Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes

Detalhes bibliográficos
Autor(a) principal: Damasceno, Debora Cristina [UNESP]
Data de Publicação: 2014
Outros Autores: Netto, A. O. [UNESP], Iessi, I. L. [UNESP], Gallego, F. Q. [UNESP], Corvino, S. B. [UNESP], Dallaqua, B. [UNESP], Sinzato, Y. K. [UNESP], Bueno, A. [UNESP], Calderon, Iracema de Mattos Paranhos [UNESP], Rudge, Marilza Vieira Cunha [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2014/819065
http://hdl.handle.net/11449/112239
Resumo: Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present with malformed fetuses, there is great interest in understanding the etiology, pathophysiological mechanisms, and treatment of gestational diabetes. Hyperglycemia enhances the production of reactive oxygen species, leading to oxidative stress, which is involved in diabetic teratogenesis. It has also been suggested that maternal diabetes alters embryonic gene expression, which might cause malformations. Due to ethical issues involving human studies that sometimes have invasive aspects and the multiplicity of uncontrolled variables that can alter the uterine environment during clinical studies, it is necessary to use animal models to better understand diabetic pathophysiology. This review aimed to gather information about pathophysiological mechanisms and fetal outcomes in streptozotocin-induced diabetic rats. To understand the pathophysiological mechanisms and factors involved in diabetes, the use of pancreatic regeneration studies is increasing in an attempt to understand the behavior of pancreatic beta cells. In addition, these studies suggest a new preventive concept as a treatment basis for diabetes, introducing therapeutic efforts to minimize or prevent diabetes-induced oxidative stress, DNA damage, and teratogenesis.
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spelling Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal OutcomesGlucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present with malformed fetuses, there is great interest in understanding the etiology, pathophysiological mechanisms, and treatment of gestational diabetes. Hyperglycemia enhances the production of reactive oxygen species, leading to oxidative stress, which is involved in diabetic teratogenesis. It has also been suggested that maternal diabetes alters embryonic gene expression, which might cause malformations. Due to ethical issues involving human studies that sometimes have invasive aspects and the multiplicity of uncontrolled variables that can alter the uterine environment during clinical studies, it is necessary to use animal models to better understand diabetic pathophysiology. This review aimed to gather information about pathophysiological mechanisms and fetal outcomes in streptozotocin-induced diabetic rats. To understand the pathophysiological mechanisms and factors involved in diabetes, the use of pancreatic regeneration studies is increasing in an attempt to understand the behavior of pancreatic beta cells. In addition, these studies suggest a new preventive concept as a treatment basis for diabetes, introducing therapeutic efforts to minimize or prevent diabetes-induced oxidative stress, DNA damage, and teratogenesis.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, UNESP, Grad Program Gynecol Obstet & Mastol, Lab Expt Res Gynecol & Obstet,Botucatu Med Sch, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, UNESP, Grad Program Gynecol Obstet & Mastol, Lab Expt Res Gynecol & Obstet,Botucatu Med Sch, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, BR-18618970 Botucatu, SP, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Damasceno, Debora Cristina [UNESP]Netto, A. O. [UNESP]Iessi, I. L. [UNESP]Gallego, F. Q. [UNESP]Corvino, S. B. [UNESP]Dallaqua, B. [UNESP]Sinzato, Y. K. [UNESP]Bueno, A. [UNESP]Calderon, Iracema de Mattos Paranhos [UNESP]Rudge, Marilza Vieira Cunha [UNESP]2014-12-03T13:10:33Z2014-12-03T13:10:33Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://dx.doi.org/10.1155/2014/819065Biomed Research International. New York: Hindawi Publishing Corporation, 11 p., 2014.2314-6133http://hdl.handle.net/11449/11223910.1155/2014/819065WOS:000337468100001WOS000337468100001.pdf067938762260474367586803888350780000-0002-9227-832XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioMed Research International2.5830,935info:eu-repo/semantics/openAccess2024-08-16T14:07:32Zoai:repositorio.unesp.br:11449/112239Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
title Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
spellingShingle Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
Damasceno, Debora Cristina [UNESP]
title_short Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
title_full Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
title_fullStr Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
title_full_unstemmed Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
title_sort Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
author Damasceno, Debora Cristina [UNESP]
author_facet Damasceno, Debora Cristina [UNESP]
Netto, A. O. [UNESP]
Iessi, I. L. [UNESP]
Gallego, F. Q. [UNESP]
Corvino, S. B. [UNESP]
Dallaqua, B. [UNESP]
Sinzato, Y. K. [UNESP]
Bueno, A. [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
author_role author
author2 Netto, A. O. [UNESP]
Iessi, I. L. [UNESP]
Gallego, F. Q. [UNESP]
Corvino, S. B. [UNESP]
Dallaqua, B. [UNESP]
Sinzato, Y. K. [UNESP]
Bueno, A. [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Damasceno, Debora Cristina [UNESP]
Netto, A. O. [UNESP]
Iessi, I. L. [UNESP]
Gallego, F. Q. [UNESP]
Corvino, S. B. [UNESP]
Dallaqua, B. [UNESP]
Sinzato, Y. K. [UNESP]
Bueno, A. [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
description Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present with malformed fetuses, there is great interest in understanding the etiology, pathophysiological mechanisms, and treatment of gestational diabetes. Hyperglycemia enhances the production of reactive oxygen species, leading to oxidative stress, which is involved in diabetic teratogenesis. It has also been suggested that maternal diabetes alters embryonic gene expression, which might cause malformations. Due to ethical issues involving human studies that sometimes have invasive aspects and the multiplicity of uncontrolled variables that can alter the uterine environment during clinical studies, it is necessary to use animal models to better understand diabetic pathophysiology. This review aimed to gather information about pathophysiological mechanisms and fetal outcomes in streptozotocin-induced diabetic rats. To understand the pathophysiological mechanisms and factors involved in diabetes, the use of pancreatic regeneration studies is increasing in an attempt to understand the behavior of pancreatic beta cells. In addition, these studies suggest a new preventive concept as a treatment basis for diabetes, introducing therapeutic efforts to minimize or prevent diabetes-induced oxidative stress, DNA damage, and teratogenesis.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-03T13:10:33Z
2014-12-03T13:10:33Z
2014-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2014/819065
Biomed Research International. New York: Hindawi Publishing Corporation, 11 p., 2014.
2314-6133
http://hdl.handle.net/11449/112239
10.1155/2014/819065
WOS:000337468100001
WOS000337468100001.pdf
0679387622604743
6758680388835078
0000-0002-9227-832X
url http://dx.doi.org/10.1155/2014/819065
http://hdl.handle.net/11449/112239
identifier_str_mv Biomed Research International. New York: Hindawi Publishing Corporation, 11 p., 2014.
2314-6133
10.1155/2014/819065
WOS:000337468100001
WOS000337468100001.pdf
0679387622604743
6758680388835078
0000-0002-9227-832X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BioMed Research International
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dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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instname_str Universidade Estadual Paulista (UNESP)
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reponame_str Repositório Institucional da UNESP
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