Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2014/819065 http://hdl.handle.net/11449/112239 |
Resumo: | Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present with malformed fetuses, there is great interest in understanding the etiology, pathophysiological mechanisms, and treatment of gestational diabetes. Hyperglycemia enhances the production of reactive oxygen species, leading to oxidative stress, which is involved in diabetic teratogenesis. It has also been suggested that maternal diabetes alters embryonic gene expression, which might cause malformations. Due to ethical issues involving human studies that sometimes have invasive aspects and the multiplicity of uncontrolled variables that can alter the uterine environment during clinical studies, it is necessary to use animal models to better understand diabetic pathophysiology. This review aimed to gather information about pathophysiological mechanisms and fetal outcomes in streptozotocin-induced diabetic rats. To understand the pathophysiological mechanisms and factors involved in diabetes, the use of pancreatic regeneration studies is increasing in an attempt to understand the behavior of pancreatic beta cells. In addition, these studies suggest a new preventive concept as a treatment basis for diabetes, introducing therapeutic efforts to minimize or prevent diabetes-induced oxidative stress, DNA damage, and teratogenesis. |
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Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal OutcomesGlucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present with malformed fetuses, there is great interest in understanding the etiology, pathophysiological mechanisms, and treatment of gestational diabetes. Hyperglycemia enhances the production of reactive oxygen species, leading to oxidative stress, which is involved in diabetic teratogenesis. It has also been suggested that maternal diabetes alters embryonic gene expression, which might cause malformations. Due to ethical issues involving human studies that sometimes have invasive aspects and the multiplicity of uncontrolled variables that can alter the uterine environment during clinical studies, it is necessary to use animal models to better understand diabetic pathophysiology. This review aimed to gather information about pathophysiological mechanisms and fetal outcomes in streptozotocin-induced diabetic rats. To understand the pathophysiological mechanisms and factors involved in diabetes, the use of pancreatic regeneration studies is increasing in an attempt to understand the behavior of pancreatic beta cells. In addition, these studies suggest a new preventive concept as a treatment basis for diabetes, introducing therapeutic efforts to minimize or prevent diabetes-induced oxidative stress, DNA damage, and teratogenesis.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, UNESP, Grad Program Gynecol Obstet & Mastol, Lab Expt Res Gynecol & Obstet,Botucatu Med Sch, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, UNESP, Grad Program Gynecol Obstet & Mastol, Lab Expt Res Gynecol & Obstet,Botucatu Med Sch, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, BR-18618970 Botucatu, SP, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Damasceno, Debora Cristina [UNESP]Netto, A. O. [UNESP]Iessi, I. L. [UNESP]Gallego, F. Q. [UNESP]Corvino, S. B. [UNESP]Dallaqua, B. [UNESP]Sinzato, Y. K. [UNESP]Bueno, A. [UNESP]Calderon, Iracema de Mattos Paranhos [UNESP]Rudge, Marilza Vieira Cunha [UNESP]2014-12-03T13:10:33Z2014-12-03T13:10:33Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://dx.doi.org/10.1155/2014/819065Biomed Research International. New York: Hindawi Publishing Corporation, 11 p., 2014.2314-6133http://hdl.handle.net/11449/11223910.1155/2014/819065WOS:000337468100001WOS000337468100001.pdf067938762260474367586803888350780000-0002-9227-832XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioMed Research International2.5830,935info:eu-repo/semantics/openAccess2024-08-16T14:07:32Zoai:repositorio.unesp.br:11449/112239Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes |
title |
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes |
spellingShingle |
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes Damasceno, Debora Cristina [UNESP] |
title_short |
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes |
title_full |
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes |
title_fullStr |
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes |
title_full_unstemmed |
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes |
title_sort |
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes |
author |
Damasceno, Debora Cristina [UNESP] |
author_facet |
Damasceno, Debora Cristina [UNESP] Netto, A. O. [UNESP] Iessi, I. L. [UNESP] Gallego, F. Q. [UNESP] Corvino, S. B. [UNESP] Dallaqua, B. [UNESP] Sinzato, Y. K. [UNESP] Bueno, A. [UNESP] Calderon, Iracema de Mattos Paranhos [UNESP] Rudge, Marilza Vieira Cunha [UNESP] |
author_role |
author |
author2 |
Netto, A. O. [UNESP] Iessi, I. L. [UNESP] Gallego, F. Q. [UNESP] Corvino, S. B. [UNESP] Dallaqua, B. [UNESP] Sinzato, Y. K. [UNESP] Bueno, A. [UNESP] Calderon, Iracema de Mattos Paranhos [UNESP] Rudge, Marilza Vieira Cunha [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Damasceno, Debora Cristina [UNESP] Netto, A. O. [UNESP] Iessi, I. L. [UNESP] Gallego, F. Q. [UNESP] Corvino, S. B. [UNESP] Dallaqua, B. [UNESP] Sinzato, Y. K. [UNESP] Bueno, A. [UNESP] Calderon, Iracema de Mattos Paranhos [UNESP] Rudge, Marilza Vieira Cunha [UNESP] |
description |
Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present with malformed fetuses, there is great interest in understanding the etiology, pathophysiological mechanisms, and treatment of gestational diabetes. Hyperglycemia enhances the production of reactive oxygen species, leading to oxidative stress, which is involved in diabetic teratogenesis. It has also been suggested that maternal diabetes alters embryonic gene expression, which might cause malformations. Due to ethical issues involving human studies that sometimes have invasive aspects and the multiplicity of uncontrolled variables that can alter the uterine environment during clinical studies, it is necessary to use animal models to better understand diabetic pathophysiology. This review aimed to gather information about pathophysiological mechanisms and fetal outcomes in streptozotocin-induced diabetic rats. To understand the pathophysiological mechanisms and factors involved in diabetes, the use of pancreatic regeneration studies is increasing in an attempt to understand the behavior of pancreatic beta cells. In addition, these studies suggest a new preventive concept as a treatment basis for diabetes, introducing therapeutic efforts to minimize or prevent diabetes-induced oxidative stress, DNA damage, and teratogenesis. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:10:33Z 2014-12-03T13:10:33Z 2014-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2014/819065 Biomed Research International. New York: Hindawi Publishing Corporation, 11 p., 2014. 2314-6133 http://hdl.handle.net/11449/112239 10.1155/2014/819065 WOS:000337468100001 WOS000337468100001.pdf 0679387622604743 6758680388835078 0000-0002-9227-832X |
url |
http://dx.doi.org/10.1155/2014/819065 http://hdl.handle.net/11449/112239 |
identifier_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 11 p., 2014. 2314-6133 10.1155/2014/819065 WOS:000337468100001 WOS000337468100001.pdf 0679387622604743 6758680388835078 0000-0002-9227-832X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BioMed Research International 2.583 0,935 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128170495311872 |