection can be associated with several neoplastic and non-neoplastic mammary lesions, i.e. osteosarcomas, mixed tumors and bone metaplasia. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-09-16 2014-05-20T13:39:41Z 2014-05-20T13:39:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1746-6148-6-45 Bmc Veterinary Research. London: Biomed Central Ltd., v. 6, p. 6, 2010. 1746-6148 http://hdl.handle.net/11449/13775 10.1186/1746-6148-6-45 WOS:000282897800001 WOS000282897800001.pdf 6077735918469284 0000-0002-8188-8149 |
url |
http://dx.doi.org/10.1186/1746-6148-6-45 http://hdl.handle.net/11449/13775 |
identifier_str_mv |
Bmc Veterinary Research. London: Biomed Central Ltd., v. 6, p. 6, 2010. 1746-6148 10.1186/1746-6148-6-45 WOS:000282897800001 WOS000282897800001.pdf 6077735918469284 0000-0002-8188-8149 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Veterinary Research 1.958 0,934 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021345775321088 |