Importance of bacterial endotoxin (LPS) in endodontics

Detalhes bibliográficos
Autor(a) principal: Leonardo, Mario Roberto [UNESP]
Data de Publicação: 2004
Outros Autores: Silva, Raquel Assed Bezerra Da, Assed, Sada, Nelson-filho, Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-77572004000200002
http://hdl.handle.net/11449/211804
Resumo: New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion.
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spelling Importance of bacterial endotoxin (LPS) in endodonticsA importância da endotoxina bacteriana (LPS) na endodontia atualBacterial endotoxin (LPS)Gram-negative bacteriaCalcium hydroxideEndotoxina bacterianaGram-negativosHidróxido de cálcioNew knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion.O conhecimento mais aprofundado sobre a estrutura e atividade biológica das endotoxinas (LPS) revolucionou os conceitos sobre seu mecanismo de ação e formas de inativação. A partir da década de 80, os avanços tecnológicos na cultura e identificação microbiológica demonstraram que, em canais radiculares de dentes portadores de necrose pulpar e lesão periapical crônica, visível radiograficamente, predominam microrganismos anaeróbios, particularmente os gram-negativos. Como se sabe, os microrganismos gram-negativos, além de possuírem diferentes fatores de virulência e gerarem produtos e sub-produtos tóxicos aos tecidos apicais e periapicais, contêm endotoxina em sua parede celular. Esse conhecimento é particularmente importante, uma vez que a endotoxina é liberada durante a multiplicação ou morte bacteriana, exercendo uma série de efeitos biológicos relevantes, que conduzem a uma reação inflamatória e à reabsorção dos tecidos mineralizados. Tendo em vista o papel da endotoxina na patogênese das lesões periapicais, os autores realizaram uma revisão da literatura específica, abordando suas atividades biológicas e a importância de sua inativação durante o tratamento de dentes portadores de necrose pulpar e lesão periapical.Universidade de São Paulo, of Dentistry of Ribeirão PretoUniversidade Estadual Paulista, School of Dentistry of AraraquaraUniversidade Estadual Paulista, School of Dentistry of AraraquaraFaculdade De Odontologia De Bauru - USPUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Leonardo, Mario Roberto [UNESP]Silva, Raquel Assed Bezerra DaAssed, SadaNelson-filho, Paulo2021-07-14T10:29:55Z2021-07-14T10:29:55Z2004-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article93-98application/pdfhttp://dx.doi.org/10.1590/S1678-77572004000200002Journal of Applied Oral Science. Bauru, SP, Brazil: Faculdade De Odontologia De Bauru - USP, v. 12, n. 2, p. 93-98, 2004.1678-77571678-7765http://hdl.handle.net/11449/21180410.1590/S1678-77572004000200002S1678-77572004000200002S1678-77572004000200002.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccess2023-11-27T06:15:05Zoai:repositorio.unesp.br:11449/211804Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:52:06.984104Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Importance of bacterial endotoxin (LPS) in endodontics
A importância da endotoxina bacteriana (LPS) na endodontia atual
title Importance of bacterial endotoxin (LPS) in endodontics
spellingShingle Importance of bacterial endotoxin (LPS) in endodontics
Leonardo, Mario Roberto [UNESP]
Bacterial endotoxin (LPS)
Gram-negative bacteria
Calcium hydroxide
Endotoxina bacteriana
Gram-negativos
Hidróxido de cálcio
title_short Importance of bacterial endotoxin (LPS) in endodontics
title_full Importance of bacterial endotoxin (LPS) in endodontics
title_fullStr Importance of bacterial endotoxin (LPS) in endodontics
title_full_unstemmed Importance of bacterial endotoxin (LPS) in endodontics
title_sort Importance of bacterial endotoxin (LPS) in endodontics
author Leonardo, Mario Roberto [UNESP]
author_facet Leonardo, Mario Roberto [UNESP]
Silva, Raquel Assed Bezerra Da
Assed, Sada
Nelson-filho, Paulo
author_role author
author2 Silva, Raquel Assed Bezerra Da
Assed, Sada
Nelson-filho, Paulo
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Leonardo, Mario Roberto [UNESP]
Silva, Raquel Assed Bezerra Da
Assed, Sada
Nelson-filho, Paulo
dc.subject.por.fl_str_mv Bacterial endotoxin (LPS)
Gram-negative bacteria
Calcium hydroxide
Endotoxina bacteriana
Gram-negativos
Hidróxido de cálcio
topic Bacterial endotoxin (LPS)
Gram-negative bacteria
Calcium hydroxide
Endotoxina bacteriana
Gram-negativos
Hidróxido de cálcio
description New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion.
publishDate 2004
dc.date.none.fl_str_mv 2004-06
2021-07-14T10:29:55Z
2021-07-14T10:29:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-77572004000200002
Journal of Applied Oral Science. Bauru, SP, Brazil: Faculdade De Odontologia De Bauru - USP, v. 12, n. 2, p. 93-98, 2004.
1678-7757
1678-7765
http://hdl.handle.net/11449/211804
10.1590/S1678-77572004000200002
S1678-77572004000200002
S1678-77572004000200002.pdf
url http://dx.doi.org/10.1590/S1678-77572004000200002
http://hdl.handle.net/11449/211804
identifier_str_mv Journal of Applied Oral Science. Bauru, SP, Brazil: Faculdade De Odontologia De Bauru - USP, v. 12, n. 2, p. 93-98, 2004.
1678-7757
1678-7765
10.1590/S1678-77572004000200002
S1678-77572004000200002
S1678-77572004000200002.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Applied Oral Science
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 93-98
application/pdf
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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